76872-23-6|2,4-Dichloro-6-methylthieno[2,3-d]pyrimidine| Ambeed

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of [ 76872-23-6 ] Purity: 98% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 76872-23-6 ]

CAS No. :	76872-23-6
Formula :	C₇H₄Cl₂N₂S
M.W :	219.09
SMILES Code :	CC1=CC2=C(Cl)N=C(Cl)N=C2S1
MDL No. :	MFCD15144570
InChI Key :	BTGNDWIMNVJZJY-UHFFFAOYSA-N
Pubchem ID :	11106847

Safety of [ 76872-23-6 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 76872-23-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 76872-23-6 ]

[ 76872-23-6 ] Synthesis Path-Downstream 1~33

1
[ 76872-23-6 ]
[ 76872-45-2 ]

References: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 376 - 382.

2
[ 76872-23-6 ]
[ 343856-92-8 ]

References: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 376 - 382.

3
[ 76872-71-4 ]
[ 76872-23-6 ]

Yield	Reaction Conditions	Operation in experiment
74%		b) 2, 4-dichloro-6-methylthieno[2, 3-dJpyrimidine; According to Scheme 10 Step 2: 6-methylthieno[2,3-d]pyrimidine-2,4(lH,5H)-dione (0.89Og, 0.488mmol) was added by portion into phosphorous oxychloride (5.92ml, 63.5mmol) for 20min. The mixture was stirred at r.t for 10 minutes, then pyridine (9.77mmol) was added dropwise for 5min. The mixture was then heated at 110C for 45min. The excess of phosphorous oxychloride was removed in vacuo and the residue was taken up in dichloromethane and quickly washed with cold water. The organic phase was dried over MgSO4, filtered, and evaporated till dryness, yielding crude title compound as a brown solid, (0.79Og, 74%).
21%	With N,N-dimethyl-aniline; trichlorophosphate; at 80℃; for 12h;	j00374j A mixture of compound B-50 (2.0 g, 11 mmol) and dimethylaniline (1.9 g, 16 mmol) in phosphorus oxychloride (272 mL) was stirred at 80 C for 12 hours. On completion, the mixture was concentrated, poured into water (40 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic phase was washed with brine (30 mL), dried over anhydrous sodium sulfate, filtered and concentrated in vacuum. The residue was purified by silica gel chromatography [petroleum ether: ethyl acetate = 5:11 to give compound B-51 (0.50 g, 21% yield) as a yellow solid. LCMS (J): tR=1.221 mi, (ES+) mlz (M+H)+ 241.2
	With trichlorophosphate; at 150℃; for 3h;	EXAMPLE 16 2,4-Dichloro-6-methylthieno[2,3-d]pyrimidine; 6-Methylthieno[2,3-d]pyrimidine-2,4(1 H,3H)-dione (Example 10, 2.0 g) and POCI3 were heated together in a sealed tube at 150 0C for 3 hours. The mixture was then cooled and concentrated under reduced pressure and the residue was partitioned between dichlorom ethane and aqueous saturated sodium bicarbonate. The organic layer was dried over MgSO4, filtered and concentrated. The residue was triturated with diethyl ether containing a small amount of acetonitrile and the resulting solid was collected and dried under reduced pressure to give the title compound (1.75 g). MS (ESI+) m/z219.05 (M+H)+.

With 2,3-Dimethylaniline; trichlorophosphate; at 140℃; for 12h;

Example 8b: 2,4-dichloro-6-methylthieno[2,3-d]pyrimidine; [0326] Example 8a (500mg, 2.75mmol, leq) was dissolved in Phosphorus oxychloride (200ml) containing l%v/v of Dimethylaniline in a high pressure reaction vessel. The solution was heated to 14O0C for 12 hours. Product was confirmed by LCMS. The phosphorus oxychloride was removed in vacuo and the residue co-evaporated with toluene (3x100ml) to leave 1.03g of approximately 60% pure product, which was used without further purification. [M+H] calc'd for C7H4CL2N2S, 219; found, 219.

References: [1]Patent: WO2006/30031,2006,A1 .Location in patent: Page/Page column 56.
[2]Journal of Medicinal Chemistry,1981,vol. 24,p. 376 - 382.
[3]Patent: WO2017/69980,2017,A1 .Location in patent: Paragraph 00373; 00374.
[4]Patent: WO2006/79916,2006,A1 .Location in patent: Page/Page column 81.
[5]Patent: WO2007/117995,2007,A2 .Location in patent: Page/Page column 115.

