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Chemical Structure| 75415-78-0 Chemical Structure| 75415-78-0

Structure of 75415-78-0

Chemical Structure| 75415-78-0

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Product Details of [ 75415-78-0 ]

CAS No. :75415-78-0
Formula : C5H6Br2
M.W : 225.91
SMILES Code : BrC1=C(Br)CCC1
MDL No. :MFCD00010246
InChI Key :PNWFXPGGROADNS-UHFFFAOYSA-N
Pubchem ID :4438528

Safety of [ 75415-78-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H227-H302+H332-H318
Precautionary Statements:P210-P261-P264-P270-P271-P280-P301+P312+P330-P304+P340+P312-P305+P351+P338+P310-P370+P378-P403+P235-P501
Class:9
UN#:3334
Packing Group:

Application In Synthesis of [ 75415-78-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 75415-78-0 ]

[ 75415-78-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 75415-78-0 ]
  • [ 612832-83-4 ]
  • [ 612833-47-3 ]
YieldReaction ConditionsOperation in experiment
62% With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; toluene; at 90℃; for 2h; General Procedure C General Procedure C (i) 1-Bromo-2- (2-benzyloxy-5-chlorophenyl) cyclopentene A mixture of 1, 2-dibromocyclopentene (1.72 g, 7.6 mmol), 2-benzyloxy-5- chlorophenylboronic acid (500 mg, 1.9 mmol), potassium carbonate (2.1 g, 15.2 mmol) and tetrakis (triphenyl phosphine) palladium (0) (220 mg, 0.19 mmol) was stirred and heated in 1: 1 toluene/ethanol (15 ml) at 90C under nitrogen for 2 hours. After cooling the mixture was diluted with diethyl ether/water and the organic phase dried (magnesium sulphate), evaporated to dryness and the residue purified by chromatography on silica ( 2% ethyl acetate in iso-hexane then 10% dichloromethane in iso-hexane) to yield the title compound as a white solid (427 mg, 62%). 'H NMR (CDCI3) 6 : 1.99-2. 07 (2H, m), 2.67-2. 72 (2H, m), 2.76-2. 81 (2H, m), 5.06 (2H, s), 6.85 (1H, d, J=9Hz), 7.17-7. 38 (7H, m).
 

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