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Chemical Structure| 7487-88-9 Chemical Structure| 7487-88-9
Chemical Structure| 7487-88-9

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Product Details of Magnesium sulfate

CAS No. :7487-88-9
Formula : MgO4S
M.W : 120.37
SMILES Code : O=S([O-])([O-])=O.[Mg+2]
MDL No. :MFCD00011110
InChI Key :CSNNHWWHGAXBCP-UHFFFAOYSA-L
Pubchem ID :24083

Safety of Magnesium sulfate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H371
Precautionary Statements:P501-P260-P270-P264-P308+P311-P405

Application In Synthesis of Magnesium sulfate

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7487-88-9 ]

[ 7487-88-9 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 6375-65-1 ]
  • [ 7732-18-5 ]
  • [ 7487-88-9 ]
  • KMnO4 [ No CAS ]
  • [ 27489-27-6 ]
  • 2
  • [ 37074-38-7 ]
  • [ 7732-18-5 ]
  • [ 7487-88-9 ]
  • [ 89-20-3 ]
  • [ 7499-07-2 ]
  • 3
  • [ 60032-63-5 ]
  • [ 6192-52-5 ]
  • [ 7487-88-9 ]
  • [ 2296-23-3 ]
YieldReaction ConditionsOperation in experiment
With hydroxylamine hydrochloride; In 5,5-dimethyl-1,3-cyclohexadiene; REFERENCE EXAMPLE 12 4-Hydroxy-3-Iodo-Benzonitrile To a solution of 4-hydroxy-3-iodo-benzaldehyde (7.9 g, 31.8 mmol) (prepared by the method of Barnes at al.; J. Chem. Soc., 1950, 2824) in xylene (120 mL) was added hydroxylamine hydrochloride (2.34 g, 33.4 mmol), magnesium sulphate (12.7 g) and p-toluene sulphonic acid monohydrate (1.27 g, 6.4 mmol). The resulting mixture was heated to reflux and stirred at this temperature for 90 min. The reaction mixture was then allowed to cool to room temperature and filtered. The solid was washed with ethyl acetate then the combined filtrates concentrated. The residue was purified by flash chromatography (eluding with 30% ethyl acetate in hexanes) to give 6.57 g of the title compound. 1H NMR (CDCl3) d 6.1 (bs, 1H), 7.05 (d, J=8 Hz, 1H), 7.55 (dd, J=8, 1 Hz, 1H), 7.99 (d, J=1 Hz, 1H).
  • 4
  • [ 3512-75-2 ]
  • ethereal hydrogen chloride [ No CAS ]
  • [ 7487-88-9 ]
  • [ 193001-81-9 ]
YieldReaction ConditionsOperation in experiment
90% In (2-hydroxyethyl)(methyl)amine; ethyl acetate; The starting material was prepared as follows: A solution of <strong>[3512-75-2]4-chloro-2,6-dimethylpyridine</strong> (849 mg, 6 mmol), (J. Het. Chem. 1990, 1841), in 2-(methylamino)ethanol (1.35 g, 18 mmol) and 3M ethereal hydrogen chloride (3 drops) was heated at 140° C. for 1 hour. The reaction mixture was allowed to cool and was diluted with water. The insolubles were removed by filtration and the aqueous filtrate was poured onto a suspension of magnesium sulphate (50 g) in ethyl acetate (100 ml). The insolubles were removed by filtration and the filtrate dried (MgSO4) and the solvent removed by evaporation. The solid residue was triturated with ether, collected by filtration and dried under vacuum at 50° C. to give 2-(N-(2,6-dimethyl-4-pyridyl)-N-methylamino)ethanol (960 mg, 90percent). m.p. 139-144° C. 1 H NMR Spectrum: (CDCl3) 2.4(s, 6H); 3.0(s, 3H); 3.51 (t, 2H); 3.81 (t, 2H); 6.26(s, 2H) MS - ESI: 181 [MH]+
  • 5
  • 4-amino-2-(4,6-dimethoxypyrimidin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one [ No CAS ]
  • [ 7487-88-9 ]
  • [ 26638-43-7 ]
  • 4-[bis-(2-methoxycarbonylphenylsulphonyl)-amino]-2-(4,6-dimethoxy-pyrimidin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyridine; In dichloromethane; (Process (a)) A mixture of 7.2 g (0.03 mol) of 4-amino-2-(4,6-dimethoxypyrimidin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, 21.0 g (0.09 mol) of 2-methoxycarbonyl-benzenesulphonyl chloride and 50 ml of pyridine is stirred at 20 C. for 12 hours. The mixture is subsequently concentrated under a waterpump vacuum, and the residue is taken up in methylene chloride and washed with 2N hydrochloric acid. The mixture is dried using magnesium sulphate and then filtered, and the solvent is carefully distilled off from the filtrate under a waterpump vacuum. 12.0 g (63% of theory) of 4-[bis-(2-methoxycarbonylphenylsulphonyl)-amino]-2-(4,6-dimethoxy-pyrimidin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one are obtained as a crystalline residue of melting point 176 C.
  • 6
  • 4-amino-5-methyl-2-(4,6-dimethoxy-pyrimidin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one [ No CAS ]
  • [ 7487-88-9 ]
  • [ 26638-43-7 ]
  • 4-(2-methoxycarbonyl-phenylsulphonylamino)-5-methyl-2-(4,6-dimethoxy-pyrimidin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyridine; hydrogenchloride; (Process (a)) A mixture of 4.2 g (0.016 mol) of 4-amino-5-methyl-2-(4,6-dimethoxy-pyrimidin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, 11.7 g (0.05 mol) of 2-methoxycarbonylbenzenesulphonyl chloride and 50 ml of pyridine is stirred at 20 C. for 12 hours, then diluted with ice-water and acidified using 2N hydrochloric acid, and the mixture is shaken with methylene chloride. The organic phase is separated off, dried using magnesium sulphate and filtered. The solvent is carefully distilled off from the filtrate under a waterpump vacuum. 3.8 g (50% of theory) of 4-(2-methoxycarbonyl-phenylsulphonylamino)-5-methyl-2-(4,6-dimethoxy-pyrimidin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one are obtained as a crystalline residue of melting point 174 C.
  • 7
  • 4-amino-5-methylthio-2-(4,6-dimethoxy-pyrimidin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one [ No CAS ]
  • [ 7487-88-9 ]
  • [ 26638-43-7 ]
  • 4-(2-methoxycarbonyl-phenylsulphonylamino)-5-methylthio-2-(4,6-dimethoxy-pyrimidin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyridine; hydrogenchloride; In methanol; dichloromethane; (Process (a)) A mixture of 5.7 g (0.02 mol) of 4-amino-5-methylthio-2-(4,6-dimethoxy-pyrimidin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one, 14.0 g (0.06 mol) of 2-methoxycarbonylbenzenesulphonyl chloride and 50 ml of pyridine is stirred at 20 C. for 48 hours. The mixture is subsequently concentrated under a waterpump vacuum, the residue is taken up in methylene chloride, and the mixture is washed using 2N hydrochloric acid, dried using magnesium sulphate and filtered. The filtrate is concentrated and the residue is purified by column chromatography on silica gel using methylene chloride/methanol (vol. 10:1). 3.0 g (31% of theory) of 4-(2-methoxycarbonyl-phenylsulphonylamino)-5-methylthio-2-(4,6-dimethoxy-pyrimidin-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one of melting point 179 C. are obtained.
 

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