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Chemical Structure| 676256-25-0 Chemical Structure| 676256-25-0

Structure of 676256-25-0

Chemical Structure| 676256-25-0

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Product Details of [ 676256-25-0 ]

CAS No. :676256-25-0
Formula : C10H6ClNO
M.W : 191.61
SMILES Code : O=CC1=CC=C2N=CC=C(Cl)C2=C1
MDL No. :MFCD12024856

Safety of [ 676256-25-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P261-P280-P305+P351+P338-P304+P340-P405

Application In Synthesis of [ 676256-25-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 676256-25-0 ]

[ 676256-25-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 676256-25-0 ]
  • [ 338454-45-8 ]
  • [ 1119899-23-8 ]
YieldReaction ConditionsOperation in experiment
66% With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In water; N,N-dimethyl-formamide; at 150℃; for 0.25h;Microwave irradiation; [0123] To a solution of 2 (1.0 g, 5.2 mmol), <strong>[338454-45-8]5-hydroxymethylthiophene-2-boronic acid</strong> (0.82 g, 5.2 mmol), and Pd(PPh3)4 (0.60 g, 0.078 mmol) in DMF (16 mL) was added Na2CO3 (2.0 M, 4.6 mL). The reaction mixture was heated for 15 min at 150 0C in a Biotage microwave reactor. The resulting mixture was filtered through a pad of silica gel, concentrated and purified by silica gel chromatography (hexanes/EtOAc 100:0 to 0:100 gradient) to afford the title compound as a yellow solid (0.93 g, 66 %).[0124] MS (ES+): m/z 270 (M +H)+
 

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