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Chemical Structure| 743460-48-2 Chemical Structure| 743460-48-2

Structure of 743460-48-2

Chemical Structure| 743460-48-2

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Product Details of [ 743460-48-2 ]

CAS No. :743460-48-2
Formula : C21H27N3O2
M.W : 353.46
SMILES Code : O=C(OC1CCN(CCNC)CC1)NC2=CC=CC=C2C3=CC=CC=C3
MDL No. :MFCD31731124
InChI Key :KBDAVUJVUPXLAH-UHFFFAOYSA-N
Pubchem ID :56643603

Safety of [ 743460-48-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 743460-48-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 743460-48-2 ]

[ 743460-48-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 743460-48-2 ]
  • [ 85822-16-8 ]
  • [ 743461-19-0 ]
YieldReaction ConditionsOperation in experiment
62% With triethylamine; In dichloromethane; at 20℃; for 1h; Preparation 27 Biphenyl-2-ylcarbamic Acid 1-{2-[(4-Formylbenzenesulfonyl)methylamino]-ethyl}piperidin-4-yl Ester To a stirred solution of the product of Preparation 8 (350 mg, 1 mmol) and triethylamine (167 muL, 1.2 mmol) in dichloromethane (5 mL) was added <strong>[85822-16-8]4-formylbenzenesulfonyl chloride</strong> (225 mg, 1.1 mmol). After 1 h at room temperature, the reaction was complete by MS and the reaction mixture was then washed with saturated aqueous sodium bicarbonate solution (5 mL). The organic layer was then dried (Na2SO4) and solvent removed under reduced pressure to give the title intermediate (323 mg, 62% yield). MS m/z M+H+=522.4.
  • 2
  • [ 743460-48-2 ]
  • [ 775545-30-7 ]
  • C36H44N6O4*2C2HF3O2 [ No CAS ]
  • 3
  • [ 743460-48-2 ]
  • [ 775545-30-7 ]
  • C28H32N4O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
87% With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20℃; for 0.333333h; [1- [2- (methylamino) ethyl] -4-piperidinyl] N- (2-phenylphenyl) carbamate (0.35 g, 1 mmol) (9A) (Refer to J. Med. Chem., 2015, 58 (6), prepared by pp 2609-2622) was dissolved in dichloromethane (30 mL), and 6- (hydroxymethyl) pyridine-3-carboxylic acid (9B) ( 0.15g, 1mmol) (prepared from WO2013041535), after stirring, add triethylamine (0.2g, 2mmol) and HATU (0.57g, 1.5mmol) in order, and react at room temperature for 20 minutes. After the reaction was completed, a saturated aqueous sodium hydrogen carbonate solution (30 mL) was added, and the mixture was extracted with dichloromethane (30 mL × 2), washed with saturated brine (30 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography. Separation (dichloromethane / methanol (v / v) = 40: 1) gives [1- [2-[[6- (hydroxymethyl) pyridine-3-carbonyl] -methyl-amino] ethyl] -4 -Piperidinyl] N- (2-phenylphenyl) carbamate (29C), a colorless viscous substance (0.42 g, yield: 87%).
 

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