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Chemical Structure| 76207-22-2 Chemical Structure| 76207-22-2

Structure of 76207-22-2

Chemical Structure| 76207-22-2

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Product Details of [ 76207-22-2 ]

CAS No. :76207-22-2
Formula : C7H13Br
M.W : 177.08
SMILES Code : CC1(C)CC(CBr)C1
MDL No. :MFCD17170399
InChI Key :LXYGBCXUPQXFKM-UHFFFAOYSA-N
Pubchem ID :12656857

Safety of [ 76207-22-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 76207-22-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 76207-22-2 ]

[ 76207-22-2 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 76207-24-4 ]
  • [ 76207-22-2 ]
  • 2
  • [ 76207-22-2 ]
  • [ 762-62-9 ]
  • [ 75017-20-8 ]
  • [ 76207-19-7 ]
  • [ 76207-23-3 ]
  • 3
  • [ 76207-22-2 ]
  • [ 762-62-9 ]
  • [ 75017-20-8 ]
  • [ 76207-23-3 ]
  • 4
  • [ 76207-22-2 ]
  • [ 76207-19-7 ]
  • 5
  • [ 34970-18-8 ]
  • [ 76207-22-2 ]
  • 6
  • [ 75017-17-3 ]
  • [ 76207-22-2 ]
  • 7
  • N-(1-methylcyclopropyl)-3-[(3-methylisoxazol-5-yl)methyl]-2,4-dioxo-1H-quinazoline-6-sulfonamide [ No CAS ]
  • [ 76207-22-2 ]
  • 1-[(3,3-dimethylcyclobutyl)methyl]-N-(1-methylcyclopropyl)-3-[(3-methylisoxazol-5-yl)methyl]-2,4-dioxoquinazoline-6-sulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
4% With caesium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 120.0℃; for 1.0h;Microwave irradiation; Λ/-(1 -Methylcyclopropyl)-3-((3-methylisoxazol-5-yl)methyl)-2,4-dioxo-1 ,2,3,4- tetrahydroquinazoline-6-sulfonamide (100 mg, 0.260 mmol), cesium carbonate (100 mg, 0.3100 mmol), sodium iodide (8 mg, 0.05 mmol) and 1 -bromo-2,2-dimethylpropane (426 mg, 2.8 mmol) in DMF (2 mL) was heated by microwave irradiation to 130 C for 1 .5 h. The reaction mixture was diluted with water (10 mL) and extracted with EtOAc (2 x 20 mL). The organic phase was combined, washed with brine (10 mL), passed through a hydrophobic frit and evaporated to dryness. The crude product mixture was purified by prep HPLC (high pH) to give the desired product (14 mg, 0.03 mmol, 12%) as an off-white powder.This compound was prepared according to Example 465 using Λ/-(1 - methylcyclopropyl)-3-((3-methylisoxazol-5-yl)methyl)-2,4-dioxo-1 ,2,3,4- tetrahydroquinazoline-6-sulfonamide (100 mg, 0.260 mmol) and 3-(bromomethyl)-1 ,1 - dimethylcyclobutane (50 mg, 0.280 mmol). The reaction mixture was heated by microwave irradiation to 120 C for 1 h. This afforded the desired product (5 mg, 0.01 mmol, 4%) as a white powder.
 

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