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Chemical Structure| 752242-28-7 Chemical Structure| 752242-28-7

Structure of 752242-28-7

Chemical Structure| 752242-28-7

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Product Details of [ 752242-28-7 ]

CAS No. :752242-28-7
Formula : C13H14N2O3S
M.W : 278.33
SMILES Code : O=C(NC1=NC=CS1)C2=CC(OC(C)C)=CC(O)=C2

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Application In Synthesis of [ 752242-28-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 752242-28-7 ]

[ 752242-28-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 234082-35-0 ]
  • [ 752242-28-7 ]
  • [ 863454-72-2 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In acetonitrile; at 160℃; for 0.5h;Microwave irradiation; Methyl 3-chloro-4-({3-[(1-methylethyl)oxy]-5-[(1,3-thiazol-2-ylamino)carbonyl]phenyl} oxy) benzoate; To a solution of 3-hydroxy-5-[(1-metl1ylethyl) oxy]-N-1, 3-thiazol-2-ylbenzamide (208 mg) and <strong>[234082-35-0]methyl 3-chloro-4-fluorobenzoate</strong> (141 mg) in acetonitrile (5 mL) was added potassium carbonate (104 mg) and the stirred mixture heated at 160C in a'Smith Creator Microwave' for 30 minutes. The mixture allowed to return to ambient temperature and pressure, the acetonitrile evaporated, and the residue partitioned between ethyl acetate (50 mL) and water (20 mL). The organic layer was separated, washed with brine, dried (MgS04), and evaporated to a residue which was chromatographed on silica, eluting with 30% ethyl acetate in isohexane, to give the desired ester (178 mg). 'H NMR 8 (CDC13) : 1.3 (d, 6H), 3.9 (s, 3H), 4.5-4. 6 (m, 1H), 6.75 (t, 1H), 6.95 (d, 1H), 7.0 (d, 1H), 7.1 (s, 1H), 7.2 (m, 1H), 7.3 (s, 1H), 7.9 (dd, 1H), 8. 05 (d, 1H) ; m/z 447 (M+H) +
 

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