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Batch number can be found on the product's label following the word 'Batch'.
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| CAS No. : | 66548-88-7 |
| Formula : | C11H6ClF3N2 |
| M.W : | 258.63 |
| MDL No. : | MFCD09751568 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
[ 127294-75-1 ]
[ 66548-88-7 ]
| Yield | Reaction Conditions | Operation in experiment |
|---|---|---|
| 25% | Example 38 (General procedure A) 1-[6-(4-Trifluoromethylphenyl)pyridazin-3-yl]piperidin-3-ylamine, hydrochloride: 3-Chloro-6-(4-trifluoromethylphenyl)pyridazine (0.2 g, 0.77 mmol), 3-aminopiperidine dihy- drochloride (0.27 g, 1 .54 mmol) and potassium carbonate (0.53 g, 3.87 mmol) were mixed in acetone (4 ml_) in a 20 ml_ microwave vessel. The reaction mixture was heated in a micro- wave oven for 2 h at 1200C. The reaction mixture was filtered and the precipitate was washed with MeOH. The combined organic phases were evaporated. The crude oil was purified on a silicagel column (0.04-0.063 mesh) using dichloromethane/MeOH (9:1 ) as eluent. This afforded 110 mg of a oil that was dissolved in MeOH and acidified with concentrated HCI (5 ml_). The mixture was evaporated and the residue was dissolved in MeOH (1 ml_) and ether (100 ml_) was added with stirring. The mixture was evaporated to give 76 mg (25 %) of the title compound as a yellow solid. Mp = 97-1350C.1H NMR (400 MHz, CD3OD) delta 1 .74 (m, 2H) 1 .93 (m, 1 H) 2.16 (m, 1 H) 3.35 (m, 3H) 3.44 (m, 1 H) 4.14 (Cj1Cl1 1 H) 4.45 (d,d, 1 H) 4.97 (s, 3H) 7.39 (d, 1 H) 7.75 (d, 2H) 7.78 (s, 2H) 7.95 (s, 1 H) 8.13 (d, 2H).HPLC-MS (Method G): M+1 = 323; tr= 1 .1 17 min. |
