76243-24-8| 1-(Benzyloxy)-2-fluoro-4-nitrobenzene| Ambeed

Yield	Reaction Conditions	Operation in experiment
100%	With ammonium formate; iron; In water; toluene;Heating / reflux;	A mixture of iron powder (45.2 g, 0.809 g atoms), ammonium formate (53.6 g, 0.850 mol), l-benzyloxy-2-fluoro-4-nitrobenzene (50.0 g, 0.200 mol), toluene (400 mL) and water (400 mL) was heated to reflux overnight. The mixture was filtered through Celite and washed with hot ethyl acetate. The combined organic layers were washed with water and brine, then dried over sodium sulfate and concentrated to afford 4-benzyloxy-3-fluoroaniline (44 g, 100 %). 1H NMR (400 MHz, J6-DMSO): delta 7.43-7.26 (m, 5H), 6.90 (dd, IH), 6.49 (dd, IH), 6.34 (m, IH), 4.99 (br s, 2H), 4.98 (s, 2H); 13C NMR (100 MHz, J6-DMSO): delta 171.1, 155.1, 152.7, 144.9, 138.0, 137.2, 129.6, 129.0, 128.5, 118.9, 110.0, 102.9, 72.5; IR (cm"1): 1510, 1454, 1277, 1215, 1126, 1007, 957, 843, 800, 789, 739, 694, 604; LC/MS (M+H = 218).
100%	With ammonium formate; iron; In water; toluene;Heating / reflux;	A mixture of iron powder (45.2 g, 0. 809 g atoms), ammonium formate (53.6 g, 0. 850 mol), 1-benzyloxy-2-fluoro-4-nitrobenzene (50.0 g, 0.200 mol), toluene (400 mL) and water (400 ML) was heated to reflux overnight. The mixture was filtered through Celite and washed with hot ethyl acetate. The combined organic layers were washed with water and brine, then dried over sodium sulfate and concentrated to afford 4-benzyloxy-3-fluoroaniline (44 g, 100 %).
99.9%	With iron(III) chloride hexahydrate; pyrographite; hydrazine hydrate; In ethanol; at 80℃; for 2h;	The compound of formula (2) (154 g, 0.624 mol), ferric chloride hexahydrate (3.24 g, 0.012 mol) and15.4 g of activated carbon was added to 1.23 L of ethanol, heated at 80 C., and 80% hydrazine hydrate (156 g, 3.12 mol) was added dropwise.Drops, reaction 2h. After hot filtration, the filtrate was evaporated to dryness under reduced pressure to give 135 g of a dark yellow oil.That is, the compound (4) 4-benzyloxy-3-fluoroaniline, a yield of 99.9%;

94%	With iron; ammonium chloride; In ethanol; water; at 90℃; for 2h;	compound 1 (72.80 g, 294.74 mmol, 1 eq), reduced iron powder (99.00 g,1768.42 mmol, 6 eq) and ammonium chloride (94.59 g, 1768.42 mmol, 6 eq) were mixed with EtOH:H2O(2:1), and refluxed at 90C for 2 h. After cooling to room temperature, the mixture was filtered. Thefiltered and concentrated to give the brown oily substance compound 2 (60.00 g, 94%). 1H-NMR(400 MHz, CDCl3) delta 7.42 (d, J = 7.2 Hz, 2H), 7.36 (t, J = 7.2 Hz, 2H), 7.31 (t, J = 7.0 Hz, 1H), 6.80 (t,J = 9.0 Hz, 1H), 6.46 (dd, J = 12.4, 2.8 Hz, 1H), 6.33 (d, J = 8.8 Hz, 1H), 5.03 (s, 2H). ESI-MS (m/z): 217.9[M + H]+
83.17%	With ammonium formate; iron; In ethanol; water;Reflux;	4-Benzyloxy-3-fluoroaniline.A mixture of iron powder (1.07g, 16.96mmol), ammonium formate (1.07g, 16.96mmol),1-benzyloxy-2-fluoro-4-nitrobenzene (1g, 4.04mmol), ethanol (400 mL) and water(100 mL) was heated to reflux overnight. The mixture was filtered throughCelite and washed with hot ethyl acetate. The combined organic layers werewashed with water and brine, then dried over sodium sulfate and concentrated toafford 4-benzyloxy-3-fluoroaniline (0.73g,83.17 %).
83.17%	With water; ammonium formate; iron; In toluene; for 8h;Reflux;	A mixture of iron powder (1.07 g, 16.96 mmol), ammonium formate (1.07 g, 16.96 mmol), 1-benzyloxy-2-fluoro-4-nitrobenzene (1 g, 4.04 mmol), methylbenzene (30 mL) and water (30 mL) was heated to reflux overnight. The mixture was filtered through celite and washed with hot ethyl acetate. The combined organic layers were washed with water and brine, then dried over anhydrous Na2SO4 and concentrated to afford 4-benzyloxy-3-fluoroaniline (0.73 g, 83.17 %). 1H-NMR (300MHz, CDCl3) delta: 7.43-7.27 (m, 5H), 6.82-6.77 (t, J = 8.82 Hz, 1H), 6.48-6.43 (dd, J = 2.61, 12.58 Hz, 1H), 6.33-6.30 (m, 1H), 5.02 (s, 2H), 3.50 (s, Ar-NH2, 2H).
	With hydrazine;Raney nickel; In methanol; at 20℃; for 2h;	2.91 ml of hydrazine monohydrate and about 1 g of developed Raney nickel catalyst were added to a methanol (60 ml) solution of 4.94 g of 4-benzyloxy-3-fluoronitrobenzene, and the reaction liquid was stirred at room temperature for 2 hours. The catalyst was removed through filtration through Celite, and the solvent was evaporated away under reduced pressure to obtain the entitled compound as a yellow oily substance.

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Product Details of [ 76243-24-8 ]

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[ 76243-24-8 ] Synthesis Path-Downstream 1~1

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed