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Chemical Structure| 73834-77-2 Chemical Structure| 73834-77-2

Structure of 73834-77-2

Chemical Structure| 73834-77-2

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Product Details of [ 73834-77-2 ]

CAS No. :73834-77-2
Formula : C11H9N3
M.W : 183.21
SMILES Code : NC1=CC2=C(C=N1)NC3=C2C=CC=C3
MDL No. :MFCD00209818

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Application In Synthesis of [ 73834-77-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 73834-77-2 ]

[ 73834-77-2 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 73834-77-2 ]
  • [ 22651-87-2 ]
  • [ 1269418-57-6 ]
YieldReaction ConditionsOperation in experiment
83% General procedure: A solution of 11 (50 mg, 0.27 mmol) and carbxylic anhydride (0.54 mmol) in anhydrous pyridine (5 ml) was stirred at room temperature for 5 h. Saturated aqueous Na2CO3 solution was added and the mixture was stirred at room temperature for 1 h and extracted twice with ethyl acetate. The extracts were dried with anhydrous Na2SO4 and evaporated under reduced pressure. The residue was purified by flash chromatography on silica gel to afford (β-carbolin-3-yl)alkanecarboxamide (12b-e). To 12 in anhydrous THF (5 ml) was added LiAlH4 (25 mg, 0.66 mmol), and the mixture was refluxed for 2 h. A piece of ice (1 ml) was added, and the mixture was stirred at room temperature for 2 h and then filtered. The filtrate was concentrated in vacuo and the residue was purified by column chromatography on silica gel to afford the title compounds (1b-e).
  • 2
  • [ 73834-77-2 ]
  • [ 946-99-6 ]
  • C22H19N3O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
71% With potassium carbonate; potassium iodide; In acetonitrile; at 50℃; General procedure: To a solution of compound 4 (4.5mmol) in 50mL acetonitrile, was added 11 (8.2mmol), K2CO3 (6.0mmol), and KI (0.7mmol) at 50C for 8h. After the reaction completed, the reaction mixture was concentrated, and the residue was gathered through extraction and concentration, and further purified through quick column chromatography to yield compounds 12a-p. 5.2.1 Compound 12a Yield 71%, MS (ESI) m/z=358.2 [M+H]+. Analytical data for 12a: Yellow solid;1H NMR (DMSO-d6, 400MHz) delta 7.91 (t, 1H, Ar-H), 7.66 (d, J=7.4Hz, 4H, Ar-H), 7.61 (dd, J=16.0Hz,1H, CH=CH), 7.47-7.38 (m, 1H, Ar-H), 7.35 (d, J=8.2Hz, 1H, Ar-H), 7.10-6.99 (m, 2H, Ar-H), 6.59 (d, J=16.0Hz, 1H, CH=CH), 4.88 (s, 2H, CH2), 3.71 (s, 3H, -OCH3), 2.66 (m, 3H, CH3).
  • 3
  • [ 73834-77-2 ]
  • [ 946-99-6 ]
  • C21H18N4O2 [ No CAS ]
  • 4
  • [ 75792-33-5 ]
  • [ 73834-77-2 ]
  • N-(3-isopropoxybenzyl)-9H-pyrido[3,4-b]indol-3-amine [ No CAS ]
 

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