74494-52-3|3-Piperidineacetic acid| Ambeed

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Quality Control of [ 74494-52-3 ] Purity: 98% SDS Specification

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Product Details of [ 74494-52-3 ]

CAS No. :	74494-52-3
Formula :	C₇H₁₃NO₂
M.W :	143.18
SMILES Code :	O=C(O)CC1CNCCC1
MDL No. :	MFCD06410646
InChI Key :	WKXRHAACRPUBIC-UHFFFAOYSA-N
Pubchem ID :	283696

Safety of [ 74494-52-3 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H319-H302-H335-H315
Precautionary Statements:	P304+P340-P302+P352-P305+P351+P338-P301+P312-P261

Application In Synthesis of [ 74494-52-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 74494-52-3 ]

[ 74494-52-3 ] Synthesis Path-Downstream 1~23

1
[ 74494-52-3 ]
3-(2-hydroxyethyl)piperidine [ No CAS ]

References: [1]Helvetica Chimica Acta,1987,vol. 70,p. 1981 - 1987.

3
[ 501-81-5 ]
[ 74494-52-3 ]

Yield	Reaction Conditions	Operation in experiment
81%	With hydrogen;platinum(IV) oxide; In acetic acid; at 20℃; for 16h;	To a solution of 2-(pyridin-3-yl)acetic acid (274 mg, 2.0 mmol, 1.0 eq) in AcOH (2 niL) was added Pt02 (226 mg, 1.0 mmol, 0.5 eq). The mixture was stirred at room temperature for 16 h under H2. The catalyst was filtered out and the filtrate was concentrated to give 2-(piperidin-3-yl)acetic acid as a slight yellow solid (300 mg, Y: 81%). ESI-MS (M+H)+: 143.1. 1H NMR (400 MHz, CD3OD) δ: 3.34-3.31 (m, IH), 2.84- 2.77 (m, IH), 2.64-2.57 (m, 3H ), 2.18-2.10 (m, 3H), 1.86-1.83 (m, 2H), 1.71-1.67 (m, IH), 1.24-1.22 (m, IH).

References: [1]Patent: WO2012/109108,2012,A1 .Location in patent: Page/Page column 114.
[2]European Journal of Medicinal Chemistry,1999,vol. 34,p. 363 - 380.

4
[ 24424-99-5 ]
[ 74494-52-3 ]
[ 183483-09-2 ]

References: [1]European Journal of Medicinal Chemistry,1999,vol. 34,p. 363 - 380.

5
[ 74494-52-3 ]
(2R)-N-methyl-2-(N-methyl-N-((2R)-2-(N-methyl-N-(((3S)-piperidin-3-yl)acetyl)amino)-3-(2-naphthyl)propionyl)amino)-3-phenylpropionamide [ No CAS ]

References: [1]European Journal of Medicinal Chemistry,1999,vol. 34,p. 363 - 380.

6
[ 74494-52-3 ]
(2R)-N-methyl-2-(N-methyl-N-((2R)-2-(N-methyl-N-(((3R)-piperidin-3-yl)acetyl)amino)-3-(2-naphthyl)propionyl)amino)-3-phenylpropionamide [ No CAS ]

References: [1]European Journal of Medicinal Chemistry,1999,vol. 34,p. 363 - 380.

7
[ 74494-52-3 ]
3-[(methyl-{1-[methyl-(1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-methyl]-piperidine-1-carboxylic acid <i>tert</i>-butyl ester [ No CAS ]

References: [1]European Journal of Medicinal Chemistry,1999,vol. 34,p. 363 - 380.

8
[ 74494-52-3 ]
(+)-(R)-1-Azabicyclo<3.3.1>nonan-2-on [ No CAS ]

References: [1]Helvetica Chimica Acta,1987,vol. 70,p. 1981 - 1987.

9
[ 74494-52-3 ]
[ 115909-93-8 ]

References: [1]Helvetica Chimica Acta,1987,vol. 70,p. 1981 - 1987.

10
[ 74494-52-3 ]
[ 115909-95-0 ]

References: [1]Helvetica Chimica Acta,1987,vol. 70,p. 1981 - 1987.