4
[ 31230-17-8 ]
[ 76872-23-6 ]
[ 952147-16-9 ]

Yield	Reaction Conditions	Operation in experiment
64%	In N,N-dimethyl-formamide; at 50℃; for 4h;	Example 8c: 2-chloro-6-methyl-N-(5-methyl-lH-pyrazol-3-yl)thieno[2,3-d]pyrimidin-4- amine; [0327] Example 8b (approx 60% pure, Ig, 2.74mmol, leq) was reacted with 5- methyl-lH-pyrazol-3 -amine (797mg, 8.22mmol, 3eq)was stirred in DMF (20ml) at 5O0C <n="117"/>for 4 hours. The reaction was complete by LCMS. Addition of water (200ml) caused the title product to appear as a tan solid, which was collected by filtration. (498mg, 64%). [M+H] calc'd for Ci6Hi5N7S, 338; found, 338.

References: [1]Patent: WO2007/117995,2007,A2 .Location in patent: Page/Page column 115-116.

5
[ 76872-23-6 ]
[ 76872-50-9 ]

References: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 376 - 382.

6
[ 76872-23-6 ]
[ 79041-56-8 ]

References: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 376 - 382.

7
[ 76872-23-6 ]
[ 79041-57-9 ]

References: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 376 - 382.

8
[ 76872-23-6 ]
[ 79041-60-4 ]

References: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 376 - 382.

9
[ 76872-23-6 ]
[ 79041-61-5 ]

References: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 376 - 382.

10
[ 76872-23-6 ]
7-Methyl-1,5-dihydro-imidazo[1,2-a]thieno[2,3-d]pyrimidin-2-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 376 - 382.

11
[ 76872-23-6 ]
6-Chloro-7-methyl-1,5-dihydro-imidazo[1,2-a]thieno[2,3-d]pyrimidin-2-one [ No CAS ]

References: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 376 - 382.

12
[ 76872-23-6 ]
[ 79603-56-8 ]

References: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 376 - 382.

13
[ 76872-23-6 ]
[ 79603-57-9 ]

References: [1]Journal of Medicinal Chemistry,1981,vol. 24,p. 376 - 382.

15
[ 2620-50-0 ]
[ 76872-23-6 ]
[ 203564-66-3 ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In dichloromethane;	EXAMPLE 1 3.02 g of 3,4-methylenedioxybenzylamine ("A") are added to a solution of 3.29 g of <strong>[76872-23-6]2,4-dichloro-6-methylthieno[2,3-d]pyrimidine</strong> in 80 ml of dichloro-methane, and, after 1.52 g of triethylamine have been added, the mixture is stirred for 12 hours at room temperature. The solvent is removed and worked up as customary. This gives 3.38 g of 2-chloro-6-methyl-4-(3,4-methylenedioxybenzylamino)thieno[2,3-d]pyrimidine, m.p. 162.
	With triethylamine; In dichloromethane;	EXAMPLE 1 3.02 g of 3,4-methylenedioxybenzylamine ("A") are added to a solution of 3.29 g of 2,4-dichloro-6-methylthieno-[2,3-d]-pyrimidine in 80 ml of methylene chloride and, after addition of 1.52 g of triethylamine, the mixture is stirred at room temperature for 12 hours. The solvent is removed and the residue is worked up in the customary manner. 3.38 g of 2-chloro-6-methyl-4-(3,4-methylenedioxybenzylamino)-thieno-[2,3-d]-pyrimidine are obtained, m.p. 162.
	With triethylamine; In dichloromethane;	EXAMPLE 1 2-Chloro-6-Methyl-4-(3,4-Methylenedioxybenzylamino)-Thieno-[2,3-d]-Pyrimidine A solution of 2,4-dichloro-6-methyl-thieno-[2,3-d]-pyrimidine (3.29 g) in dichloromethane (30 ml) is charged with 3,4-methylenedioxybenzylamine ("A") (3.02 g). Triethylamine (1.52 g) is added, and the mixture is stirred at room temperature. The solvent is removed, and the usual workup yields 2-chloro-6-methyl-4-(3,4-methylenedioxybenzylamino)-thieno-[2,3-d]-pyrimidine (3.38 g) Mp. 162 C.

References: [1]Patent: WO2005/47292,2005,A1 .Location in patent: Page/Page column 59.
[2]Patent: US6110920,2000,A .
[3]Patent: US6130223,2000,A .
[4]Patent: US6133271,2000,A .

