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Chemical Structure| 67984-81-0 Chemical Structure| 67984-81-0

Structure of 67984-81-0

Chemical Structure| 67984-81-0

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Product Details of [ 67984-81-0 ]

CAS No. :67984-81-0
Formula : C7H5NO2
M.W : 135.12
SMILES Code : N#CC1=CC=CC(O)=C1O
MDL No. :MFCD02261930
InChI Key :XHPDHXXZBWDFIB-UHFFFAOYSA-N
Pubchem ID :3017820

Safety of [ 67984-81-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P280-P305+P351+P338-P310

Computational Chemistry of [ 67984-81-0 ] Show Less

Physicochemical Properties

Num. heavy atoms 10
Num. arom. heavy atoms 6
Fraction Csp3 0.0
Num. rotatable bonds 0
Num. H-bond acceptors 3.0
Num. H-bond donors 2.0
Molar Refractivity 35.2
TPSA ?

Topological Polar Surface Area: Calculated from
Ertl P. et al. 2000 J. Med. Chem.

64.25 Ų

Lipophilicity

Log Po/w (iLOGP)?

iLOGP: in-house physics-based method implemented from
Daina A et al. 2014 J. Chem. Inf. Model.

0.98
Log Po/w (XLOGP3)?

XLOGP3: Atomistic and knowledge-based method calculated by
XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry

1.25
Log Po/w (WLOGP)?

WLOGP: Atomistic method implemented from
Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.

0.97
Log Po/w (MLOGP)?

MLOGP: Topological method implemented from
Moriguchi I. et al. 1992 Chem. Pharm. Bull.
Moriguchi I. et al. 1994 Chem. Pharm. Bull.
Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.

0.18
Log Po/w (SILICOS-IT)?

SILICOS-IT: Hybrid fragmental/topological method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

0.84
Consensus Log Po/w?

Consensus Log Po/w: Average of all five predictions

0.84

Water Solubility

Log S (ESOL):?

ESOL: Topological method implemented from
Delaney JS. 2004 J. Chem. Inf. Model.

-1.91
Solubility 1.67 mg/ml ; 0.0123 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Very soluble
Log S (Ali)?

Ali: Topological method implemented from
Ali J. et al. 2012 J. Chem. Inf. Model.

-2.2
Solubility 0.857 mg/ml ; 0.00634 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble
Log S (SILICOS-IT)?

SILICOS-IT: Fragmental method calculated by
FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com

-1.3
Solubility 6.76 mg/ml ; 0.05 mol/l
Class?

Solubility class: Log S scale
Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly

Soluble

Pharmacokinetics

GI absorption?

Gatrointestinal absorption: according to the white of the BOILED-Egg

High
BBB permeant?

BBB permeation: according to the yolk of the BOILED-Egg

Yes
P-gp substrate?

P-glycoprotein substrate: SVM model built on 1033 molecules (training set)
and tested on 415 molecules (test set)
10-fold CV: ACC=0.72 / AUC=0.77
External: ACC=0.88 / AUC=0.94

No
CYP1A2 inhibitor?

Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.83 / AUC=0.90
External: ACC=0.84 / AUC=0.91

No
CYP2C19 inhibitor?

Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set)
and tested on 3000 molecules (test set)
10-fold CV: ACC=0.80 / AUC=0.86
External: ACC=0.80 / AUC=0.87

No
CYP2C9 inhibitor?

Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set)
and tested on 2075 molecules (test set)
10-fold CV: ACC=0.78 / AUC=0.85
External: ACC=0.71 / AUC=0.81

No
CYP2D6 inhibitor?

Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set)
and tested on 1068 molecules (test set)
10-fold CV: ACC=0.79 / AUC=0.85
External: ACC=0.81 / AUC=0.87

No
CYP3A4 inhibitor?

Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set)
and tested on 2579 molecules (test set)
10-fold CV: ACC=0.77 / AUC=0.85
External: ACC=0.78 / AUC=0.86

Yes
Log Kp (skin permeation)?

Skin permeation: QSPR model implemented from
Potts RO and Guy RH. 1992 Pharm. Res.

-6.24 cm/s

Druglikeness

Lipinski?

