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Chemical Structure| 765912-47-8 Chemical Structure| 765912-47-8

Structure of 765912-47-8

Chemical Structure| 765912-47-8

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Product Details of [ 765912-47-8 ]

CAS No. :765912-47-8
Formula : C9H8N2O
M.W : 160.17
SMILES Code : NC1=CC=C(C2=NOC=C2)C=C1
MDL No. :MFCD18824909

Safety of [ 765912-47-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 765912-47-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 765912-47-8 ]

[ 765912-47-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 765912-47-8 ]
  • [ 13395-36-3 ]
  • [ 2043-61-0 ]
  • [ 1067181-45-6 ]
YieldReaction ConditionsOperation in experiment
30% With acetic acid; at 95℃; for 5h; Example 1 Preparation of 5-cyclohexyl-4-(2,2-dimethylpropionoyl)-3-hydroxy-1-(4-isoxazol-3-ylphenyl)-1,5-dihydropyrrol-2-one (I-32) To a mixture of ethyl (trimethylaceto)pyruvate (1.00 g, 5 mmol) and 4-isoxazol-3-yl-aniline (0.80 g, 5 mmol) in acetic acid (4 mL) was added cyclohexane carboaldehyde (0.61 mL, 5 mmol). The mixture was stirred at 95C for 5 hr, and cooled to r.t.. The precipitate was collected by filtration, washed with ethyl acetate and dried to give 5-cyclohexyl-4-(2,2-dimethylpropionoyl)-3-hydroxy-1-(4-isoxazol-3-ylphenyl)-1,5-dihydropyrrol-2-one (0.60 g, 30%) as pale yellow crystals. mp: 259-260C, 1H-NMR (delta ppm TMS/DMSO-d6) 0.62-1.78 (11H, m), 1.27 (9H, s), 5.28 (1H, d, J = 2.4 Hz), 7.20 (1H, d, J = 1.8 Hz), 7.75 (2H, d, J = 8.7 Hz), 7.98 (2H, d, J = 8.7 Hz), 9.03 (1H, d, J = 1.8 Hz), 11.84 (1H, s).
 

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