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Chemical Structure| 7357-26-8 Chemical Structure| 7357-26-8

Structure of 7357-26-8

Chemical Structure| 7357-26-8

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Product Details of [ 7357-26-8 ]

CAS No. :7357-26-8
Formula : C10H9ClN2O2
M.W : 224.64
SMILES Code : COC1=CC2=NN=CC(Cl)=C2C=C1OC
MDL No. :MFCD14706388

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Application In Synthesis of [ 7357-26-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7357-26-8 ]

[ 7357-26-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 7357-26-8 ]
  • [ 904326-92-7 ]
  • [ 1119718-08-9 ]
YieldReaction ConditionsOperation in experiment
81% With tetrakis(triphenylphosphine) palladium(0); caesium carbonate; In 1,2-dimethoxyethane; water; at 90℃; 9 (74 mg, 0.33 mmol) was mixed with Pd(PPh3)4 (38 mg, 0.033 mmol) and 2-fluoro-3-methyl pyridine-5-boronic acid ( 62 mg, 0.4 mmol) in 1, 2 -dimethoxy-ethane (2 mL). A solution of cesium carbonate (271 mg, 0.83 mmol) in 2 mL water was added to the reaction mixture which was stirred overnight at 90 C. After the reaction was complete, the mixture was diluted with water (10mL) and extracted with ethyl acetate (3 × 15 mL). The combined organic layers were dried over anhydrous Na2SO4. The crude product was purified by flash chromatography using hexane/DCM/acetone (from 10/1/1, v/v/v) to yield 19 as a gray solid (80 mg, 81%).
 

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