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Chemical Structure| 726185-57-5 Chemical Structure| 726185-57-5

Structure of 726185-57-5

Chemical Structure| 726185-57-5

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Product Details of [ 726185-57-5 ]

CAS No. :726185-57-5
Formula : C5H7ClN2O2S
M.W : 194.64
SMILES Code : O=C(C1=CN=C(N)S1)OC.[H]Cl

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Application In Synthesis of [ 726185-57-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 726185-57-5 ]

[ 726185-57-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 726185-57-5 ]
  • [ 72605-86-8 ]
YieldReaction ConditionsOperation in experiment
34% 20 g of crushed ice were added to a suspension of 14.0 g (71.927 mmol) of methyl 2-aminothiazol-5-carboxylate hydrochloride in 8 ml of conc. hydrochloric acid and while cooling externally a solution of 5.0 g (72.464 mmol) of sodium nitrite in 30 ml of water was added dropwise, while the reaction temperature was kept below 0 C. at all times. After 30 minutes 7.2 g (72.735 mmol) of copper (I) chloride were added, the mixture was stirred for another hour while being cooled and in the following 1½ hours allowed to come slowly up to room temperature. The mixture was exhaustively extracted with diethyl ether, the combined extracts were washed with saturated saline solution, dried over sodium sulphate and evaporated down. 4.3 g (34% of theory) of a colourless oil were obtained, Rf=0.94 (EI D), which was used in the next steps without any further purification. [0524] MS: M+=177/179 (Cl)
 

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