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A solution of sodium methoxide in methanol (2.17M-2.76 ml; 6 mmol) was added to a suspension of the urea (Intermediate 29, 700 mg; 2 mmol) in methanol (10 ml) at 23. The mixture was stirred under nitrogen for 1.5 h then poured into 15% phosphate buffer solution (200 ml) and extracted with chloroform (3*100 ml) and ethyl acetate (100 ml). The combined, dried extracts were evaporated and the residue triturated with ethyl acetate to give the triazinedione (305 mg; 48%) as a cream solid with m.p. >250.
d. 4-Dimethylamino-1-ethyl-1,3,5-triazine-2,6-dione. The triazinone from (c) (0.5 g) was heated in an oil bath at 220 C for 10 minutes. The cooled product was recrystallized from ethanol to give the triazine-dione having a melting point of 233-235 C (decomp.).
Among the compounds of formula (II), mention may be made especially of the following preferred compounds: parabanic acid ... 1-methyluracil 3-methyluracil 5-methyluracil 1,3-dimethyluracil 5-azauracil 6-azauracil 5-fluorouracil 6-fluorouracil ...
10
silver-salt of/the/ 4,6-dioxo-1,4,5,6-tetrahydro-<1,3,5>triazine-2-carboxylic acid[ No CAS ]