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Chemical Structure| 694499-26-8 Chemical Structure| 694499-26-8

Structure of AP24592
CAS No.: 694499-26-8

Chemical Structure| 694499-26-8

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Dilday, Tinslee ; Abt, Melissa ; Ramos-Solis, Nicole ; Dayal, Neetu ; Larocque, Elizabeth ; Oblak, Adrian L. , et al.

Abstract: Human epidermal growth factor receptor 2 (HER2)-targeted agents have proven to be effective, however, the development of resistance to these agents has become an obstacle in treating HER2+ breast cancer. Evidence implicates HUNK as an anti-cancer target for primary and resistant HER2+ breast cancers. In this study, a selective inhibitor of HUNK is characterized alongside a phosphorylation event in a downstream substrate of HUNK as a marker for HUNK activity in HER2+ breast cancer. Rubicon has been established as a substrate of HUNK that is phosphorylated at (S) 92. Findings indicate that HUNK-mediated phosphorylation of Rubicon at S92 promotes both and tumorigenesis in HER2/neu+ breast cancer. HUNK inhibition prevents Rubicon S92 phosphorylation in HER2/neu+ breast cancer models and inhibits tumorigenesis. This study characterizes a downstream phosphorylation event as a measure of HUNK activity and identifies a selective HUNK inhibitor that has meaningful efficacy toward HER2+ breast cancer.

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Product Details of [ AP24592 ]

CAS No. :694499-26-8
Formula : C13H18F3N3
M.W : 273.30
SMILES Code : NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1
MDL No. :MFCD09909924
InChI Key :ZMWAZMYBMAAMAW-UHFFFAOYSA-N
Pubchem ID :46838908

Safety of [ AP24592 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P280-P305+P351+P338-P310

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