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Chemical Structure| 67478-50-6 Chemical Structure| 67478-50-6

Structure of 67478-50-6

Chemical Structure| 67478-50-6

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Product Details of [ 67478-50-6 ]

CAS No. :67478-50-6
Formula : C23H18N2O
M.W : 338.40
SMILES Code : O=CC1=NC=CN1C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4
MDL No. :MFCD03453110

Safety of [ 67478-50-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 67478-50-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 67478-50-6 ]

[ 67478-50-6 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 96797-15-8 ]
  • [ 68-12-2 ]
  • [ 15469-97-3 ]
  • 4-iodo-2-formyl-1-tritylimidazole [ No CAS ]
  • [ 67478-50-6 ]
  • [ 33016-47-6 ]
  • 2
  • [ 107-31-3 ]
  • [ 15469-97-3 ]
  • [ 67478-50-6 ]
  • 4
  • [ 19012-02-3 ]
  • [ 67478-50-6 ]
  • 1-(1-methyl-1H-indol-3-yl)-3-[1-(triphenylmethyl)-1H-imidazol-2-yl]-2-propen-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium hydroxide; In ethanol; chloroform; water; 1-(1-Methyl-1H-indol-3-yl)-3-[1-(triphenylmethyl)-1H-imidazol-2-yl]-2-propen-1-one A solution of potassium hydroxide (2.5 g) in water (15 ml) was added to a stirred suspension of 3-acetyl-1-methylindole (1.0 g) and 1-(triphenylmethyl)-1H-imidazole-2-carboxaldehyde (2.0 g) in ethanol (40 ml), and the mixture was stirred under nitrogen at 50 for 6 h. The cooled reaction mixture was partitioned between dichloromethane (2*150 ml) and saturated potassium carbonate (150 ml). The combined, dried organic extracts were evaporated in vacuo to leave a solid (ca. 3 g) which was dissolved in chloroform (20 ml) and purified by FCC eluding with ethyl acetate, to give the title compound (0.64 g) t.l.c. (ethyl acetate) Rf 0.14.
  • 5
  • [ 15469-97-3 ]
  • [ 67478-50-6 ]
YieldReaction ConditionsOperation in experiment
75% A cooled (-78°C) yellow solution of 1-(triphenylmethyl)imidazole (25.000 g; 80.542 mmol) in anhydrous THF (750 ml) was treated dropwise (in 55 min.) with a 1.6M solution of butyllithium in hexanes (55.35 ml; 88.560 mmol). After addition, the resulting pink homogeneous solution was further stirred at -78°C, under nitrogen, for 30 min. before a <n="69"/>solution of anhydrous DMF (6.8 ml; 88.186 mmol) in anhydrous THF (40 ml) was added dropwise (in 40 min.). The resulting mixture was additionally stirred at -78°C, under nitrogen, for 1 h before aq. sat. NH4CI (50 ml) was added dropwise. Ether (300 ml) and water (400 ml) were successively added, and this mixture was allowed to warm-up to rt. The yellow organic layer was additionally washed with water (300 ml), dried over anh. MgSO4, filtered, and concentrated to dryness under reduced pressure. The crude was purified by FC (DCM / MeOH = 30 / 1 ) to give the pure product 1 -trityl-1 H-imidazole-2- carbaldehyde as a pale yellow solid which was further dried under HV (20.660 g; 76percent). LC-MS: tR = 1.03 min.; [M+H]+: no ionisation.
 

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