Home Cart Sign in  
Chemical Structure| 69-93-2 Chemical Structure| 69-93-2
Chemical Structure| 69-93-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Uric acid activates NFκB in a variety of cell culture models including proximal tubular cells. Uric acid suppresses 1-α hydroxylase mRNA and protein expression in dose dependent and time dependent manner.

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations

Brandt, Tiffany J ; Skaggs, Hayden ; Hundley, Thomas ; Yoder-Himes, Deborah R ;

Abstract: Staphylococcus aureus asymptomatically colonizes the nasal cavity and pharynx of up to 60% of the human population and, as an opportunistic pathogen, can breach its normal habitat, resulting in life-threatening infections. S. aureus infections are of additional concern for populations with impaired immune function such as those with cystic fibrosis (CF) or chronic granulomatous disease. Multi-drug resistance is increasingly common in S. aureus infections, creating an urgent need for new antimicrobials or compounds that improve efficacy of currently available antibiotics. S. aureus biofilms, such as those found in the lungs of people with CF and in soft tissue infections, are notoriously recalcitrant to antimicrobial treatment due to the characteristic metabolic differences associated with a sessile mode of growth. In this work, we show that another CF pathogen, Burkholderia cenocepacia, produces one or more secreted compounds that can prevent S. aureus biofilm formation and inhibit existing S. aureus biofilms. The B. cenocepacia-mediated antagonistic activity is restricted to S. aureus species and perhaps some other staphylococci; however, this inhibition does not necessarily extend to other Gram-positive species. This inhibitory activity is due to death of S. aureus through a contact-independent mechanism, potentially mediated through the siderophore pyochelin and perhaps additional compounds. This works paves the way to better understanding of interactions between these two bacterial pathogens.

Keywords: Burkholderia cenocepacia ; Staphylococcus aureus ; biofilm ; inhibition

Purchased from AmBeed: ; ; ; ;

Alternative Products

Product Details of Uric acid

CAS No. :69-93-2
Formula : C5H4N4O3
M.W : 168.11
SMILES Code : O=C(NC(N1)=C2NC1=O)NC2=O
MDL No. :MFCD00005712
InChI Key :LEHOTFFKMJEONL-UHFFFAOYSA-N
Pubchem ID :1175

Safety of Uric acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of Uric acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 69-93-2 ]

[ 69-93-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 69-93-2 ]
  • [ 7664-41-7 ]
  • [ 7697-37-2 ]
  • [ 61066-33-9 ]
  • [ 3051-09-0 ]
  • 2
  • [ 1004-38-2 ]
  • [ 69-93-2 ]
  • C4H7N5*C5H4N4O3 [ No CAS ]
 

Historical Records

Categories