11
[ 74494-52-3 ]
(+)-(R)-Piperidin-3-propionitril-hydrochlorid [ No CAS ]

References: [1]Helvetica Chimica Acta,1987,vol. 70,p. 1981 - 1987.

12
[ 74494-52-3 ]
(+)-(R)-Piperidin-3-propionsaeure-hydrochlorid [ No CAS ]

References: [1]Helvetica Chimica Acta,1987,vol. 70,p. 1981 - 1987.

13
[ 74494-52-3 ]
[ 115909-94-9 ]

References: [1]Helvetica Chimica Acta,1987,vol. 70,p. 1981 - 1987.

14
[ 74494-52-3 ]
[ 115909-92-7 ]

References: [1]Helvetica Chimica Acta,1987,vol. 70,p. 1981 - 1987.

15
[ 64119-42-2 ]
[ 74494-52-3 ]
[ 898229-67-9 ]

Yield	Reaction Conditions	Operation in experiment
54%	With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 3h;	(b) { 1-[3-Cyano-5-(ethoxycarbonyl)-6-inethylpyridin-2-yI]piperdin-3-yl}acetic acid; Ethyl 6-chloro-5-cyano-2-methylnicotinate (1.00 g, 4.45 mmol), piperidin-3-ylacetic acid (0.701 g, 4.90 mmol) and DIPEA (2.33 mL, 13.4 mmol) were dissolved in DMF (30 mL) and stirred at r.t for 3 days. The reaction mixture was diluted with EtOAc (100 mL), washed with saturated NH4Cl (2 x 25 mL), saturated NaHCO3 (2 x25 mL), brine (25 m), dried (Mg5O4) and concentrated under reduced pressure to afford crude material. Flash chromatography (9:1 EPO <DP n="235"/>EtOAc/hexanes with 1% AcOH) gave {1-[3-cyano-5-(ethoxycarbonyl)-6-methylpyridin-2- yl]piperdin-3-yl}acetic acid as a solid. Yield: 0.791 g (54 %).1HNMR (400 MHz, CDCl3): 6 1.37 (3H, t, J= 7.1 Hz), 1.39-1.44 (1H, m), 1.63-1.73 (1H, m), 1.78-1.85 (1H, m), 1.98-2.03 (1H, m), 2.16-2.24 (1H, m), 2.29-2.34 (1H, m), 2.40-2.46 (1H, m), 2.71 (3H, s), 3.08-3.13 (1H, m), 3.26-3.32 (1H, m), 4.31 (2H, q, J= 7.1 Hz), 4.44- 4.50 (1H, m), 4.52-4.56 (1H, m), 8.33 (1H, s). M5 m/z: 330 (M-I).
54%	With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 3h;	(b) { 1-[3-Cyano-5-(ethoxycarbonyl)-6-inethylpyridin-2-yI]piperdin-3-yl}acetic acid; Ethyl 6-chloro-5-cyano-2-methylnicotinate (1.00 g, 4.45 mmol), piperidin-3-ylacetic acid (0.701 g, 4.90 mmol) and DIPEA (2.33 mL, 13.4 mmol) were dissolved in DMF (30 mL) and stirred at r.t for 3 days. The reaction mixture was diluted with EtOAc (100 mL), washed with saturated NH4Cl (2 x 25 mL), saturated NaHCO3 (2 x25 mL), brine (25 m), dried (Mg5O4) and concentrated under reduced pressure to afford crude material. Flash chromatography (9:1 EPO <DP n="235"/>EtOAc/hexanes with 1% AcOH) gave {1-[3-cyano-5-(ethoxycarbonyl)-6-methylpyridin-2- yl]piperdin-3-yl}acetic acid as a solid. Yield: 0.791 g (54 %).1HNMR (400 MHz, CDCl3): 6 1.37 (3H, t, J= 7.1 Hz), 1.39-1.44 (1H, m), 1.63-1.73 (1H, m), 1.78-1.85 (1H, m), 1.98-2.03 (1H, m), 2.16-2.24 (1H, m), 2.29-2.34 (1H, m), 2.40-2.46 (1H, m), 2.71 (3H, s), 3.08-3.13 (1H, m), 3.26-3.32 (1H, m), 4.31 (2H, q, J= 7.1 Hz), 4.44- 4.50 (1H, m), 4.52-4.56 (1H, m), 8.33 (1H, s). M5 m/z: 330 (M-I).

