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Chemical Structure| 75970-64-8 Chemical Structure| 75970-64-8

Structure of 75970-64-8

Chemical Structure| 75970-64-8

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Product Details of [ 75970-64-8 ]

CAS No. :75970-64-8
Formula : C19H23Br2FN4
M.W : 486.22
SMILES Code : FC1=CC=C(CN2C3=CC=CC=C3N=C2NC4CCNCC4)C=C1.[H]Br.[H]Br

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Application In Synthesis of [ 75970-64-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 75970-64-8 ]

[ 75970-64-8 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 50606-58-1 ]
  • [ 75970-64-8 ]
  • 1-[(4-fluorophenyl)methyl]-N-[1'-(phenylmethyl)-[1,3'-bipiperidin]-4-yl]-1H-benzimidazol-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium acetate;palldium-on-charcoal; In thiophene; ethanol; 2-methoxy-ethanol; water; A mixture of 25 parts of <strong>[50606-58-1]1-(phenylmethyl)-3-piperidinone hydrochloride</strong>, 55 parts of 1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amine dihydrobromide, 1 parts of a solution of thiophene in ethanol 4%, 50 parts of potassium acetate and 500 parts of 2-methoxyethanol was hydrogenated at normal pressure and at 50 C. with 5 parts of palldium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was taken up in water and the whole was alkalized with sodium hydroxide. The product was extracted with dichloromethane. The extract was dried, filtered and evaporated. The residue was crystallized twice from acetonitrile. The product was filtered off and dried, yielding 9.75 parts of 1-[(4-fluorophenyl)methyl]-N-[1'-(phenylmethyl)-[1,3'-bipiperidin]-4-yl]-1H-benzimidazol-2-amine; mp. 174.6 C. (intermediate 70).
 

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