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Chemical Structure| 70291-67-7 Chemical Structure| 70291-67-7

Structure of 70291-67-7

Chemical Structure| 70291-67-7

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Product Details of [ 70291-67-7 ]

CAS No. :70291-67-7
Formula : C10H12ClNO
M.W : 197.66
SMILES Code : ClC1=CC=C(N2CCOCC2)C=C1
MDL No. :MFCD09038510
InChI Key :KDWPYZPZUPWJGB-UHFFFAOYSA-N
Pubchem ID :10420251

Safety of [ 70291-67-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H311-H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P337+P313-P305+P351+P338-P332+P313-P362-P301+P312+P330-P302+P352+P312-P405
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 70291-67-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 70291-67-7 ]

[ 70291-67-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 70291-67-7 ]
  • [ 73183-34-3 ]
  • [ 568577-88-8 ]
YieldReaction ConditionsOperation in experiment
86% With (2,2,2-trifluoroethoxy)trimethylsilane; cesium fluoride; dichlorobis(trimethylphosphine)nickel; In tetrahydrofuran; at 100℃; for 12h;Inert atmosphere; Sealed tube; Under an argon atmosphere,4.2 mg (0.015 mmol) of dichlorobis (trimethylphosphine) nickel,98.4 mg (0.5 mmol) of 4- (4-chlorophenyl) morpholine,152 mg (1.0 mmol) of cesium fluoride, 4,4,5,5,4 ', 4', 5 ', 5'-octamethyl-2,2'-bi (1,3,2-dioxaborolanyl ) 140 mg (0.55 mmol),180 mg (1.05 mmol) of trimethyl (2,2,2-trifluoroethoxy) silane and 0.5 mL of tetrahydrofuran were added and sealed,And the mixture was stirred at 100 C. for 12 hours.After the reaction vessel was cooled to room temperature, 1 mL of a saturated aqueous solution of ammonium chloride was added, and the mixture was extracted three times with 8 mL of ethyl acetate, and the obtained organic phases were combined.The solvent was distilled off under reduced pressure, and the residue was purified using silica gel column chromatography (hexane: chloroform: ethyl acetate = 4: 1: 0 to 4: 1: 1)123 mg (white solid, yield 86%) of 4- [4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) phenyl] morpholine was obtained
 

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