Lipinski (Pfizer) filter: implemented from
Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev.
MW ≤ 500
MLOGP ≤ 4.15
N or O ≤ 10
NH or OH ≤ 5

0.0
Ghose?

Ghose filter: implemented from
Ghose AK. et al. 1999 J. Comb. Chem.
160 ≤ MW ≤ 480
-0.4 ≤ WLOGP ≤ 5.6
40 ≤ MR ≤ 130
20 ≤ atoms ≤ 70

None
Veber?

Veber (GSK) filter: implemented from
Veber DF. et al. 2002 J. Med. Chem.
Rotatable bonds ≤ 10
TPSA ≤ 140

0.0
Egan?

Egan (Pharmacia) filter: implemented from
Egan WJ. et al. 2000 J. Med. Chem.
WLOGP ≤ 5.88
TPSA ≤ 131.6

0.0
Muegge?

Muegge (Bayer) filter: implemented from
Muegge I. et al. 2001 J. Med. Chem.
200 ≤ MW ≤ 600
-2 ≤ XLOGP ≤ 5
TPSA ≤ 150
Num. rings ≤ 7
Num. carbon > 4
Num. heteroatoms > 1
Num. rotatable bonds ≤ 15
H-bond acc. ≤ 10
H-bond don. ≤ 5

1.0
Bioavailability Score?

Abbott Bioavailability Score: Probability of F > 10% in rat
implemented from
Martin YC. 2005 J. Med. Chem.

0.55

Medicinal Chemistry

PAINS?

Pan Assay Interference Structures: implemented from
Baell JB. & Holloway GA. 2010 J. Med. Chem.

1.0 alert
Brenk?

Structural Alert: implemented from
Brenk R. et al. 2008 ChemMedChem

1.0 alert: heavy_metal
Leadlikeness?

Leadlikeness: implemented from
Teague SJ. 1999 Angew. Chem. Int. Ed.
250 ≤ MW ≤ 350
XLOGP ≤ 3.5
Num. rotatable bonds ≤ 7

No; 1 violation:MW<1.0
Synthetic accessibility?

Synthetic accessibility score: from 1 (very easy) to 10 (very difficult)
based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties,
trained on 12'782'590 molecules and tested on 40 external molecules (r2 = 0.94)

1.18

Application In Synthesis of [ 67984-81-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 67984-81-0 ]

