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Chemical Structure| 713-67-7 Chemical Structure| 713-67-7
Chemical Structure| 713-67-7
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Product Details of [ 713-67-7 ]

CAS No. :713-67-7
Formula : C9H7F3OS
M.W : 220.21
SMILES Code : CC(C1=CC=C(SC(F)(F)F)C=C1)=O
MDL No. :MFCD00236332

Safety of [ 713-67-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 713-67-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 713-67-7 ]

[ 713-67-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 713-67-7 ]
  • [ 92914-74-4 ]
  • [ 1242515-23-6 ]
YieldReaction ConditionsOperation in experiment
48% With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 - 60℃; Synthesis of exemplary compound 5: N-(1-(4-(Trifluoromethylthio)phenyl)-ethyp<strong>[92914-74-4]isoxazolo[5,4-b]pyridin-3-amine</strong> 484 mg (2.2 mmol) of 4'-(trifluoromethylthio)acetophenone were added to a solution of 270 mg (2.0 mmol) of <strong>[92914-74-4]isoxazolo[5,4-b]pyridin-3-amine</strong> (intermediate VX001) in DCM (20 ml), and the mixture was stirred for 1 h at RT. 958 mul (6.0 mmol) of triethylsilane and 446 mul (6.0 mmol) of TFA were then added, and the reaction solution was stirred for 7 d at 60 C. After cooling to RT, the mixture was rendered basic with a sat. aq. NaHCO3 soln. The phases were separated, and the aqueous phase was again extracted with DCM. The combined organic phases were dried over Na2SO4, filtered and concentrated in vacuo. CC (EA/hexane 1:1) of the residue yielded 328 mg (1.0 mmol, 48%) of N-(1-(4-(trifluoromethylthio)phenyl)ethyl)-<strong>[92914-74-4]isoxazolo[5,4-b]pyridin-3-amine</strong>. MS: m/z 340.1 [M+H]+.
 

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