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Chemical Structure| 7035-03-2 Chemical Structure| 7035-03-2

Structure of 7035-03-2

Chemical Structure| 7035-03-2

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Product Details of [ 7035-03-2 ]

CAS No. :7035-03-2
Formula : C9H9NO
M.W : 147.17
SMILES Code : N#CCC1=CC=CC=C1OC
MDL No. :MFCD00001902
InChI Key :DWJKILXTMUGXOU-UHFFFAOYSA-N
Pubchem ID :81496

Safety of [ 7035-03-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302+H312+H332-H315-H319
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501

Application In Synthesis of [ 7035-03-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 7035-03-2 ]
  • Downstream synthetic route of [ 7035-03-2 ]

[ 7035-03-2 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 7035-03-2 ]
  • [ 7062-40-0 ]
YieldReaction ConditionsOperation in experiment
96% With N-Bromosuccinimide; iodine In acetonitrile for 12 h; Darkness General procedure: To a reaction tube charged with NBS (1.5 equiv, 0.3 mmol), catalyst (10 molpercent, 0.02 mmol) and CH3CN (1.0 mL),was added para-chloroanisole 1a (0.2 mmol). After being stirred at room temperature for 12 h in dark, the reaction was quenched by saturated aq. solution of Na2S2O3 (2 mL). The resulting mixture was extracted by ethyl acetate (3 5 mL). The combined organic extracts were washed by brine (10 mL), dried over Na2SO4 and filtered through a pad of Celite. The filtrate was concentrated under reduced pressure and the residuewas purified by flash chromatography on a silica gel column with petroleum ether/dichloromethane (5:1) as the eluent to give 4.3.1. 2-Bromo-4-chloroanisole (2a)
References: [1] Tetrahedron, 2017, vol. 73, # 50, p. 7105 - 7114.
 

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