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Han, Xuexiang ; Xu, Ying ; Ricciardi, Adele , et al. bioRxiv,2025. DOI: 10.1101/2025.02.25.640222
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Abstract: mRNA-based gene editing therapeutics offer the potential to permanently cure diseases but are hindered by suboptimal delivery platforms. Here, we devise a robust combinatorial chemistry for plug-and-play assembly of diverse biodegradable ionizable lipids and identify a lead candidate that produces superior lipid nanoparticles for various gene editing tools delivery in vivo. Our study highlights the utility of this synthetic approach and the generality of this platform for potent in vivo gene editing.
Purchased from AmBeed: 142-16-5 ; 7423-42-9 ; 1122-58-3 ; 105-76-0 ; 2915-53-9
CAS No. : | 7423-42-9 | MDL No. : | MFCD00080510 |
Formula : | C12H20O4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | IQBLWPLYPNOTJC-FPLPWBNLSA-N |
M.W : | 228.28 | Pubchem ID : | 5365056 |
Synonyms : |
Signal Word: | Danger | Class: | N/A |
Precautionary Statements: | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362-P280-P305+P351+P338-P310-P264-P270-P301+P312-P330-P501-P261-P285-P304+P341-P342+P311-P501-P260-P314-P501-P273-P501 | UN#: | N/A |
Hazard Statements: | H373-H317-H412-H302-H315-H318-H334 | Packing Group: | N/A |
GHS Pictogram: | ![]() ![]() ![]() |