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Chemical Structure| 75959-08-9 Chemical Structure| 75959-08-9

Structure of 75959-08-9

Chemical Structure| 75959-08-9

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Product Details of [ 75959-08-9 ]

CAS No. :75959-08-9
Formula : C10H10N2O
M.W : 174.20
SMILES Code : NC1=CC(OC)=C2N=CC=CC2=C1
MDL No. :MFCD02684223
InChI Key :FOOUDKKEHNADTE-UHFFFAOYSA-N
Pubchem ID :13213288

Safety of [ 75959-08-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 75959-08-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 75959-08-9 ]

[ 75959-08-9 ] Synthesis Path-Downstream   1~23

  • 1
  • [ 580-15-4 ]
  • [ 75959-08-9 ]
  • 2-[6]quinolyl-5-methoxy-2<i>H</i>-[1,2,3]triazolo[4,5-<i>f</i>]quinoline [ No CAS ]
  • 2
  • [ 75-44-5 ]
  • [ 75959-08-9 ]
  • 8,8'-dimethoxy-1,1'-dimethyl-6,6'-ureylene-bis-quinolinium; bis-methyl sulfate [ No CAS ]
  • 3
  • [ 75959-08-9 ]
  • [ 759396-95-7 ]
  • <i>N</i>2-(2-diethylamino-ethyl)-<i>N</i>4-(8-methoxy-[6]quinolyl)-6-methyl-pyrimidine-2,4-diyldiamine [ No CAS ]
  • 4
  • [ 75959-08-9 ]
  • [ 127-68-4 ]
  • [ 951-06-4 ]
  • 5
  • [ 75959-08-9 ]
  • [ 78-94-4 ]
  • [ 100872-11-5 ]
  • 6
  • [ 75959-08-9 ]
  • [ 110-13-4 ]
  • 6-(2,5-dimethyl-pyrrol-1-yl)-8-methoxy-quinoline [ No CAS ]
  • 7
  • [ 75959-08-9 ]
  • [ 2049-86-7 ]
  • 1-(8-methoxy-[6]quinolyl)-2,5-dimethyl-pyrrole-3,4-dicarboxylic acid diethyl ester [ No CAS ]
  • 9
  • [ 75959-08-9 ]
  • [ 123-63-7 ]
  • 6-methoxy-3-methyl-[4,7]phenanthroline [ No CAS ]
  • 11
  • [ 865-33-8 ]
  • [ 88609-18-1 ]
  • [ 75959-08-9 ]
  • [ 88609-45-4 ]
  • 12
  • [ 865-47-4 ]
  • [ 88609-18-1 ]
  • [ 75959-08-9 ]
  • [ 104369-78-0 ]
  • [ 104392-90-7 ]
  • 13
  • [ 88609-18-1 ]
  • [ 75959-08-9 ]
  • [ 88609-45-4 ]
  • 15
  • [ 75959-08-9 ]
  • (+-)-diethyl-<4-chloro-pentyl>-amine hydrobromide [ No CAS ]
  • <i>N</i>4,<i>N</i>4-diethyl-<i>N</i>1-(8-methoxy-[6]quinolyl)-1-methyl-butanediyldiamine [ No CAS ]
  • 17
  • [ 75959-08-9 ]
  • [ 947-74-0 ]
  • 18
  • [ 75959-08-9 ]
  • 5-ethoxy-[4,7]phenanthroline [ No CAS ]
  • 19
  • [ 75959-08-9 ]
  • [ 99420-18-5 ]
  • 20
  • [ 75959-08-9 ]
  • [ 1071-98-3 ]
  • [ 75959-16-9 ]
YieldReaction ConditionsOperation in experiment
In ethanol; The starting material may be obtained, for example, as follows: 16.2 g of <strong>[75959-08-9]6-amino-8-methoxyquinoline</strong> are dissolved in 300 ml of ethanol, 8 g of acetylenedicarboxylic acid dinitrile are added and the solution is stirred for 2 hours at room temperature. The solution is then evaporated to dryness under reduced pressure and recrystallized from ethanol. The 1-imino-6-methoxy-1,4-dihydro-4,7-phenanthroline-3-carboxylic acid nitrile is obtained which can be used further without further purification.
  • 21
  • [ 75959-08-9 ]
  • [ 1018906-20-1 ]
  • [ 1080641-89-9 ]
YieldReaction ConditionsOperation in experiment
88.8% With sodium t-butanolate; CyJohnPhos;palladium diacetate; In diethylene glycol dimethyl ether; for 2.5h;Reflux; 1. In a 250ml three-mouth flask, 6-amino-8-methoxylquinoline (5.0g), 2-choro-N-cyclopropyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-6-amine (9.3g), catalyst Pd(OAc)2(0.25g), ligand 7 (0.25g), sodium tert-butoxide (4.5g) and ethylene glycol dimethyl ether (100ml) are added in turn. The above mixture is stirred and heated to reflux, and the above mixture is reacted under refluxing for 2.5h. The completion of reaction is checked with TCL analysis. The reaction mixture is cooled to room temperature. After filteration, a filter cake is completely washed with ethylene glycol dimethyl ether for 2 times, and a filtrate is concentrated to dry and the reisdue is purified by column chromatography on silica gel to obtain a conjugate (11.0g). The yield is about 88.8% on the basis of aminoquinoline
~ 88.8% With sodium t-butanolate; CyJohnPhos;palladium diacetate; In 1,2-dimethoxyethane; for 2.5h;Reflux; In a 250 ml three-mouth flask, 6-amino-8-methoxylquinoline (5.0 g), 2-choro-N-cyclopropyl-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-6-amine (9.3 g), catalyst Pd(OAc)2 (0.25 g), ligand 7 (0.25 g), sodium tert-butoxide (4.5 g) and ethylene glycol dimethyl ether (100 ml) are added in turn. The above mixture is stirred and heated to reflux, and the above mixture is reacted under refluxing for 2.5 h. The completion of reaction is checked with TCL analysis. The reaction mixture is cooled to room temperature. After filtration, a filter cake is completely washed with ethylene glycol dimethyl ether for 2 times, and a filtrate is concentrated to dry and the residue is purified by column chromatography on silica gel to obtain a conjugate (11.0 g). The yield is about 88.8% on the basis of aminoquinoline.
  • 22
  • [ 75959-08-9 ]
  • [ 1080640-70-5 ]
  • 23
  • [ 75959-08-9 ]
  • CH4O3S*C18H17N7O [ No CAS ]
 

Historical Records

Technical Information

Categories

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[ 75959-08-9 ]

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Related Parent Nucleus of
[ 75959-08-9 ]

Quinolines

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