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Chemical Structure| 7518-70-9 Chemical Structure| 7518-70-9

Structure of 7518-70-9

Chemical Structure| 7518-70-9

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Product Details of [ 7518-70-9 ]

CAS No. :7518-70-9
Formula : C4H10O2
M.W : 90.12
SMILES Code : CC(O)OCC
MDL No. :N/A

Safety of [ 7518-70-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H319-H225
Precautionary Statements:P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235
Class:3
UN#:1993
Packing Group:

Application In Synthesis of [ 7518-70-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7518-70-9 ]

[ 7518-70-9 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 7518-70-9 ]
  • [ 3575-32-4 ]
  • [ 214476-68-3 ]
  • 4-(3-dimethylamino-phenylamino)-5,8-dimethoxy-quinoline-3-carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyridine; EXAMPLE 242 4-(3-Dimethylamino-phenylamino)-5,8-dimethoxy-quinoline-3-carbonitrile A mixture of 0.148 g of 4-chloro-5,8-dimethoxy-3-quinolinecarbonitrile, 0.146 g of <strong>[3575-32-4]N,N-dimethyl-1,3-phenylenediamine dihydrochloride</strong>, 0.2 ml of pyridine, and 5 ml of ethoxyethanol was stirred under nitrogen, at reflux temperature for 30 minutes. Then the mixture was partitioned between ethyl acetate and saturated sodium chloride solution. The organic layer was dried and concentrated in vacuo. The residue thus obtained was chromatographed on silica gel eluding with ethyl acetate. Solvent was removed from product fractions giving 0.160 g of 4-(3-dimethylamino-phenylamino)-5,8-dimethoxy-quinoline-3-carbonitrile as a solid, mp 103-105 C.; mass spectrum (EI, m/e): M 348.1588.
With pyridine; Example 242 4-(3-Dimethylamino-phenylamino)-5,8-dimethoxy-quinoline-3-carbonitrile A mixture of 0.148 g of 4-chloro-5,8-dimethoxy-3-quinolinecarbonitrile, 0.146 g of <strong>[3575-32-4]N,N-dimethyl-1,3-phenylenediamine dihydrochloride</strong>, 0.2 ml of pyridine, and 5 ml of ethoxyethanol was stirred under nitrogen, at reflux temperature for 30 minutes. Then the mixture was partitioned between ethyl acetate and saturated sodium chloride solution. The organic layer was dried and concentrated in vacuo. The residue thus obtained was chromatographed on silica gel eluding with ethyl acetate. Solvent was removed from product fractions giving 0.160 g of 4-(3-dimethylamino-phenylamino)-5,8-dimethoxy-quinoline-3-carbonitrile as a solid, mp 103-105C; mass spectrum (EI, m/e): M 348.1588.
  • 2
  • [ 7518-70-9 ]
  • [ 84478-72-8 ]
  • [ 214470-55-0 ]
  • 4-(4-chloro-2-fluoro-5-hydroxy-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyridine hydrochloride; sodium carbonate; In water; 4-(4-Chloro-2-fluoro-5-hydroxy-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile A mixture of 0.25 g of 4-chloro-6,7-dimethoxy-3-quinolinecarbonitrile, 0.195 g of <strong>[84478-72-8]4-chloro-2-fluoro-5-hydroxyaniline</strong>, 0.116 g of pyridine hydrochloride, and 3 ml of ethoxyethanol was stirred under nitrogen, at reflux temperature for 1 h. The mixture was cooled and added to 10 ml of water. To this mixture was added sodium carbonate until pH 9. The product was collected, washed with water, and dried to give 0.327 g of 4-(4-chloro-2-fluoro-5-hydroxy-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile as a solid, dec>260 C.; mass spectrum (electrospray, m/e): M+H 373.9.
With pyridine hydrochloride; sodium carbonate; In water; 4-(4-Chloro-2-fluoro-5-hydroxy-phenylamino)-6,7-dimethoxyquinoline-3-carbonitrile A mixture of 0.25 g of 4-chloro-6,7-dimethoxy-3-quinolinecarbonitrile, 0.195 g of <strong>[84478-72-8]4-chloro-2-fluoro-5-hydroxyaniline</strong>, 0.116 g of pyridine hydrochloride, and 3 ml of ethoxyethanol was stirred under nitrogen, at reflux temperature for 1 h. The mixture was cooled and added to 10 ml of water. To this mixture was added sodium carbonate until pH 9. The product was collected, washed with water, and dried to give 0.327 g of 4-(4-chloro-2-fluoro-5-hydroxy-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile as a solid, dec >260 C.; mass spectrum (electrospray, m/e): M+H 373.9.