16
[ 76872-23-6 ]
[ 5188-07-8 ]
2-chloro-6-methyl-4-(methylthio)thieno[2,3-d]pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In tetrahydrofuran; water; for 4h;Heating / reflux;	To a THE (50 mL) solution of <strong>[76872-23-6]2,4-dichloro-6-methylthieno[2,3-d]pyrimidine</strong> (3.80 g, 17.3 mmol) was added a 15% aqueous sodium methyl mercaptan solution (9.71 g, 20.8 mmol), followed by heating under reflux for 4 hours. After completion of the reaction, the precipitated salt was filtrated off and the filtrate was poured into water and extracted with ethyl acetate. The resulting extract solution was washed with water and brine and then the solvent was removed by evaporation. A part of the product was purified on a silica gel column (Kiesel gel 60 manufactured by MERCK, 20% AcOEt-Hex) to obtain 2-chloro-6-methyl-4-(methylthio)thieno[2,3-d]pyrimidine. The remainder was used in the next reaction without purification. 1H-NMR (400MHz, CDCl3): 2.60(d, 3H, J=1.2Hz), 2.70(s, 3H), 6.94(q, 1H, J=1.2Hz). mp: 111-112C

References: [1]Patent: EP1544202,2005,A1 .Location in patent: Page/Page column 55.

17
2,4-dihydroxy-6-methylthieno[2,3-d]pyrimidine [ No CAS ]
[ 76872-23-6 ]

Yield	Reaction Conditions	Operation in experiment
79%	With trichlorophosphate; In DMF (N,N-dimethyl-formamide); at 100℃; for 2.5h;Heating / reflux;	Phosphorus oxychloride (28.1 g, 0.184 mol) was added to a DMF (10 mL) solution of 2,4-dihydroxy-6-methylthieno[2,3-d]pyrimidine (6.70 g, 36.8 mmol), followed by heating under reflux at 100C for 2.5 hours. After completion of the reaction, the reaction liquid was poured into ice-water and precipitated crystals were collected by filtration. After the resulting crystals were dissolved in ethyl acetate, the solution was washed with water and brine and then the solvent was removed by evaporation to obtain 2,4-dichloro-6-methylthieno[2,3-d]pyrimidine (6.40 g, 79%). 1H-NMR (400MHz, CDCl3): 2.65(d, 3H, J=1.2Hz), 7.07(q, 1H, J=1.2Hz). mp: 145-146C

References: [1]Patent: EP1544202,2005,A1 .Location in patent: Page/Page column 54-55.

18
[ 76872-23-6 ]
biphenyl-4-yl(piperazin-1-yl)methanone [ No CAS ]
[ 902766-03-4 ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20℃;	EXAMPLE 44 4-[4-(1 ,1 '-Biphenyl-4-ylcarbonyl)piperazin-1 -yl]-2-chloro-6-methylthieno[2,3-d]pyrimidine; 2,4-Dichloro-6-methylthieno[2,3-d]pyrimidine (Example 16, 0.80 g) was dissolved in a mixture of THF/DMF (10 mL/6 mL) followed by addition of 1-(1 ,1'-biphenyl-4-ylcarbonyl)piperazine (1.45 g, 3.65 mmol) and diisopropylethylamine (0.61 g, 4.7 mmol). The mixture was stirred at room temperature overnight. The mixture was partitioned between ethyl acetate and brine. The organic layer was separated and washed additional four times with brine. The organic layer was dried over MgSO4, filtered and concentrated. The resulting residue was stirred in hot acetonitrile with a few drops of methanol. The resulting solid was collected and dried under reduced pressure to give 1.41 g of the title compound. MS (ESI+) for C24H21CIN4OS1 m/z 449.242 (M+H)+. 1H NMR (400 MHz, CDCI3) δ 7.66 to 7.36 (m, 9H), 6.93 (s, 1H), 3.95 (br s, 8H), 2.54 (s, 3H).

References: [1]Patent: WO2006/79916,2006,A1 .Location in patent: Page/Page column 94.

19
[ 76872-23-6 ]
[ 140-75-0 ]
2-chloro-6-methyl-4-(4-fluorobenzylamino)-thieno-[2,3-d]-pyrimidine [ No CAS ]
2-chloro-5-methyl-4-(4-fluorobenzylamino)-thieno-[2,3-d]-pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 45 Following the procedure of Example 1, the reaction of 4-fluorobenzylamine with 2,4-dichloro-6-methyl-thieno-[2,3-d]-pyrimidine yields 2-chloro-6-methyl-4-(4-fluorobenzylamino)-thieno-[2,3-d]-pyrimidine with 2,4-dichloro-5-methyl-thieno-[2,3-d]-pyrimidine yields 2-chloro-5-methyl-4-(4-fluorobenzylamino)-thieno-[2,3-d]-pyrimidine.

