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Chemical Structure| 675882-71-0 Chemical Structure| 675882-71-0

Structure of 675882-71-0

Chemical Structure| 675882-71-0

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Product Details of [ 675882-71-0 ]

CAS No. :675882-71-0
Formula : C13H18N2O3
M.W : 250.29
SMILES Code : O=C(OC)C1=CC(C)=C(NC(CCC)=O)C(N)=C1
MDL No. :MFCD09033170

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Application In Synthesis of [ 675882-71-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 675882-71-0 ]

[ 675882-71-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 675882-71-0 ]
  • [ 152628-03-0 ]
YieldReaction ConditionsOperation in experiment
EXAMPLE 1; PREPARATION OF 2-n-PROPYL-4-METHYL-BENZIMIDAZOLE -6- CARBOXYLIC ACID (FORMULA III); 11 kg of methyl 4-butyramido-3-methyl-5-nitrobenzoate was dissolved in 165 L of methanol and added to a slurry of water (1 L) and palladium on charcoal (1.02 kg, containing about 50% water by weight). Hydrogen gas was applied to the reaction mass at 3.0-3.5 kg/cm2 pressure at 25-35 C for about 5-6 hours. Reaction completion was confirmed by thin layer chromatography. Filtered the reaction mass through a leaf, online, and micro filter system and washed with 55 L of methanol followed by washing with 50 L of water. Distilled the solvent from the filtrate at a pressure below 600 mm/Hg and a temperature of below 65 C until 15-20 L of reaction mass volume remained. 110 L of water were added to the residue. 3.58 kg of sodium hydroxide in 22 L of water was added to the reaction mass and heated to 95-100C for about 4-5 hours. 44 L of water was added to the reaction mass at 25-3O0C and pH was adjusted to 4.5-5 with a mixture of 36% aqueous hydrochloric acid (8.5 L) and water (8.5 L). Stirred the reaction mass for about 35-45 minutes at 25-300C. Centrifuged the solid and washed with 44 L of EPO <DP n="27"/>water followed by 33 L of acetonitrile. Dried the solid at 60-700C under reduced pressure of about 600-650 mm/Hg for about 4-5 hours to obtain 8.06 kg of the title compound.
 

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