With pyridine hydrochloride; sodium carbonate; In water; Example 319 4-(4-Chloro-2-fluoro-5-hydroxy-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile A mixture of 0.25 g of 4-chloro-6,7-dimethoxy-3-quinolinecarbonitrile, 0.195 g of <strong>[84478-72-8]4-chloro-2-fluoro-5-hydroxyaniline</strong>, 0.116 g of pyridine hydrochloride, and 3 ml of ethoxyethanol was stirred under nitrogen, at reflux temperature for 1 h. The mixture was cooled and added to 10 ml of water. To this mixture was added sodium carbonate until pH 9. The product was collected, washed with water, and dried to give 0.327g of 4-(4-chloro-2-fluoro-5-hydroxy-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile as a solid, dec > 260C; mass spectrum (electrospray, m/e): M+H 373.9.
  • 3
  • [ 7518-70-9 ]
  • [ 3575-32-4 ]
  • [ 214476-63-8 ]
  • 4-(3-Dimethylamino-phenylamino)-6.7.8-trimethoxy-quinoline-3-carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyridine; sodium carbonate; In water; EXAMPLE 232 4-(3-Dimethylamino-phenylamino)-6.7.8-trimethoxy-quinoline-3-carbonitrile A mixture of 0.279 g of 4-chloro-6,7,8-trimethoxy-quinoline-3-carbonitrile, 0.23 g of <strong>[3575-32-4]N,N-dimethyl-1,3-phenylenediamine dihydrochloride</strong>, 0.2 ml of pyridine, and 15 ml of ethoxyethanol was stirred under nitrogen, at reflux temperature for 30 minutes. The mixture was cooled and added to 100 ml of water. To this mixture was added sodium carbonate to pH 9. The product was collected, washed with water, and dried to give 0.251 g of 4-(3-dimethylamino-phenylamino)-6,7,8-trimethoxy-quinoline-3-carbonitrile as a solid, mp 142-144 C.; mass spectrum (EI, m/e): M 378.1685.
With pyridine; sodium carbonate; In water; Example 232 4-(3-Dimethylamino-phenylamino)-6,7,8-trimethoxy-quinoline-3-carbonitrile A mixture of 0.279 g of 4-chloro-6,7,8-trimethoxy-quinoline-3-carbonitrile, 0.23 g of <strong>[3575-32-4]N,N-dimethyl-1,3-phenylenediamine dihydrochloride</strong>, 0.2 ml of pyridine, and 15 ml of ethoxyethanol was stirred under nitrogen, at reflux temperature for 30 minutes. The mixture was cooled and added to 100 ml of water. To this mixture was added sodium carbonate to pH 9. The product was collected, washed with water, and dried to give 0.251 g of 4-(3-dimethylamino-phenylamino)-6,7,8-trimethoxy-quinoline-3-carbonitrile as a solid, mp 142-144C; mass spectrum (EI, m/e): M 378.1685.
  • 4
  • [ 56354-98-4 ]
  • [ 7518-70-9 ]
  • [ 214470-55-0 ]
  • 6,7-dimethoxy-4-(2-oxo-2,3-dihydro-benzothiazol-6-ylamino)-quinoline-3-carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; pyridine hydrochloride; sodium carbonate; In water; EXAMPLE 131 6,7-Dimethoxy-4-(2-oxo-2,3-dihydro-benzothiazol-6-ylamino)-quinoline-3-carbonitrile A mixture of 0.249 g of 4-chloro-6,7-dimethoxy-quinolin-3-carbonitrile, 0.166 g of <strong>[56354-98-4]6-amino-2-benzothiazolinone</strong>, 0.020 g of pyridine hydrochloride, and 10 ml of ethoxyethanol was stirred under nitrogen, at reflux temperature for 20 minutes. The mixture was cooled and added to 40 ml of water. To this mixture was added sodium carbonate and concentrated hydrochloric acid to adjust pH to 7. The product was collected, washed with water, and dried to give 0.326 g of 6,7-dimethoxy-4-(2-oxo-2,3-dihydro-benzothiazol-6-ylamino)-quinoline-3-carbonitrile as a solid, mp 285-287 C.; mass spectrum (electrospray, m/e): M+H 379.0858.
 

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