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Chemical Structure| 73833-13-3 Chemical Structure| 73833-13-3

Structure of 73833-13-3

Chemical Structure| 73833-13-3

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Product Details of [ 73833-13-3 ]

CAS No. :73833-13-3
Formula : C9H6ClNO5
M.W : 243.60
SMILES Code : O=C(OC)C1=CC=CC([N+]([O-])=O)=C1C(Cl)=O
MDL No. :MFCD30478655

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Application In Synthesis of [ 73833-13-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 73833-13-3 ]

[ 73833-13-3 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 73833-13-3 ]
  • [ 57113-90-3 ]
  • 2
  • [ 73833-13-3 ]
  • [ 139481-44-0 ]
  • 3
  • [ 73833-13-3 ]
  • [ 68-12-2 ]
  • [ 75-65-0 ]
  • [ 57113-90-3 ]
YieldReaction ConditionsOperation in experiment
Methyl-2-carboxy-3-nitro-benzoate (400 gm) was dissolved in toluene (1200 ml) and then added dimethylformamide (5 ml) at room temperature. The contents were heated to 75C and stirred for 30 minutes to obtain solution. Thionyl chloride (200 ml) was added to the solution and maintained for 2 hours at 75C. The reaction mass was distilled off the solvent completely under vacuum at below 50C to obtain residue. To the residue was added dimethylformamide (200 ml) and toluene (800 ml) at room temperature. A mixture of sodium azide (400 gm), dimethylformamide (900 ml) and Tetra-n-butylammonium bromide (40 gm) under stirring cooled to -10C was added to the above solution for 2 hours 30 minutes at -10C. The reaction mass maintained for 1 hour 30 minutes at -5C and then added water (2800 ml). The temperature of the reaction mass was raised to 10C and the layers were separated. The organic layer was dried over sodium sulfate and then added tert-butyl alcohol (1320 ml) under stirring. The temperature of the reaction mass was raised to 80 to 85C and maintained for 1 hour at 80 to 85C. The reaction mass was distilled off the solvent completely under vacuum at below 60C to obtain residue. To the residue was added diisopropyl ether (1000 ml) and stirred at reflux. The reaction mass cooled to room temperature and stirred for 4 hours and then cooled to 10C. The reaction mass stirred for 2 hours at 10C, filtered. The solid obtained was dried at 45 to 50C for 5 hours to obtain 400 gm of 2-tert-butoxy carbonylamino-3-nitro benzoic acid methyl ester.
  • 4
  • [ 13365-26-9 ]
  • [ 73833-13-3 ]
  • 5
  • [ 73833-13-3 ]
  • [ 150058-27-8 ]
 

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