[ 67984-81-0 ] Synthesis Path-Downstream   1~27

  • 2
  • [ 100-47-0 ]
  • [ 67984-81-0 ]
  • [ 873-62-1 ]
  • [ 4640-29-3 ]
  • [ 19179-36-3 ]
  • 4
  • [ 67984-81-0 ]
  • (S)-α-methylcysteine hydrochloride [ No CAS ]
  • [ 847355-88-8 ]
  • 5
  • [ 5653-62-3 ]
  • [ 67984-81-0 ]
YieldReaction ConditionsOperation in experiment
With aluminum (III) chloride; triethylamine; In toluene; at 30 - 75℃; for 9.5h; Preparation of 2, 3-dihydroxy benzoic acid form 2, 3-dimethoxy benzoic acid To a stirred solution of 2, 3-dimethoxy benzoic acid (lOOg; 0.549 mol) in dichloromethane (500 mL) and catalytic amount of DMF (~2 mL) at a temperature about 30-35°C, thionyl chloride (130.6g ; 1.102 mol) was added and stirred for a period of two hours. Reaction was monitored by TLC for completion of the starting material (NMT- 5percent).If reaction not completed added thionyl chloride (9.8 g; 0.823 mol). Upon completion of reaction, the reaction mass was quenched in to the -5°C chilled aqueous ammonia (580 mL) solution at a temperature below 15°C under stirring. The reaction mass was stirred at temperature 30-35°C over a period of 30 min. The separated organic fraction was concentrated under atmospheric distillation at below 50°C, charged toluene (100 ml) and co-distilled until the reaction mass moisture content become less than 0.5 percent. The obtained benzamide compound was dissolved in toluene (500 mL) at temperature about 30-35°C.To the reaction mass was added POCl3 (126.3 g; 0.824 mol).The temperature of the reaction mass was raised to 80-85°C and maintained over a period of 1 -2 hours for the completion of the reaction (Progress of the reaction was monitored by HPLC until the benzamide NMT 1.0 percent). If the reaction was not completed, added second lot of POCl3 (lO.lg; 0.06 mol) at 30-35°C. The reaction mass was cooled to a temperature about 30-35°C upon completion of the reaction. The reaction mixture was added to cold water (1000 mL) at 0-5°C.The organic fraction was separated and washed with 8percent sodium bicarbonate solution. The organic fraction was separated and azeotropic distilled at 110-115°C (until moisture content NMT 0.2 percent), after reaching moisture content to normal limit cooled the reaction mass temperature to 40°C and distilled reaction mass volume becomes ~3 volumes under vacuum at a temperature 40-50°C.After distillation cooled the reaction mass temperature to 30-35°C. In another RB flask charged toluene (160 ml), triethyl amine (199.7 g; 1.977 mol) at 30-35°C and stirred for 10 min. charged aluminum chloride (52.7 g 5; 1.977 mol) in five lots with the gap of 10 min between each lot addition (addition of aluminum chloride may raise the temperature to 45-50°C). The reaction mass temperature was raised to about 70-75 °C and added above reaction mass (methoxy compound) for 30 min. maintained the reaction mass at 70-75°C for 8 hr. Progress of the reaction was monitored by HPLC (until the 2,3-dimethoxybenzonitrile content 0.25 percent and 3-methoxy-2-hydroxybenzonitrile content 0.2 percent). If reaction was not completed added second lot of triethyl amine (27.7 g; 0.27 mol) and aluminum chloride (36.6 g; 0.27 mol).Upon completion of the reaction, the reaction mixture was cooled to 30-35°C and quenched with chilled aqueous HC1 (prepared by addition of water (500 ml) and Cone. HC1 (500 ml)) at 15°C. Stirred reaction mass at 25-30°C for about 30 min, filtered the obtained solids and separated aqueous and organic layers. Charged MIBK (320 ml) to the solids and charged above aqueous layer, filtered through celite and separated aqueous and organic layers. To the aqueous layer given MIBK (320+160 ml) extractions. To the combined organic layer given 20percent sodium chloride solution washing, organic layer was azeotropic distilled at 110°C to remove the water (moisture content NMT 0.2 percent).Cooled the reaction mass temperature to 30°C and filtered through 0.45 micron / 1 micron filter. To the filterate charged 1percent EDTA (400 ml), stirred for 30 min and filtered through 10 micron cloth. The organic fraction was separated and distilled off to obtain the residue. The residue was treated with dichloromethane (400 ml) and the solid obtained was filtered and dried under vacuum over 6 hr at 60-65°C to obtain the title compound 2, 3-dihydroxy benzonitrile. (56g, yield 75.4percent) Purity by HPLC 99.81 percent; Impurity A: 0.05percent Impurity B: 0.07 percent
