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Chemical Structure| 768-94-5 Chemical Structure| 768-94-5

Structure of Amantadine
CAS No.: 768-94-5

Chemical Structure| 768-94-5

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Synonyms: 1-Aminoadamantane; 1-Adamantanamine; 1-Adamantylamine

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Product Citations

Product Citations

Choi, So Ra ; Wang, Hee Myeong ; Shin, Min Hyeon ; Lim, Hyun-Suk ;

Abstract: Steroid receptor coactivator-1 (SRC-1) is a transcription coactivator playing a pivotal role in mediating a wide range of signaling pathways by interacting with related transcription factors and nuclear receptors. Aberrantly elevated SRC-1 activity is associated with cancer metastasis and progression, and therefore, suppression of SRC-1 is emerging as a promising therapeutic strategy. In this study, we developed a novel SRC-1 degrader for targeted degradation of cellular SRC-1. This mol. consists of a selective ligand for SRC-1 and a bulky hydrophobic group. Since the hydrophobic moiety on the protein surface could mimic a partially denatured hydrophobic region of a protein, SRC-1 could be recognized as an unfolded protein and experience the chaperone-mediated degradation in the cells through the ubiquitin-proteasome system (UPS). Our results demonstrate that a hydrophobic-tagged chimeric mol. is shown to significantly reduce cellular levels of SRC-1 and suppress cancer cell migration and invasion. Together, these results highlight that our SRC-1 degrader represents a novel class of therapeutic candidates for targeting cancer metastasis. Moreover, we believe that the hydrophobic tagging strategy would be widely applicable to develop peptide-based protein degraders with enhanced cellular activity.

Keywords: PROTACs ; SRC-1 transcriptional coactivator ; cancer metastasis ; hydrophobic tagging ; proteasomal degradation ; ubiquitination ; ubiquitin–proteasome system

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Product Details of [ Amantadine ]

CAS No. :768-94-5
Formula : C10H17N
M.W : 151.25
SMILES Code : NC12CC3CC(C2)CC(C3)C1
Synonyms :
1-Aminoadamantane; 1-Adamantanamine; 1-Adamantylamine
MDL No. :MFCD00074732

Safety of [ Amantadine ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Description
Amantadine, known chemically as 1-Adamantanamine, is a potent orally active antiviral agent effective against influenza A viruses. It also blocks various ion channels, including NMDA and M2, and inhibits Coronavirus ion channels, showcasing its broad antiviral capabilities. Additionally, Amantadine possesses anti-orthopoxvirus and anticancer activities, making it applicable in Parkinson's disease, postoperative cognitive dysfunction (POCD), and COVID-19 research[1].[2].[3].[4].[5].[6].
 

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