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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 74426-51-0 Chemical Structure| 74426-51-0

Structure of 74426-51-0

Chemical Structure| 74426-51-0

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Product Citations

Product Citations

Shameer M. Kondengadan ; Shubham Bansal ; Xiaoxiao Yang ; Binghe Wang ;

Abstract: Carbon monoxide (CO) is an endogenous produced molecule and has shown efficacy in animal models of inflammation, organ injury, colitis and cancer metastasis. Because of its gaseous nature, there is a need for developing efficient CO delivery approaches, especially those capable of targeted delivery. In this study, we aim to take advantage of a previously reported approach of enrichment-triggered prodrug activation to achieve targeted delivery by targeting the folate receptor. The general idea is to exploit folate receptor-mediated enrichment as a way to accelerate a biomolecular Diels-Alder reaction for prodrug activation. In doing so, we first need to find ways to tune the reaction kinetics in order to ensure minimal rection without enrichment and optimal activation upon enrichment. In this feasibility study, we synthesized two diene-dienophile pairs and studied their reaction kinetics and ability to target the folate receptor. We found that folate conjugation significantly affects the reaction kinetics of the original diene-dienophile pairs. Such information will be very useful in future designs of similar targeted approaches of CO delivery.

Keywords: Enrichment triggered delivery ; Carbon Monoxide ; Folate conjugate ; Reaction kinetics ; Diels-Alder reaction

Purchased from AmBeed: 7693-46-1 ; ; ;

Alternative Products

Product Details of [ 74426-51-0 ]

CAS No. :74426-51-0
Formula : C9H6ClF3O
M.W : 222.59
SMILES Code : O=C(Cl)CC1=CC=C(C(F)(F)F)C=C1
MDL No. :MFCD08458136
InChI Key :MLMKUFMLPHQPFO-UHFFFAOYSA-N
Pubchem ID :14810943

Safety of [ 74426-51-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P264-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310-P363-P405-P501
Class:8
UN#:3265
Packing Group:
 

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