References: [1]Patent: WO2006/73361,2006,A1 .Location in patent: Page/Page column 233-234.
[2]Patent: WO2006/73361,2006,A1 .Location in patent: Page/Page column 233-234.

Yield	Reaction Conditions	Operation in experiment
		A. 3-PIPERIDINYLACETIC ACID STR51 3-Pyridylacetic acid hydrochloride (13 grams) (74.9 mmoles) was hydrogenated as described in Preparative Example 7 to give a mixture of unreacted 3-pyridylacetic acid and the product compound (76:24) (8.63 grams, MH+

Yield	Reaction Conditions	Operation in experiment
		B. 1-N-ACETYL-3-PIPERIDINYLACETIC ACID STR44 The mixture of compounds from Preparative Example 4A (8.56 grams) are reacted with acetic anhydride (8.56 grams) as described in Preparative Example 3A and the crude mixture of products is diluted in methanol (60 ml) and passed over a bed of BioRad AG50WX4 resin (RSO3 H) and the latter is eluted with methanol. The eluates are evaporated to dryness to give the title compound (Yield: 1.23 grams, MH+

18
[ 74494-52-3 ]
[ 169253-07-0 ]

Yield	Reaction Conditions	Operation in experiment
	With acetic anhydride; In methanol;	B. 1-N-ACETYL-3-PIPERIDINYLACETIC ACID STR52 The mixture of compounds from Preparative Example 10A (8.56 grams) were reacted with acetic anhydride (8.56 grams) as described in Preparative Example 5A and the crude mixture of products was taken up in MeOH (60 ml) and passed over a bed of BioRad AG50WX4 resin (RSO3 H) and the latter was eluted with MeOH. The eluates were evaporated to dryness to give the product compound (Yield: 1.23 grams, MH+
	With acetic anhydride; In methanol;	B. 1-N-ACETYL-3-PIPERIDINYLACETIC ACID STR62 The mixture of compounds from Preparative Example 6A (8.56 grams) were reacted with acetic anhydride (8.56 grams) as described in Preparative Example 5B and the crude mixture of products was diluted in methanol (60 ml) and passed over a bed of BioRad AG50WX4 resin (RSO3 H) and the latter was eluted with methanol. The eluates were evaporated to dryness to give the title compound (Yield: 1.23 grams, MH+ 186).
	With acetic anhydride; In methanol;	B. 1-N-ACETYL-3-PIPERIDINYLACETIC ACID STR148 The mixture of compounds from Preparative Example 18A (8.56 grams) were reacted with acetic anhydride (8.56 grams) as described in Preparative Example 13A and the crude mixture of products was taken up in MeOH (60 ml) and passed over a bed of BioRad AG50WX4 resin (RSO3 H) and the latter was eluted with MeOH. The eluates were evaporated to dryness to give the title compound (Yield: 1.23 grams, MH+ 186).

References: [1]Patent: US5891872,1999,A .
[2]Patent: US5672611,1997,A .
[3]Patent: US5719148,1998,A .

