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Chemical Structure| 73443-85-3 Chemical Structure| 73443-85-3

Structure of 73443-85-3

Chemical Structure| 73443-85-3

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Product Details of [ 73443-85-3 ]

CAS No. :73443-85-3
Formula : C7H4BrNOS
M.W : 230.08
SMILES Code : BrC1=C2NC(=O)SC2=CC=C1
MDL No. :MFCD07783780

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Application In Synthesis of [ 73443-85-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 73443-85-3 ]

[ 73443-85-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 885069-14-7 ]
  • [ 73443-85-3 ]
  • [ 1112980-19-4 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; at 85℃; for 11h; Example 98 (Method H); N-(6-(2-oxo-2,3-Dihydrobenzo [d] thiazol-4-yl)benzo [d] thiazol-2-yl)acetamide; Step 1 : 4-Bromobenzo[d]thiazol-2(3H)-one (69.9 mg, 0.304 mmol), N-(6-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)benzo[d]thiazol-2-yl)acetamide (124.9 mg, 3.925 mmol), dichlorobis(triphenyl- phosphine)palladium (II) (39.7 mg, 56.6 mumol), and sodium carbonate (0.30 mL, 2.0 M in water, 0.60 mmol) were suspended in 1 ,2-dimethoxyethane (1.4 mL) and ethanol (0.39 mL). The reaction flask was fit with a reflux condensor and the solution was heated in a preheated oil bath (85 C) and stirred under nitrogen for 7 hours, at which time the reaction was slowly allowed to cool to RT. After sitting at RT for 4 days, more PdCl2(PPh3)2 (37.3 mg) was added, and stirring was resumed at 85 C for 4 hours. Then, the reaction was cooled to RT and filtered through a silica gel plug with 10: 1 DCM / MeOH. The filtrate was concentrated and purified on HPLC (10-95% MeCN / water with 0.1% TFA over 40 minutes) to provide N-(6-(2-oxo-2,3-dihydrobenzo[d]thiazol-4-yl)benzo[d]thiazol-2-yl)acetamide. MS (ESI pos. ion) m/z: 342 (MH+). Calculated exact mass for C16HnN3O2S2: 341.
 

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