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Chemical Structure| 7390-62-7 Chemical Structure| 7390-62-7

Structure of Meradine
CAS No.: 7390-62-7

Chemical Structure| 7390-62-7

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Product Details of [ 7390-62-7 ]

CAS No. :7390-62-7
Formula : C5H5N5S
M.W : 167.19
SMILES Code : S=C1NC2=C(N)N=CN=C2N1
MDL No. :MFCD00127786
InChI Key :BHVOFCPOXNYVCE-UHFFFAOYSA-N
Pubchem ID :5354970

Safety of [ 7390-62-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 7390-62-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7390-62-7 ]

[ 7390-62-7 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 3032-81-3 ]
  • [ 7390-62-7 ]
  • 8-((3,5-dichlorophenyl)thio)-9H-purin-6-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
44% With copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; sodium t-butanolate; In N,N-dimethyl-formamide; at 110℃;Inert atmosphere; Sealed tube; 8-Mercaptoadenine (3.6 mmol), neocuproine hydrate (0.36 mmol), Cul (0.36 mmol), NaO-?-Bu (7.2 mmol), 3,5-dichloro-iodobenzene (10.8 mmol), and anhydrous DMF (24 mL) were added to a round bottom flask flushed with nitrogen. The flask was sealed with Teflon tape and heated at 1 10 °C with stirring for 24-36 h under nitrogen. Solvent was removed under reduced pressure and the resulting residue was chromatographed (CH2Cl2:MeOH:AcOH, 20: 1 :0.5) to yield 15 as a yellow solid in 44 percent yield. -NMR (400 MHz, DMSO-i/6) delta 13.49 (IH, br s), 8.13 (IH, s), 7.59 (IH, s), 7.47 (2H, s), 7.36 (2H, br s); MS (ESI): m/z 312.1 [M + H+].
  • 2
  • [ 175278-00-9 ]
  • [ 7390-62-7 ]
  • 8-(2-trifluoromethoxy-phenylsulfanyl)adenine [ No CAS ]
  • 3
  • [ 7390-62-7 ]
  • [ 3034-48-8 ]
  • [ 1147011-89-9 ]
  • 4
  • [ 175278-30-5 ]
  • [ 7390-62-7 ]
  • [ 1360066-70-1 ]
YieldReaction ConditionsOperation in experiment
49% With copper(l) iodide; tetrabutylammomium bromide; sodium t-butanolate; In N,N-dimethyl-formamide; at 150℃; for 1.5h;Sealed tube; Microwave irradiation; General procedure: In a conical-bottomed microwave vial, the mixture of 8 mercaptoadenine (0.1 mmol), respective aryl iodide (0.1 mmol), Cul (0.02 mmol), NaO?-Bu (0.3 mmol) and ?-butyl ammonium bromide (0.02 mmol) in DMF (2 mL) was charged. The sealed vial was irradiated in the microwave for 1.5 h at 150 °C. After cooling, the reaction mixture was condensed under reduced pressure and purified by flash chromatography (CH2Cl2:MeOH:AcOH, 20: 1 :0.5). [0216] 8-((4-Bromo-2-ethylphenyl)thio)-9H-purin-6-amine (2a). Obtained by method B as a light yellow solid in 49 percent yield. MS (ESI): m/z 351.8 [M + H]+.
  • 5
  • [ 175278-30-5 ]
  • [ 7390-62-7 ]
  • C18H18BrN5S [ No CAS ]
  • 8-((4-bromo-2-ethylphenyl)thio)-9-(pent-4-yn-1-yl)-9H-purin-6-amine [ No CAS ]
  • 6
  • [ 175278-00-9 ]
  • [ 7390-62-7 ]
  • 9-pent-4-ynyl-8-(2-trifluoromethoxy-phenylsulfanyl)-9<i>H</i>-purin-6-ylamine [ No CAS ]
  • 3-(pent-4-ynyl)-8-(2-(trifluoromethoxy)phenylthio)-3H-purin-6-amine [ No CAS ]
 

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