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Chemical Structure| 768-31-0 Chemical Structure| 768-31-0

Structure of 768-31-0

Chemical Structure| 768-31-0

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Product Details of [ 768-31-0 ]

CAS No. :768-31-0
Formula : C6H10F3N
M.W : 153.15
SMILES Code : FC(C1CNCCC1)(F)F
MDL No. :MFCD02183561

Safety of [ 768-31-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 768-31-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 768-31-0 ]

[ 768-31-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 768-31-0 ]
  • [ 1227934-69-1 ]
  • [ 1227934-71-5 ]
  • [ 1227934-91-9 ]
YieldReaction ConditionsOperation in experiment
2-(3-(trifluoromethyl)piperidin-1-yl)-4-trifluoromethyloxazole-5-carboxylic Acid (A-24) Intermediate A-24 was prepared by the general procedure for intermediate A-4, by using A-2 and 3-(trifluoromethyl)piperidine as starting materials. MS (M+1): 333.
  • 2
  • [ 768-31-0 ]
  • [ 161957-56-8 ]
  • (3-bromo-2-fluoro-phenyl)-(3-trifluoromethyl-piperidin-1-yl)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 4h; 18a) (3-Bromo-2-fluoro-phenyl)-(3-trifluoromethyl-piperidin-1 -yl)-methanone A solution of 3-bromo-2-fluoro-benzoic acid (0.500 g, 2.28 mmol), HATU (0.868 g, 2.28 mmol), 3-trifluoromethylpiperidine (0.402 g, 2.63 mmol) and DIPEA (0.885 g, 6.85 mmol) in DCM (10 ml_) was stirred for 4 h. The mixture was diluted with DCM and the organic phase washed with aqueous NaHC03 and dried by passage through a phase separation cartridge. Concentration to dryness gave the crude product (1 .89g, quantative), used without further purification. LC-MS m/z 354 (M + H) +, 1 .41 (ret. time).
 

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