References: [1]Patent: US6133271,2000,A .

20
[ 76872-23-6 ]
[ 100-46-9 ]
2-chloro-6-methyl-4-benzylamino-thieno-[2,3-d]-pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 34 Following the procedure of Example 1, the reaction of benzylamine with 2,4-dichloro-6-methyl-thieno-[2,3-d]-pyrimidine yields 2-chloro-6-methyl-4-benzylamino-thieno-[2,3-d]-pyrimidine.

References: [1]Patent: US6133271,2000,A .

21
[ 115514-77-7 ]
[ 76872-23-6 ]
2-chloro-6-methyl-4-(3-chloro-4-methoxybenzylamino)-thieno-[2,3-d]-pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 12 Following the procedure of Example 1, the reaction of 3-chloro-4-methoxybenzylamine with 2,4-dichloro-6-methyl-thieno-[2,3-d]-pyrimidine yields 2-chloro-6-methyl-4-(3-chloro-4-methoxybenzylamino)-thieno-[2,3-d]-pyrimidine.
		EXAMPLE 12 Following the procedure of Example 1, the reaction of 3-chloro-4-methoxybenzylamine with 2,4-dichloro-6-methyl-thieno-[2,3-d]-pyrimidine yields 2-chloro-6-methyl-4-(3-chloro-4-methoxybenzylamino)-thieno-[2,3-d]-pyrimidine

References: [1]Patent: US5948911,1999,A .
[2]Patent: US6133271,2000,A .

22
[ 7409-18-9 ]
[ 76872-23-6 ]
2-chloro-6-methyl-4-(3-nitrobenzylamino)-thieno-[2,3-d]-pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 66 Following the procedure of Example 1, the reaction of 3-nitrobenzylamine with 2,4-dichloro-6-methyl-thieno-[2,3-d]-pyrimidine yields 2-chloro-6-methyl-4-(3-nitrobenzylamino)-thieno-[2,3-d]-pyrimidine.
		EXAMPLE 66 Following the procedure of Example 1, the reaction of 3-nitrobenzylamine with 2,4-dichloro-6-methyl-thieno-[2,3-d]-pyrimidine yields 2-chloro-6-methyl-4-(3-nitrobenzylamino)-thieno-[2,3-d]-pyrimidine

References: [1]Patent: US5948911,1999,A .
[2]Patent: US6133271,2000,A .

23
[ 76872-23-6 ]
[ 5763-61-1 ]
2-chloro-6-methyl-4-(3,4-dimethoxybenzylamino)-thieno-[2,3-d]-pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 23 Following the procedure of Example 1, the reaction of 3,4-dimethoxybenzylamine with 2,4-dichloro-6-methyl-thieno-[2,3-d]-pyrimidine yields 2-chloro-6-methyl-4-(3,4-dimethoxybenzylamino)-thieno-[2,3-d]-pyrimidine.

References: [1]Patent: US6133271,2000,A .

24
[ 76872-23-6 ]
[ 102-49-8 ]
2-chloro-6-methyl-4-(3,4-dichlorobenzylamino)-thieno-[2,3-d]-pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 55 Following the procedure of Example 1, the reaction of 3,4-dichlorobenzylamine with 2,4-dichloro-6-methyl-thieno-[2,3-d]-pyrimidine yields 2-chloro-6-methyl-4-(3,4-dichlorobenzylamino)-thieno-[2,3-d]-pyrimidine.

References: [1]Patent: US6133271,2000,A .

25
[ 1484-85-1 ]
[ 76872-23-6 ]
2-chloro-6-methyl-4-(3-nitrobenzylamino)-thieno-[2,3-d]-pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 77 Following the procedure of Example 1, the reaction of 3,4-methylenedioxyphenethylamine with 2,4-dichloro-6-methyl-thieno-[2,3-d]-pyrimidine yields 2-chloro-6-methyl-4-(3-nitrobenzylamino)-thieno-[2,3-d]-pyrimidine.
		EXAMPLE 77 Following the procedure of Example 1, the reaction of 3,4-methylenedioxyphenethylamine with 2,4-dichloro-6-methyl-thieno-[2,3-d]-pyrimidine yields 2-chloro-6-methyl-4-(3-nitrobenzylamino)-thieno-[2,3-d]-pyrimidine

References: [1]Patent: US5948911,1999,A .
[2]Patent: US6133271,2000,A .