56 g With aluminum (III) chloride; triethylamine; In toluene; at 70 - 75℃; for 8h; Example 1 Preparation of 2,3-dihydroxy benzoic acid form 2,3-dimethoxy benzoic acid [0069] To a stirred solution of 2,3-dimethoxy benzoic acid (100 g; 0.549 mol) in dichloromethane (500 mL) and catalytic amount of DMF (2 mL) at a temperature about 30-35° C., thionyl chloride (130.6 g; 1.102 mol) was added and stirred for a period of two hours. Reaction was monitored by TLC for completion of the starting material (NMT-5percent). If reaction not completed added thionyl chloride (9.8 g; 0.823 mol). Upon completion of reaction, the reaction mass was quenched in to the ?5° C. chilled aqueous ammonia (580 mL) solution at a temperature below 15° C. under stirring. The reaction mass was stirred at temperature 30-35° C. over a period of 30 min. The separated organic fraction was concentrated under atmospheric distillation at below 50° C., charged toluene (100 ml) and co-distilled until the reaction mass moisture content become less than 0.5percent. The obtained benzamide compound was dissolved in toluene (500 mL) at temperature about 30-35° C. To the reaction mass was added POCl3 (126.3 g; 0.824 mol). The temperature of the reaction mass was raised to 80-85° C. and maintained over a period of 1-2 hours for the completion of the reaction (Progress of the reaction was monitored by HPLC until the benzamide NMT 1.0percent). If the reaction was not completed, added second lot of POCl3 (10.1 g; 0.06 mol) at 30-35° C. The reaction mass was cooled to a temperature about 30-35° C. upon completion of the reaction. The reaction mixture was added to cold water (1000 mL) at 0-5° C. The organic fraction was separated and washed with 8percent sodium bicarbonate solution. The organic fraction was separated and azeotropic distilled at 110-115° C. (until moisture content NMT 0.2percent), after reaching moisture content to normal limit cooled the reaction mass temperature to 40° C. and distilled reaction mass volume becomes 3 volumes under vacuum at a temperature 40-50° C. After distillation cooled the reaction mass temperature to 30-35° C. In another RB flask charged toluene (160 ml), triethyl amine (199.7 g; 1.977 mol) at 30-35° C. and stirred for 10 min. charged aluminum chloride (52.7 g×5; 1.977 mol) in five lots with the gap of 10 min between each lot addition (addition of aluminum chloride may raise the temperature to 45-50° C.). The reaction mass temperature was raised to about 70-75° C. and added above reaction mass (methoxy compound) for 30 min. maintained the reaction mass at 70-75° C. for 8 hr. Progress of the reaction was monitored by HPLC (until the 2,3-dimethoxybenzonitrile content 0.25percent and 3-methoxy-2-hydroxybenzonitrile content 0.2percent). If reaction was not completed added second lot of triethyl amine (27.7 g; 0.27 mol) and aluminum chloride (36.6 g; 0.27 mol). Upon completion of the reaction, the reaction mixture was cooled to 30-35° C. and quenched with chilled aqueous HCl (prepared by addition of water (500 ml) and Conc. HCl (500 ml)) at 15° C. Stirred reaction mass at 25-30° C. for about 30 min, filtered the obtained solids and separated aqueous and organic layers. Charged MIBK (320 ml) to the solids and charged above aqueous layer, filtered through celite and separated aqueous and organic layers. To the aqueous layer given MIBK (320+160 ml) extractions. To the combined organic layer given 20percent sodium chloride solution washing, organic layer was azeotropic