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Chemical Structure| 754177-25-8 Chemical Structure| 754177-25-8

Structure of 754177-25-8

Chemical Structure| 754177-25-8

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Product Details of [ 754177-25-8 ]

CAS No. :754177-25-8
Formula : C10H19NO2
M.W : 185.26
SMILES Code : CC(C)(C)OC(=O)CC1CCCN1
MDL No. :MFCD06738878

Safety of [ 754177-25-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 754177-25-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 754177-25-8 ]

[ 754177-25-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 59237-53-5 ]
  • [ 754177-25-8 ]
  • [ 1236119-54-2 ]
YieldReaction ConditionsOperation in experiment
91% With potassium carbonate; In tetrahydrofuran; at 20℃; for 1h;Inert atmosphere; Tert-butyl 2-(pyrrolidin-2-yl)acetate (1.00 g, 5.40 mmol) was added to a solution of <strong>[59237-53-5]methyl 6-chloro-5-nitronicotinate</strong> (1.169 g, 5.40 mmol) in THF (Volume: 10 ml). The reaction mixture was stirred at rt for 1 h and K2CO3 (0.760 g, 5.50 mmol) was added. The reaction mixture was stirred for 2 h and triethylamine (0.379 ml, 2.70 mmol) was added. The mixture was stirred for 1 h, filtered and concentrated in vacuo. Flash column chromatography on silica gel (120 g SiO2, hexanes:ethyl acetate 9:1) afforded methyl 6-(2-(2-tert-butoxy-2-oxoethyl)pyrrolidin-1-yl)-5-nitronicotinate (1.79 g, 4.90 mmol, 91percent yield) as a yellow oil. [M+H] calc'd for C17H23N3O6, 365; found, 365.
 

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