19
[ 74494-52-3 ]
3-piperidineacetic acid ethyl ester hydrochloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; In diethyl ether; ethanol;	STR21 A suspension of <strong>[74494-52-3]3-piperidineacetic acid</strong> (4.5 g, 0.032 mol, described in J. Org. Chem., 2a, 602, 1963) in a mixture of dry hydrogen chloride (excess) in ethanol was stirred at ambient temperature. When the solid was dissolved, the solution was stirred for 2 days. The solvent was evaporated invacuo and the residue was reevaporated with diethyl ether (25 ml) and then stirred with diethyl ether (35 ml) for 20 minutes. The solid was isolated by filtration and dried. This afforded 6.1 g of <strong>[74494-52-3]3-piperidineacetic acid</strong> ethyl ester hydrochloride as a solid. M.p. 111-113 C.
	With hydrogenchloride; In diethyl ether; ethanol;	Example 18 1-(3-(10,11-Dihydro-5H-dibenz[b,f]azepin-5-yl)-1-propyl)-<strong>[74494-52-3]3-piperidineacetic acid</strong> hydrochloride A suspension of <strong>[74494-52-3]3-piperidineacetic acid</strong> (4.5 g, 0.032 mol, described in J. Org. Chem., 28, 602, 1963) in a mixture of dry hydrogen chloride (excess) in ethanol was stirred at ambient temperature. When the solid was dissolved, the solution was stirred for 2 days. The solvent was evaporated in vacuo and the residue was reevaporated with diethyl ether (25 ml) and then stirred with diethyl ether (35 ml) for 20 minutes. The solid was isolated by filtration and dried. This afforded 6.1 g of <strong>[74494-52-3]3-piperidineacetic acid</strong> ethyl ester hydrochloride as a solid. M.p. 111-113 C.

References: [1]Patent: US6071901,2000,A .
[2]Patent: US6239148,2001,B1 .

20
[ 501-81-5 ]
[ 74494-52-3 ]
[ 501-53-1 ]
[ 86827-10-3 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; H2; sodium hydroxide; In water;	C. 1-[(Phenylmethoxy)carbonyl]-<strong>[74494-52-3]3-piperidineacetic acid</strong> Platinum oxide (300 mg, Alfa) was added to a solution of 3-pyridyl acetic acid (3.3 g, 24.08 mmol) in water (120 mL) and conc. HCl (2.5 mL). The solution was hydrogenated at up to 50 psi of H2 pressure for 6.5 hrs. The catalyst was removed by filtration through a pad of Celite and the pad was washed with more water. The stirred aqueous solution of the 3-piperidine acetic acid was cooled (0-5 C.) and treated with 5 N aqueous NaOH solution (20 mL). Benzyl chloroformate (4 mL) was added dropwise to the cooled, stirred solution. During the ten minute addition, the pH was maintained between 10 and 12 by addition of NaOH solution. After one hour the reaction mixture was extracted with ether (2100 mL). The ether extracts were discarded and the aqueous layer was acidified with 2 N HCl solution. The acidified aqueous layer was then extracted with ethyl acetate (2100 mL). The combined extracts were dried over magnesium sulfate and concentrated in vacuo to give title compound as an oil (7.0 g, contained EtOAc).

References: [1]Patent: US5583146,1996,A .

21
[ 1265323-46-3 ]
[ 74494-52-3 ]
[ 1265322-06-2 ]

Yield	Reaction Conditions	Operation in experiment
		Example 222-(l-(2-Hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-l,2,4-oxadiazol-3- yl)phenyl)ethyl)piperidin-3-yl)acetic acid[00259] To a solution of <strong>[74494-52-3]2-(piperidin-3-yl)acetic acid</strong> (51 mg, 0.36 mmol) in 0.5 mL dry DMSO was added tetrabutylammonium hydroxide (0.360 mL, 360 μmol, IM inTHF) and the reaction mixture was stirred at room temperature for 15 min. 2-bromo-l- (4-(5-(5-phenyl-4-propylisoxazol-3-yl)-l,2,4-oxadiazol-3-yl)phenyl)ethanol, Preparation 1C (30 mg, 0.066 mmol) was dissolved in 0.5 mL DMSO and added and the reaction mixture was agitated at 400 rpm on an INNOVA platform shaker at 80 0C for 1.5 hours. The reaction was diluted with 250 μL of MeOH and purified by HPLC (MeOH-H2O-TFA) to give 2-(l-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-l,2,4-oxadiazol- 3-yl)phenyl)ethyl)piperidin-3-yl)acetic acid. MS (m+1) = 517. HPLC RT = 2.08 min using a Waters Masslynx instrument equipped with a 19x100 mm 5uM Cl 8 column and a method of 0-100% B solvent over 15 min at a flow rate of 20 mL/min. Solvent A is 5:95 acetonitrile/water; solvent B is 95:5 acetonitrile/water and both contain 0.5% TFA.