26
[ 76872-23-6 ]
[ 64-04-0 ]
2-chloro-6-methyl-N-phenethylthieno[2,3-d]pyrimidin-4-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92.7%	With potassium carbonate; In acetonitrile; at 80℃; for 17h;	c) 2-chloro-6-methyl-N-phenethylthieno[2,3-d]pyrimidin-4-amine; According to Scheme 10 Step 3: A suspension of 2,4-dichloro-6-methylthieno[2,3-d] pyrimidine (0.70Og, 3.20mmol), phenethylamine (0.481ml, 3.83mmol) and potassium carbonate (0.662g, 4.79mmol) in acetonitrile (6ml) was heated at 80C to 17 hours. Then, a little of water was added to the mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over MgSO4, filtered, and evaporated till dryness. The residue (brown solid, 1.0Og) was purified by chromatography over silica gel (Flashmart Pack: 50g/60-40um, eluent DCM) yielding title compound (0.90Og, 92.7%) as a yellow solid..

References: [1]Patent: WO2006/30031,2006,A1 .Location in patent: Page/Page column 56-57; 66.

27
[ 76872-23-6 ]
[ 87478-90-8 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2079 - 2085.

28
[ 76872-23-6 ]
[ 1607479-53-7 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2079 - 2085.

29
[ 76872-23-6 ]
[ 1607479-54-8 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2079 - 2085.

30
[ 138564-58-6 ]
[ 503-38-8 ]
[ 76872-23-6 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,p. 2079 - 2085.

31
[ 19369-53-0 ]
[ 76872-23-6 ]

References: [1]Patent: WO2017/69980,2017,A1 .

32
[ 76872-23-6 ]
2-chloro-6-methylthieno[2,3-d]pyrimidine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
42%	With ammonium hydroxide; zinc; In ethanol; at 80℃; for 3h;	j00376j A mixture of compound B-51 (0.45 g, 2.1 mmol), zinc (1.1 g, 16 mmol) and aqueous ammonia (0.40 mL, 10 mmol, 27%) in ethanol (5.0 mL) was stirred at 80 C for 3 hours. On completion, the mixture was filtered, concentrated in vacuo, dissolved in water (40 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic phase was washed with brine (30 mL), dried with anhydrous sodium sulfate, filtered and concentrated in vacuum. The residue was purified by silica gel chromatography [petroleum ether: ethyl acetate = 10:11 to give compound B-52 (0.16 g, 42% yield) as a yellow solid. ‘H-NMR (CDC13, 400 MHz): 8.82 (s, 1H), 6.98 (d, J1.2 Hz, 1H), 2.64 (s, 3H).

References: [1]Patent: WO2017/69980,2017,A1 .Location in patent: Paragraph 00375; 00376.

33
[ 76872-23-6 ]
(R)-N-(6-methylthieno[2,3-d]pyrimidin-2-yl)-4H-1‘-azaspiro[isoxazole-5,3'-bicyclo[2.2.2]octan]-3-amine hydrochloride [ No CAS ]

References: [1]Patent: WO2017/69980,2017,A1 .

Historical Records

Technical Information

• Alkyl Halide Occurrence • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling

Related Functional Groups of
[ 76872-23-6 ]

Chlorides

A888113 [87478-74-8]

2,4-Dichloro-6-ethylthieno[2,3-d]pyrimidine

Similarity: 0.93

A965847 [106691-21-8]

4-Chloro-6-methylthieno[2,3-d]pyrimidine

Similarity: 0.93

A773408 [902765-62-2]

2,4-Dichloro-6-propylthieno[2,3-d]pyrimidine

Similarity: 0.90

A211601 [902765-47-3]

2,4-Dichloro-6-phenylthieno[2,3-d]pyrimidine

Similarity: 0.90

A597349 [81136-42-7]

4-Chloro-6-ethylthieno[2,3-d]pyrimidine

Similarity: 0.88

Related Parent Nucleus of
[ 76872-23-6 ]

Other Aromatic Heterocycles

A888113 [87478-74-8]

2,4-Dichloro-6-ethylthieno[2,3-d]pyrimidine

Similarity: 0.93

A965847 [106691-21-8]

4-Chloro-6-methylthieno[2,3-d]pyrimidine

Similarity: 0.93

A773408 [902765-62-2]

2,4-Dichloro-6-propylthieno[2,3-d]pyrimidine

Similarity: 0.90

A211601 [902765-47-3]

2,4-Dichloro-6-phenylthieno[2,3-d]pyrimidine

Similarity: 0.90

A597349 [81136-42-7]

4-Chloro-6-ethylthieno[2,3-d]pyrimidine

Similarity: 0.88

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

{[proInfo.proName]}

CAS No.: 76872-23-6

{[proInfo.proName]}