distilled at 110° C. to remove the water (moisture content NMT 0.2percent). Cooled the reaction mass temperature to 30° C. and filtered through 0.45 micron/1 micron filter. To the filterate charged 1percent EDTA (400 ml), stirred for 30 min and filtered through 10 micron cloth. The organic fraction was separated and distilled off to obtain the residue. The residue was treated with dichloromethane (400 ml) and the solid obtained was filtered and dried under vacuum over 6 hr at 60-65° C. to obtain the title compound 2,3-dihydroxy benzonitrile. (56 g, yield 75.4percent) [0070] Purity by HPLC 99.81percent; [0071] Impurity A: 0.05percent [0072] Impurity B: 0.07percent
  • 6
  • [ 7797-83-3 ]
  • [ 67984-81-0 ]
  • 7
  • [ 138769-96-7 ]
  • (-)-(1S,2R)-3-cyano-3-cyclohexene-1,2-diol [ No CAS ]
  • [ 67984-81-0 ]
  • 8
  • [ 67984-81-0 ]
  • [ 100-97-0 ]
  • [ 28911-18-4 ]
YieldReaction ConditionsOperation in experiment
0.9 g (55%) In water; trifluoroacetic acid; EXAMPLE 95 3,4-Dihydroxy-5-cyanobenzaldehyde A solution containing 1.35 g of <strong>[67984-81-0]2,3-dihydroxybenzonitrile</strong> and 1.4 g of hexamethylene tetramine in 20 ml of trifluoroacetic acid was refluxed for 1.5 h. Water was added and the product was filtered. Yield 0.9 g (55percent), m.p. 211°-215° C.
  • 9
  • [ 67984-81-0 ]
  • [ 62921-74-8 ]
  • [ 1037282-58-8 ]
YieldReaction ConditionsOperation in experiment
70% EXAMPLE 10; [0115] 2-Hydroxy-3-(3,6,9-trioxadecyloxy)benzonitrile (18).; Compound 17 (5.3 g, 39.2 mmol) was added to a suspension of 60percent NaH (3.13 g, 78.2 mmol) in <n="69"/>DMSO (60 mL) using oven-dried glassware. After the reaction mixture was stirred at room temperature for 1 h, 15 (12.49 g, 39.22 mmol) in DMSO (25 mL) was introduced. After 24 h of stirring at room temperature, the reaction mixture was poured with stirring into cold water (100 mL) and was extracted with CHCl3 (3 X 100 mL). The aqueous phase was acidified to pH ~ 1 with 6 N HCl and was extracted with CHCl3 (5 X 60 mL). The latter CHCl3 extracts were concentrated in vacuo. Purification using column chromatography by gravity eluting with 10percent CH3OH/CHC13 gave 7.84 g of 18 (70percent) as an oil: 1H NMR delta 3.40 (s, 3 H), 3.58-3.62 (m, 2 H), 3.65-3.73 (m, 4 H), 3.75-3.78 (m, 2 H), 3.83-3.87 (m, 2 H), 4.14-4.18 (m, 2 H), 6.79-6.85 (m, 1 H), 7.09 (dd, 1 H, J = 7.8, 1.6), 7.15-7.18 (m, 1 H), 8.6 (s, 1 H); 13C NMR delta 57.25, 67.76, 67.85, 68.79, 68.92, 69.06, 70.36, 98.38, 115.44, 116.55, 118.51, 123.13, 145.98, 149.46; HRMS mlz calcd for C14H20NO5, 282.134 (M + H); found, 282.135.
  • 10
  • [ 67-56-1 ]
  • [ 67984-81-0 ]
  • [ 1268613-20-2 ]
  • 11
  • [ 24677-78-9 ]
  • [ 67984-81-0 ]
  • 12
  • [ 67984-81-0 ]
  • [ 739326-10-4 ]
YieldReaction ConditionsOperation in experiment
70% With hydroxylamine hydrochloride; sodium carbonate; In ethanol; water; at 70℃; General procedure: Hydroxylamine hydrochloride (4 mmol) and Na2CO3 (2 mmol) were mixed together in water (3 mL) until the solid dissolves and the gas emission stops. This aqueous solution was added to the corresponding aldehyde or nitrile (1 mmol) in absolute ethanol (0.5 mL).The mixture was heated at 70 °C for 2-24 h. The reaction mixture was then allowed to cool down to room temperature. If the compound precipitated, the solid was filtered off, washed with cold water and dried under vacuum. Otherwise the reaction mixture was extracted with ethyl acetate and dried over Na2SO4. After removal of the solvent the compound was purified by column chromatography (cyclohexane/ethyl acetate) to afford the desired oxime or amidoxime.
  • 13
  • [ 67984-81-0 ]
  • [ 50586-80-6 ]
  • [ 1346427-97-1 ]
YieldReaction ConditionsOperation in experiment
