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Chemical Structure| 73781-88-1 Chemical Structure| 73781-88-1

Structure of 73781-88-1

Chemical Structure| 73781-88-1

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Product Details of [ 73781-88-1 ]

CAS No. :73781-88-1
Formula : C8H10N2O2S
M.W : 198.24
SMILES Code : CCOC(=O)C1=CN=C(SC)N=C1
MDL No. :MFCD07779178
InChI Key :LVNRRUKCFUSBDL-UHFFFAOYSA-N
Pubchem ID :10442716

Safety of [ 73781-88-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 73781-88-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 73781-88-1 ]

[ 73781-88-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 73781-88-1 ]
  • [ 38324-83-3 ]
  • 2
  • [ 73781-88-1 ]
  • [ 19858-50-5 ]
  • [ 1108737-66-1 ]
  • 3
  • [ 23357-46-2 ]
  • [ 73781-88-1 ]
  • ethyl 2-[(1R)-1,2,3,4-tetrahydronaphthalen-1-ylamino]pyrimidin-5-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
84% 1. At 0 C,4.309 g (24.969 mmol) of m-chloroperoxybenzoic acid dissolved in 35 mL of chloroform was added dropwise to2.200 g (11.097 mmol) of 2- (methylthio) pyrimidine-5-carboxylic acid ethyl ester in 30 mL of chloroform.The mixture was stirred at 0-5 C for 0.5 hours,11.474 g (88.779 mmol) of N, N-diisopropylethylamine were added sequentiallyAnd 1.634 g (11.097 mmol) (1R) -1,2,3,4-tetrahydronaphthalen-1-amine dissolved in 10 mL of chloroform.The mixture was stirred at 40 C for 4 hours,Water and dichloromethane were added and the aqueous phase was extracted twice with dichloromethane.The combined organic phases were dried over sodium sulfate, then the solvent was removed under reduced pressure and the residue was dissolved in acetonitrile.The insoluble residue (3-chlorobenzoic acid) was filtered off, and then the solvent was removed under reduced pressure,There was obtained 2.763 g (84%) of 2-[(1R) -1,2,3,4-tetrahydronaphthalen-1-ylamino] pyrimidine-5-carboxylic acid ethyl ester,It was used in the next reaction without further purification.
 

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