70395-35-6|Sodium chlorofluoroacetate| Ambeed

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Quality Control of [ 70395-35-6 ] Purity: 98% SDS Specification

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Product Details of [ 70395-35-6 ]

CAS No. :	70395-35-6
Formula :	C₂HClFNaO₂
M.W :	134.47
SMILES Code :	O=C([O-])C(Cl)F.[Na+]
MDL No. :	MFCD01861160
Boiling Point :	No data available
InChI Key :	CETNZZYKKVKEFX-UHFFFAOYSA-M
Pubchem ID :	2782421

Safety of [ 70395-35-6 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 70395-35-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 70395-35-6 ]

[ 70395-35-6 ] Synthesis Path-Downstream 1~35

1
[ 96290-79-8 ]
[ 70395-35-6 ]

Yield	Reaction Conditions	Operation in experiment
504 g (94%)	With sodium hydroxide;	A. Sodium Chlorofluoroacetate STR24 Eight hundred ml (4 mole) of 5 N sodium hydroxide was added dropwise over a period of 30 min. to a stirred sample of 523.8 g (4.0 mole) of ethyl chlorofluoroacetate (prepared as described by B. Englund, "Organic Syntheses," Col. Vol. IV, p. 184, John Wiley and Sons, Inc., New York, 1963) contained in a 1-liter flask cooled in an ice bath. Stirring was continued until a homogenous solution was obtained (about 30 min.), and then the resulting solution was evaporated to dryness at 100 and under reduced pressure. The white residue was broken up and dried in a vacuum oven at 80 to give 504 g (94%) of sodium chlorofluoroacetate as a white crystalline powder.
504 g (94%)	With sodium hydroxide;	Part A. Sodium Chlorofluoroacetate STR11 Eight hundred ml (4 mole) of 5N sodium hydroxide was added dropwise over a period of 30 min. to a stirred sample of 523.8 g (4.0 mole) of ethyl chlorofluoroacetate (prepared as described by B. Englund, "Organic Syntheses," Col. Vol. IV, p. 184, John Wiley and Sons, Inc., New York, 1963) contained in a 1-liter flask cooled in an ice bath. Stirring was continued until a homogenous solution was obtained (about 30 min.), and then the resulting solution was evaporated to dryness at 100 and under reduced pressure. The white residue was broken up and dried in a vacuum oven at 80 to give 504 g (94%) of sodium chlorofluoroacetate as a white crystalline powder.

References: [1]Patent: US4182760,1980,A .
[2]Patent: US4141895,1979,A .

2
[ 70395-35-6 ]
[ 359-32-0 ]

Yield	Reaction Conditions	Operation in experiment
		Part B. Chlorofluoroacetyl Chloride STR25 A 3-l., three-necked flask was fitted with a thermometer, a heating mantle, a mechanical stirrer, and a distillation head with a condenser and a 500 ml receiving flask backed up by a dry ice cooled trap. The reaction flask was charged with 500 g (3.72 mole) of crude <strong>[70395-35-6]sodium chlorofluoroacetate</strong> and 1 l. (1400 g. 6.9 mole) of practical grade phthaloyl chloride. The stirrer was started, and the contents of the flask were heated slowly until product began to distill from the reaction mixture (pot temperature about 100-110). The heating mantle was turned off until the initial reaction subsided, and then heating was resumed and continued until the pot temperature reached 245. The distillate in the receiver and the dry ice cooled trap were combined (437 g. 90% crude yield) and redistilled through an 18 in. spinning band column to give 330.8 g (68%) of chlorofluoroacetyl chloride as a colorless liquid, bp 69-69.5. The fraction boiling between 65 and 69 was redistilled to give an additional 45.3 g (9.3%), which is a total yield of 376.1 g (77%) of product boiling at 69-69.5.
		Part B. Chlorofluoroacetyl Chloride STR12 A 3-l., three-necked flask was fitted with a thermometer, a heating mantle, a mechanical stirrer, and a distillation head with a condenser and a 500 ml receiving flask backed up by a dry ice cooled trap. The reaction flask was charged with 500 g (3.72 mole) of crude <strong>[70395-35-6]sodium chlorofluoroacetate</strong> and 1 l. (1400 g, 6.9 mole) of practical grade phthaloyl chloride. The stirrer was started, and the contents of the flask were heated slowly until product began to distill from the reaction mixture (pot temperature about 100-110). The heating mantle was turned off until the initial reaction subsided, and then heating was resumed and continued until the pot temperature reached 245. The distillate in the receiver and the dry ice cooled trap were combined (437 g, 90% crude yield) and redistilled through an 18 in. spinning band column to give 330.8 g (68%) of chlorofluoroacetyl chloride as a colorless liquid, bp 69-69.5. The fraction boiling between 65 and 69 was redistilled to give an additional 45.3 g (9.3%), which is a total yield of 376.1 g (77%) of product boiling at 69-69.5.

References: [1]Patent: US4182760,1980,A .
[2]Patent: US4141895,1979,A .

3
[ 58101-60-3 ]
[ 70395-35-6 ]
[ 1093750-99-2 ]