References: [1]Patent: WO2011/17578,2011,A1 .Location in patent: Page/Page column 123-124.

22
[ 1446358-48-0 ]
[ 74494-52-3 ]
C₂₄H₂₂F₂N₆O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
32%	With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; at 120℃; for 18h;	General procedure: General procedure B A solution of amino nucleophile (3 equiv.), triethylamine (10 equiv.), and Intermediate 1 (1 equiv.) was stirred in dioxane and water (2:1 ratio) at 90 C until complete consumption of starting material was observed by LC/MS. The solution was diluted withiN hydrochloric acid and dichloromethane. The layers were then separated and thelayer was extracted with dichloromethane. The organics were combined, dried over magnesium sulfate, filtered, and the solvent was removed in vacuo. Purification yielded theproductThe title compound was prepared following general procedure B, except <strong>[74494-52-3]2-(piperidin-3-yl)acetic acid</strong> was the amine reactant, 6 equivalents of Hunig’s base was used instead of triethylamine, and contents were heated to 120 C for 18 h as a solution in THF/water (10:1). Solvent was removed under a stream of nitrogen, and the resulting crude material was purified via reverse phase HPLC to deliver the desired compound, Compound 1-229 (8.1 mg, 32% yield) as a solid.1H NMR (500 MHz, CD3OD) ö ppm 8.84 (m, 1 H), 8.28 (m, 1 H), 7.73 (m, 1 H), 7.32 (m, 1 H),7.12 (m, 2 H), 6.98 (m, 2 H), 6.04 (s, 2 H), 4.96 (m, 1 H), 4.67 (m, 1 H), 3.54 (m, 1 H), 3.27 (m, 1 H), 2.42 (m, 2 H), 2.25 (m, 1 H), 2.00 (m, 2 H), 1.79 (m, 1 H), 1.54 (m, 1 H).

References: [1]Patent: WO2014/144100,2014,A2 .Location in patent: Paragraph 00274.

23
[ 1265323-46-3 ]
[ 74494-52-3 ]
[ 76-05-1 ]
2-(1-(2-hydroxy-2-(4-(5-(5-phenyl-4-propylisoxazol-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)acetic acid trifluoroacetate [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2016,vol. 59,p. 6248 - 6264.

Historical Records

Technical Information

• Arndt-Eistert Homologation • Hunsdiecker-Borodin Reaction • Passerini Reaction • Preparation of Amines • Preparation of Carboxylic Acids • Reactions of Amines • Reactions of Carboxylic Acids • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Ugi Reaction

Related Functional Groups of
[ 74494-52-3 ]

Carboxylic Acids

A415036 [1822-31-7]

3-(Piperidin-3-yl)propanoic acid

Similarity: 1.00

A571247 [887587-28-2]

2-(4-Methylpiperidin-3-yl)acetic acid

Similarity: 1.00

A120360 [71985-81-4]

2-(Piperidin-3-yl)acetic acid hydrochloride

Similarity: 0.97

A163854 [1334509-89-5]

(R)-2-(Piperidin-3-yl)acetic acid hydrochloride

Similarity: 0.97

A696564 [71985-82-5]

3-(Piperidin-3-yl)propanoic acid hydrochloride

Similarity: 0.97

Related Parent Nucleus of
[ 74494-52-3 ]

Piperidines

A415036 [1822-31-7]

3-(Piperidin-3-yl)propanoic acid

Similarity: 1.00

A571247 [887587-28-2]

2-(4-Methylpiperidin-3-yl)acetic acid

Similarity: 1.00

A120360 [71985-81-4]

2-(Piperidin-3-yl)acetic acid hydrochloride

Similarity: 0.97

A163854 [1334509-89-5]

(R)-2-(Piperidin-3-yl)acetic acid hydrochloride

Similarity: 0.97

A696564 [71985-82-5]

3-(Piperidin-3-yl)propanoic acid hydrochloride

Similarity: 0.97

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P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 74494-52-3

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