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Chemical Structure| 69922-27-6 Chemical Structure| 69922-27-6

Structure of 69922-27-6

Chemical Structure| 69922-27-6

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Product Details of [ 69922-27-6 ]

CAS No. :69922-27-6
Formula : C8H3F4NO
M.W : 205.11
SMILES Code : FC(C1=CC=C(F)C(N=C=O)=C1)(F)F
MDL No. :MFCD00673069
InChI Key :NAIKHCBDZGSGHH-UHFFFAOYSA-N
Pubchem ID :2733380

Safety of [ 69922-27-6 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H226-H301-H315-H319-H330-H334-H335
Precautionary Statements:P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P284-P285-P301+P310-P302+P352-P303+P361+P353-P304-P304+P340-P304+P341-P305+P351+P338-P310-P312-P320-P321-P330-P332+P313-P337+P313-P340-P342+P311-P362-P370+P378-P403-P403+P233-P403+P235-P405-P501
Class:6.1(3)
UN#:3080
Packing Group:

Application In Synthesis of [ 69922-27-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 69922-27-6 ]

[ 69922-27-6 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 180995-12-4 ]
  • [ 69922-27-6 ]
  • [ 214360-73-3 ]
  • N-[4-(3-amino-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea [ No CAS ]
  • N-[4-(3-amino-1H-pyrazolo[4,3-c]pyridin-4-yl)phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea [ No CAS ]
  • 2
  • [ 1003-61-8 ]
  • [ 69922-27-6 ]
  • [ 924668-30-4 ]
YieldReaction ConditionsOperation in experiment
In N,N-dimethyl-formamide; at 70℃; for 1h; EXAMPLE 4; 6-{2-[3-(2-Fluoro-5-trifluoromethyl phenyl)ureido]thiazol-5-yl}-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (2-morpholin-4-ylethyl)amide trifluoroacetate The product of example 4 can be prepared by the process described above in scheme 4:Synthesis of Intermediate 1:2-Fluoro-(5-trifluoromethyl)phenylisocyanate (4 g, 19.5 mmol) is added to a solution of <strong>[1003-61-8]2-aminothiazole-5-carboxaldehyde</strong> (2.5 g, 19.5 mmol) in DMF (120 ml). The solution is heated at 70 C. for 1 h, evaporated, and purified by chromatography on silica gel, eluting with 1:1 hexane/EtOAc. The fractions containing intermediate 1 are combined and evaporated so as to provide intermediate 1 in the form of a yellow solid (4.28 g).
  • 3
  • [ 18542-98-8 ]
  • [ 69922-27-6 ]
 

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