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Chemical Structure| 70264-94-7 Chemical Structure| 70264-94-7

Structure of 70264-94-7

Chemical Structure| 70264-94-7

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Product Details of [ 70264-94-7 ]

CAS No. :70264-94-7
Formula : C10H11BrO3
M.W : 259.10
SMILES Code : O=C(OC)C1=CC=C(CBr)C(OC)=C1
MDL No. :MFCD00270115
InChI Key :UXSNXOMMJXTFEG-UHFFFAOYSA-N
Pubchem ID :2759828

Safety of [ 70264-94-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H317-H318-H410
Precautionary Statements:P261-P264-P272-P273-P280-P302+P352-P305+P351+P338+P310-P333+P313-P391-P501
Class:9
UN#:3077
Packing Group:

Application In Synthesis of [ 70264-94-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 70264-94-7 ]

[ 70264-94-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 453-71-4 ]
  • [ 70264-94-7 ]
  • [ 118-92-3 ]
  • [ 175204-45-2 ]
  • 4-[8-Carbamoyl-10-(2,6-dichloro-pyridin-4-ylmethyl)-11-oxo-10,11-dihydro-dibenzo[b,e][1,4]diazepin-5-ylmethyl]-3-methoxy-benzoic acid methyl ester [ No CAS ]
  • 2
  • [ 72287-26-4 ]
  • 7-(cyclopentylacetamido)naphth-1-yl triflate [ No CAS ]
  • [ 70264-94-7 ]
  • methyl 4-[7-(cyclopentylacetamido)naphth-1-ylmethyl]-3-methoxybenzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
79% With zinc; In tetrahydrofuran; ethyl acetate; f. Methyl 4-[7-(cyclopentylacetamido)naphth-1-ylmethyl]-3-methoxybenzoate A mixture of activated zinc dust (806 mg), methyl 4-bromomethyl-3-methoxybenzoate (2.14 g) and tetrahydrofuran (15 ml) was stirred for 18 h. To the reaction was added dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) (76 mg). After stirring for 15 min, 7-(cyclopentylacetamido)naphth-1-yl triflate (830 mg) in tetrahydrofuran (10 ml) was added and the mixture was stirred for 72 h. The mixture was added to 100 ml of ethyl acetate and the ethyl acetate solution was washed (1N HCl, brine), dried (MgSO4) and evaporated. The residue was flash chromatographed, eluding with ether:petroleum ether (2:8,4:6, and 1:4, successively), to give a white solid. Recrystallization from methylene chloride and petroleum ether gave the title compound as a colorless solid (705 mg, 79percent); mp 172.5°-174.5° C. Analysis for C27 H29 NO4: Calculated: C, 75.15; H, 6.77; N, 3.24. Found: C, 74.82; H, 6.78; N, 2.85.
 

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