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Chemical Structure| 716358-46-2 Chemical Structure| 716358-46-2

Structure of 716358-46-2

Chemical Structure| 716358-46-2

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Product Details of [ 716358-46-2 ]

CAS No. :716358-46-2
Formula : C10H13NO4S
M.W : 243.28
SMILES Code : O=C(O)C1=CC=CC(S(=O)(NC(C)C)=O)=C1
MDL No. :MFCD05270857

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 716358-46-2 ]

[ 716358-46-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 716358-46-2 ]
  • [ 1840-27-3 ]
  • [ 1572513-34-8 ]
YieldReaction ConditionsOperation in experiment
216 mg With N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; at 20℃;Inert atmosphere; Compound 186 3-(isopropylsulfamoyl)benzoic acid (250 mg, 1.03 mmol), 4-fluoro-3,5-dimethyl- aniline (157 mg, 1.13 mmol) and DIPEA (398 mg, 3.08 mmol) were mixed in acetonitrile (10 mL) at room temperature under a nitrogen atmosphere. HATU (430 mg, 1.13 mmol) was added and the mixture was stirred overnight. EtOAc (100 mL) was added and the mixture was washed with 1M HC1, sat NaHC03 and brine. After drying over MgS04 and evaporation to dryness in vacuo, the obtained residue was crystallized from MeOH (10 mL) to provide a white solid (216 mg). Method F; Rt: 1.04 min. m/z: 382.2 (M+NH4)+ Exact mass: 364.1. 1 H NMR (400 MHz, DMSO-d6) δ ppm 0.96 (d, J=6.6 Hz, 6 H), 2.23 (d, J=2.0 Hz, 6 H), 3.23 - 3.29 (m, 1 H), 7.48 (d, J=6.6 Hz, 2 H), 7.66 - 7.80 (m, 2 H), 7.95 - 8.04 (m, 1 H), 8.18 (d, J=7.9 Hz, 1 H), 8.35 (t, J=1.7 Hz, 1 H), 10.37 (s, 1 H).
 

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