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Chemical Structure| 74912-33-7 Chemical Structure| 74912-33-7

Structure of 74912-33-7

Chemical Structure| 74912-33-7

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Product Details of [ 74912-33-7 ]

CAS No. :74912-33-7
Formula : C9H14O
M.W : 138.21
SMILES Code : C=CCCC(CCC=C)=O
MDL No. :MFCD11054937
Boiling Point : No data available
InChI Key :YMNUETQQDKREEP-UHFFFAOYSA-N
Pubchem ID :11083958

Safety of [ 74912-33-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319
Precautionary Statements:P264-P280-P305+P351+P338-P337+P313

Application In Synthesis of [ 74912-33-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 74912-33-7 ]

[ 74912-33-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 74912-33-7 ]
  • [ 38573-88-5 ]
  • [ 1190363-06-4 ]
YieldReaction ConditionsOperation in experiment
55.3% 5-(2,3-difluorophenyl)nona-1,8-dien-5-ol. In an oven-dried 250 mL round-bottomed flask (t=g) was added 1-Bromo-2,3-difluorobenzene (2.304 mL, 20.58 mmol) in THF (60 mL) to give a colorless solution. After cooling to -78° C., BuLi (8.23 mL, 20.58 mmol) was added dropwise via syringe. The mixture was stirred at -78° C. for 20 minutes, and nona-1,8-dien-5-one (2.37 g, 17.15 mmol) (azeotroped with dry benzene) was added dropwise via canuula (plus 6 ml THF rinse). The mixture was warmed up to room temperature over 1 hour. Quenched with water and the THF solvent was stripped off. The remaining mixture was extracted with EtOAc. The layers were separated and the organic layer was washed with brine, dried with Na2SO4, and concentrated to a yellow oil. The residue was purified by FCC up to 35percent Et2O/hexane. The desired fractions were pooled and concentrated to the product as a colorless oil (2.39 g, 55.3percent). 1H NMR (400 MHz, CDCl3) delta 7.30-7.22 (m, 1H), 7.10-7.03 (m, 2H), 5.82-5.70 (m, 2H), 4.97-4.85 (m, 4H), 2.20-2.00 (m, 4H), 2.00-1.75 (m, 4H).
 

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