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Chemical Structure| 7248-96-6 Chemical Structure| 7248-96-6

Structure of 7248-96-6

Chemical Structure| 7248-96-6

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Product Details of [ 7248-96-6 ]

CAS No. :7248-96-6
Formula : C6H8N2O3
M.W : 156.14
SMILES Code : O=C1NC(C(OCC)=CN1)=O

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Application In Synthesis of [ 7248-96-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7248-96-6 ]

[ 7248-96-6 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 7248-96-6 ]
  • [ 10025-87-3 ]
  • [ 280582-25-4 ]
  • 2
  • [ 7248-96-6 ]
  • [ 280582-25-4 ]
YieldReaction ConditionsOperation in experiment
25% Method 61 2,4-Dichloro-5-ethoxypyrimidine Using an analogous method to that described in Method 8, but starting from 5-ethoxyuracil (obtained by an analogous method to that described for the preparation of 5-methoxyuracil in J. Chem. Soc., 1960, 4590), the product was obtained in 25% yield. NMR (CDCl3): 1.45 (t, 3H), 4.15 (q, 2H), 8.1 (s, 1H).
  • 3
  • [ 7248-96-6 ]
  • [ 280582-25-4 ]
YieldReaction ConditionsOperation in experiment
35.57% With N,N-dimethyl-aniline; trichlorophosphate;Reflux; 2,4-Dichloro-5-ethoxy-pyrimidine[0095] In ice bath, dimethyl-phenyl-amine (5.21ml, 1.0 eq) was added dropwise to slurry of 5-ethoxy-pyrimidine-2,4-diol (6.45 g, 1.0 eq) in POCl3 (20 ml, 5.0 eq) and refluxed overnight. Excess POCl3 was evaporated in vacuo and the residue was poured into ice-water. After formation of precipitates, the mixture was filtered and dried solid in vacuo. A product was obtained as a white solid (2.84 g, 35.57%)1H NMR (500 MHz, CDCl3-di): 51.47-1.50(m, 3H), 4.16-4.20(m, 2H), 8.13(s, 1H)
 

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