25% Step 12-hydroxy-3-(2-(2-methoxyethoxy)ethoxy)benzonitrileTo a solution of <strong>[67984-81-0]2,3-dihydroxybenzonitrile</strong> (13.5 g, 1 eq.) in DMSO (200 mL) was added NaH (60percent, 8 g, 2eq.) and the resulting solution was stirred for 1 h at 60° C. 2-(2-Methoxyethoxy)ethyl 4-methylbenzenesulfonate (20 g, 0.7eq.) in DMSO (100 mL) was added dropwise at 60° C. and stirring was continued for another 1 h.The reaction was quenched by NH4Cl (sat.), the mixture was extracted with EtOAc (300 mL*3) and the combined organic layers were dried over Na2SO4.The solvent was evaporated and the residue was purified by silicon column (EtOAc/PE=1/1) to give the title compound (6 g, 25percent).LC-MS (ES, m/z): 238 [M+H]+
  • 14
  • [ 67984-81-0 ]
  • [ 1346427-20-0 ]
  • 15
  • [ 67984-81-0 ]
  • [ 1346427-99-3 ]
  • 16
  • [ 67984-81-0 ]
  • [ 1346428-01-0 ]
  • 17
  • [ 67984-81-0 ]
  • [ 50586-80-6 ]
  • [ 1204751-09-6 ]
  • 18
  • [ 67984-81-0 ]
  • [ 62921-76-0 ]
  • [ 1360431-26-0 ]
  • 19
  • [ 67984-81-0 ]
  • [ 62921-74-8 ]
  • [ 1443045-62-2 ]
YieldReaction ConditionsOperation in experiment
A 100 gallon glass lined reactor was charged with 2,3- dihydroxybenzonitrile (4) and dimethyl sulfoxide. A 300 gallon glass lined reactor was charged with potassium tert-butoxide and dimethyl sulfoxide. The <strong>[67984-81-0]2,3-dihydroxybenzonitrile</strong> solution was slowly charged over 1 hour to the potassium tert-butoxide solution maintaining the temperature at <50°C. The reaction mixture was agitated. 2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4- methylbenzenesulfonate (3) was charged over a 1 hour period to the reaction mixture. The reaction mixture was agitated for 2 hours and sampled for reaction completion analysis by HPLC. The reaction was quenched by charging USP water and agitating for 1 hour. The product was isolated first by washing the reaction mixture twice with methyl t-butyl ether. 6N HC1 was charged to the aqueous mixture. The product was then extracted twice with methylene chloride. The organic layers (product layers) were combined and the solvent was exchanged into ethanol by vacuum distillation. A 30percent sodium hydroxide solution was charged to the product dissolved in ethanol. Methyl t-butyl ether was added to help completely precipitate the product. The product was isolated by vacuum filtration. The wet cake was dried for over 15 hours in a tumble drier at 40°C. The reaction yielded sodium 2-cyano-6-(2-(2-(2-methoxyethoxy)ethoxy) ethoxy)phenolate (5).
  • 20
  • [ 1521-39-7 ]
  • [ 67984-81-0 ]
  • 21
  • [ 7169-06-4 ]
  • [ 67984-81-0 ]
  • 22
  • [ 67984-81-0 ]
  • [ 303-38-8 ]
YieldReaction ConditionsOperation in experiment
56 g With hydrogenchloride; water; In toluene; at 15 - 35℃; for 0.5h; Preparation of 2, 3-dihydroxy benzoic acid form 2, 3-dimethoxy benzoic acid To a stirred solution of 2, 3-dimethoxy benzoic acid (lOOg; 0.549 mol) in dichloromethane (500 mL) and catalytic amount of DMF (~2 mL) at a temperature about 30-35°C, thionyl chloride (130.6g ; 1.102 mol) was added and stirred for a period of two hours. Reaction was monitored by TLC for completion of the starting material (NMT- 5percent).If reaction not completed added thionyl chloride (9.8 g; 0.823 mol). Upon completion of reaction, the reaction mass was quenched in to the -5°C chilled aqueous ammonia (580 mL) solution at a temperature below 15°C under stirring. The reaction mass was stirred at temperature 30-35°C over a period of 30 min. The separated organic fraction was concentrated under atmospheric distillation at below 50°C, charged toluene (100 ml) and co-distilled until the reaction mass moisture content become less than 0.5 percent. The obtained benzamide compound was dissolved in toluene (500 mL) at temperature about 30-35°C.To the reaction mass was added POCl3 (126.3 g; 0.824 mol).The temperature of the reaction mass was raised to 80-85°C and maintained over a period of 1 -2 hours for the completion of the reaction (Progress of the reaction was monitored by HPLC until the benzamide NMT 1.0 percent). If the reaction was not completed, added second lot of POCl3 (lO.lg; 0.06 mol) at 30-35°C. The reaction mass was cooled to a temperature about 30-35°C