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Chemical Structure| 705250-77-7 Chemical Structure| 705250-77-7

Structure of 705250-77-7

Chemical Structure| 705250-77-7

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Product Details of [ 705250-77-7 ]

CAS No. :705250-77-7
Formula : C12H8F6O2
M.W : 298.18
SMILES Code : COC(/C=C/C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O
MDL No. :MFCD01861885

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Application In Synthesis of [ 705250-77-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 705250-77-7 ]

[ 705250-77-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 328-72-3 ]
  • [ 32673-25-9 ]
  • [ 19293-63-1 ]
  • [ 292638-85-8 ]
  • [ 705250-77-7 ]
YieldReaction ConditionsOperation in experiment
With NBu4Br;palladium diacetate; In ISOPROPYLAMIDE; water; Example 13 Synthesis of Methyl 3,5-bis(trifluoromethyl)cinnamate 0.619 g (7.2 mmol) of methyl acrylate, 38.7 mg (120 mumol) of NBu4Br, 6.7 mg (30 mumol) of palladium acetate and 26.7 mg (120 mumol) of phenyldi(t-butyl)phosphine are weighed into a Schlenk vessel. 1.49 g (6 mmol) of <strong>[328-72-3]3,5-bis(trifluoromethyl)chlorobenzene</strong> and 1.53 ml (7.2 mmol) of dicyclohexylmethylamine and also 3.5 ml of dimethylacetamide are then added. The Schlenk vessel is placed in a heating bath at 130 C. and the contents are stirred. After 4 hours, the contents are poured into 30 ml of water and the product is extracted by shaking with t-butyl methyl ether. After drying the organic phase over MgSO4, the solvent is removed under reduced pressure and the product is isolated. Yellowish, crystalline solid, yield: 1.34 g (97% of theory).
 

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