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Chemical Structure| 7517-19-3 Chemical Structure| 7517-19-3
Chemical Structure| 7517-19-3

H-Leu-OMe·HCl

CAS No.: 7517-19-3

H-Leu-OMe·HCl is a leucine derivative, commonly used as a biochemical reagent and pharmaceutical intermediate.

Synonyms: H-Leu-OMe.HCl

4.5 *For Research Use Only !

Cat. No.: A122432 Purity: 96%

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Product Details of H-Leu-OMe·HCl

CAS No. :7517-19-3
Formula : C7H16ClNO2
M.W : 181.66
SMILES Code : N[C@@H](CC(C)C)C(OC)=O.[H]Cl
Synonyms :
H-Leu-OMe.HCl
MDL No. :MFCD00012494
InChI Key :DODCBMODXGJOKD-RGMNGODLSA-N
Pubchem ID :2723695

Safety of H-Leu-OMe·HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of H-Leu-OMe·HCl

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7517-19-3 ]

[ 7517-19-3 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 13211-32-0 ]
  • [ 7517-19-3 ]
  • [ 16071-39-9 ]
  • 2
  • [ 7517-19-3 ]
  • [ 107259-06-3 ]
  • (S)-2-[(1-tert-Butoxycarbonylamino-cyclopropylmethyl)-amino]-4-methyl-pentanoic acid methyl ester [ No CAS ]
  • 3
  • [ 954147-36-5 ]
  • [ 7517-19-3 ]
  • Fmoc-Glu(tetrazole)-Leu-OMe [ No CAS ]
  • 4
  • [ 7517-19-3 ]
  • [ 52558-24-4 ]
  • C15H28N2O6 [ No CAS ]
  • 5
  • [ 7517-19-3 ]
  • [ 53308-95-5 ]
  • [ 78664-45-6 ]
YieldReaction ConditionsOperation in experiment
75% With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; General procedure: To a cooled solution of Boc-L-leucine (1.0 equiv.), the amine/alpha-aminoester HCl (1.2-1.5 equiv.), and PyBop 1.2 equiv. (or EDCI*HCl1.2 equiv. and HOBt 1.2 equiv.) in anhydrous DMF was added diisopropylethylamine (3.3-4.0 equiv.) gradually. The reaction mixture was stirred at room temperature for 5 h to overnight, diluted with ethyl acetate (50 mL for every 5 mL DMF), then extracted with 1 M HCl (3), saturated sodium bicarbonate (3), and brine (2). The organic layer was then dried with anhydrous sodium sulfate and the solvent was evaporated under vacuum to give the products which were purified by flash chromatography whenever needed.
 

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