upon completion of the reaction. The reaction mixture was added to cold water (1000 mL) at 0-5°C.The organic fraction was separated and washed with 8percent sodium bicarbonate solution. The organic fraction was separated and azeotropic distilled at 110-115°C (until moisture content NMT 0.2 percent), after reaching moisture content to normal limit cooled the reaction mass temperature to 40°C and distilled reaction mass volume becomes ~3 volumes under vacuum at a temperature 40-50°C.After distillation cooled the reaction mass temperature to 30-35°C. In another RB flask charged toluene (160 ml), triethyl amine (199.7 g; 1.977 mol) at 30-35°C and stirred for 10 min. charged aluminum chloride (52.7 g 5; 1.977 mol) in five lots with the gap of 10 min between each lot addition (addition of aluminum chloride may raise the temperature to 45-50°C). The reaction mass temperature was raised to about 70-75 °C and added above reaction mass (methoxy compound) for 30 min. maintained the reaction mass at 70-75°C for 8 hr. Progress of the reaction was monitored by HPLC (until the 2,3-dimethoxybenzonitrile content 0.25 percent and 3-methoxy-2-hydroxybenzonitrile content 0.2 percent). If reaction was not completed added second lot of triethyl amine (27.7 g; 0.27 mol) and aluminum chloride (36.6 g; 0.27 mol).Upon completion of the reaction, the reaction mixture was cooled to 30-35°C and quenched with chilled aqueous HC1 (prepared by addition of water (500 ml) and Cone. HC1 (500 ml)) at 15°C. Stirred reaction mass at 25-30°C for about 30 min, filtered the obtained solids and separated aqueous and organic layers. Charged MIBK (320 ml) to the solids and charged above aqueous layer, filtered through celite and separated aqueous and organic layers. To the aqueous layer given MIBK (320+160 ml) extractions. To the combined organic layer given 20percent sodium chloride solution washing, organic layer was azeotropic distilled at 110°C to remove the water (moisture content NMT 0.2 percent).Cooled the reaction mass temperature to 30°C and filtered through 0.45 micron / 1 micron filter. To the filterate charged 1percent EDTA (400 ml), stirred for 30 min and filtered through 10 micron cloth. The organic fraction was separated and distilled off to obtain the residue. The residue was treated with dichloromethane (400 ml) and the solid obtained was filtered and dried under vacuum over 6 hr at 60-65°C to obtain the title compound 2, 3-dihydroxy benzonitrile. (56g, yield 75.4percent) Purity by HPLC 99.81 percent; Impurity A: 0.05percent Impurity B: 0.07 percent
  • 23
  • [ 1521-38-6 ]
  • [ 67984-81-0 ]
  • 24
  • [ 19337-60-1 ]
  • [ 2179-92-2 ]
  • [ 67984-81-0 ]
  • 25
  • [ 22536-67-0 ]
  • [ 67984-81-0 ]
  • 2,3-bis[(5-chloro-2-pyrimidinyl)oxy]benzonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
640 mg With potassium carbonate; In N,N-dimethyl-formamide; at 100℃; for 8h;Inert atmosphere; 2,3-Dihydroxybenzonitrile (270 mg, 2 mmol) and 2,5-dichloropyrimidine (655 mg, 4.4 mmol) were combined in N,N-dimethylformamide (6 mL) under a nitrogen atmosphere. Powdered potassium carbonate (1.2 g, 8.8 mmol) was added, and the resulting mixture was heated at 100 °C for 8 h. The reaction mixture was cooled and diluted with water and ethyl acetate. The aqueous layer was separated and extracted with ethyl acetate (3chi). The combined organic layers were washed with brine, dried (MgS04), filtered and concentrated under reduced pressure. The residue was purified by medium pressure liquid chromatography on silica gel, eluted with 0 to 15percent ethyl acetate in hexanes, to yield the title product, a compound of the present invention, as a solid (640 mg). H NMR (400 MHz, CDC13) delta 7.42-7.49 (m, 1H), 7.57 (dd, J=8.31, 1.47 Hz, 1H), 7.65 (dd, J=7.83, 1.96 Hz, 1H), 8.42 (m, 4H).
  • 26
  • [ 67984-81-0 ]
  • [ 945635-15-4 ]
  • 27
  • [ 67984-81-0 ]
  • C18H24NO7S(1-)*Na(1+) [ No CAS ]
 

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