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Chemical Structure| 73289-83-5 Chemical Structure| 73289-83-5

Structure of 73289-83-5

Chemical Structure| 73289-83-5

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Product Details of [ 73289-83-5 ]

CAS No. :73289-83-5
Formula : C8H5NO2
M.W : 147.13
SMILES Code : O=CC1=CC=C(C#N)C(O)=C1
MDL No. :MFCD16999736

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Application In Synthesis of [ 73289-83-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 73289-83-5 ]

[ 73289-83-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 21962-49-2 ]
  • [ 73289-83-5 ]
YieldReaction ConditionsOperation in experiment
90% With pyridine hydrochloride; for 0.5h;Heating / reflux; 4-Formyl-2-hydroxybenzonitrile [0277] A mixture of nitrile (280 mg, 1, 737mmol) and pyridine hydrochloride (excess) was stirred and refluxed for 30 min. Water was added to the reaction mixture and extracted 3 times with ethyl acetate. The organic layer was washed 3 times with 10% HC1, dried, filtered and concentratrated to provide crude hydroxynitrile (230 mg, 90%). 1H RMN (400 MHz, acetone d6) 8 : 7.58 (d, 1H, J= 6. 2 Hz), 7.59 (d, 1H, J= 2.1 Hz), 7. 88 (dd, 1H, J= 2.1 and 6.2 Hz), 10. 07 (s, 1H), 10.4 (s, 1H).
 

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