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Chemical Structure| 7238-62-2 Chemical Structure| 7238-62-2

Structure of 7238-62-2

Chemical Structure| 7238-62-2

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Product Details of [ 7238-62-2 ]

CAS No. :7238-62-2
Formula : C7H8ClNO2S
M.W : 205.66
SMILES Code : O=C(C1=C(C)N=C(Cl)S1)OCC
MDL No. :MFCD02956798
InChI Key :VUARUZUFHDNJSY-UHFFFAOYSA-N
Pubchem ID :594903

Safety of [ 7238-62-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 7238-62-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7238-62-2 ]

[ 7238-62-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 7311-95-7 ]
  • [ 7238-62-2 ]
  • [ 122945-79-3 ]
  • 2
  • [ 540-80-7 ]
  • [ 7210-76-6 ]
  • [ 7238-62-2 ]
YieldReaction ConditionsOperation in experiment
94% With hydrogenchloride;copper(I) chloride; In water; acetonitrile; B. Ethyl 2-chloro-4-methyl-5-thiazolecarboxylate To a mixture of t-butyl nitrite (8.30 g, 80 mmol), cuprous chloride (6.38 g, 65 mmol) in 400 mL of acetonitrile was added Ethyl 2-Amino-4-methyl-5-thiazole-carboxylate (10 g, 54 mmol) in one portion. The thiazole dissolved after 25 minutes, and the reaction was allowed to stir at room temperature for 2 hours. The temperature was then increased to 66 C. for one hour. The solution was gradually allowed to cool to room temperature and filtered. The filtrate was poured into 400 mL of 6N HCl (the solution began fizzing). The solution was strirred for 20 minutes at which time TLC analysis showed that all of the starting material had been consumed and one product formed. The aqueous mixture was diluted with 700 mL of H2O and then extracted with ethyl acetate (4*400 mL). The ethyl acetate fractions were dried over anhydrous MgSO4, filtered and concentrated in vacuo to give 10.45 g (94% yield) of a reddish oil which crystallized to a reddish-orange solid: 1H NMR (CDCl3) δ4.35 (q, 2H), 2.7 (s, 3H), 1.35 (t, 3H).
  • 3
  • [ 540-80-7 ]
  • [ 7210-76-6 ]
  • [ 7732-18-5 ]
  • [ 7238-62-2 ]
YieldReaction ConditionsOperation in experiment
94% With hydrogenchloride;copper(I) chloride; In acetonitrile; B. Ethyl 2-chloro-4-methyl-5-thiazolecarboxylate To a mixture of t-butyl nitrite (8.30 g, 80 mmol), cuprous chloride (6.38 g, 65 mmol) in 400 mL of acetonitrile was added Ethyl 2-Amino-4-methyl-5-thiazole-carboxylate (10 g, 54 mmol) in one portion. The thiazole dissolved after 25 minutes, and the reaction was allowed to stir at room temperature for 2 hours. The temperature was then increased to 66 C. for one hour. The solution was gradually allowed to cool to room temperature and filtered. The filtrate was poured into 400 mL of 6N HCl (the solution began fizzing). The solution was strirred for 20 minutes at which time TLC analysis showed that all of the starting material had been consumed and one product formed. The aqueous mixture was diluted with 700 mL of H2 O and then extracted with ethyl acetate (4*400 mL). The ethyl acetate fractions were dried over anhydrous MgSO4, filtered and concentrated in vacuo to give 10.45 g (94% yield) of a reddish oil which crystallized to a reddish-orange solid: 1 H NMR (CDCl3) 67 4.35 (q, 2H), 2.7 (s, 3H), 1.35 (t, 3H).
 

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