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Chemical Structure| 66438-80-0 Chemical Structure| 66438-80-0

Structure of 66438-80-0

Chemical Structure| 66438-80-0

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Product Details of [ 66438-80-0 ]

CAS No. :66438-80-0
Formula : C10H8BrN
M.W : 222.08
SMILES Code : CC1=C2N=CC(Br)=CC2=CC=C1
MDL No. :MFCD18448354
InChI Key :SHTGZBWYHRHZHT-UHFFFAOYSA-N
Pubchem ID :12465622

Safety of [ 66438-80-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 66438-80-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 66438-80-0 ]

[ 66438-80-0 ] Synthesis Path-Downstream   1~9

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  • [ 1421348-52-8 ]
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  • [ 1421348-90-4 ]
  • [ 1421348-91-5 ]
YieldReaction ConditionsOperation in experiment
11% With copper(l) iodide; cesium acetate; In dimethyl sulfoxide; at 100.0℃; for 24.0h;Inert atmosphere; Sealed tube; To a reaction vial with 4-(1 -Amino-3-methyl-butyryl)-benzoic acid ethyl ester (340 mg, 1.5 mM) was added DMSO (4.88 ml_), <strong>[66438-80-0]3-bromo-8-methylquinoline</strong> (325 mg, 1.46 mM), followed by Cul catalyst (27.8 mg, 0.146 mM) and CsOAc (562 mg, 2.93 mM). The mixture was purged with argon gas and then the tube was sealed. The reaction mixture was heated to 100 for 24 h. The reaction mixture was cooled, diluted with EtOAc (10 ml_), washed with water (3 x 5ml_), dried (Na2S04) and concentrated. The crude material was separated by a 40 g silica gel with 0-50% EtOAc in heptanes to give a yellow color solid product (62 mg, 1 1 %). 1 H NMR (400 MHz, CDCI3) δ ppm 0.95 (d, J=6.25 Hz, 3 H) 1 .00 (d, J=6.25 Hz, 3 H) 1.35 (t, 3 H) 1 .58 - 1 .68 (m, 1 H) 1 .68 - 1.84 (m, 2 H) 2.70 (s, 3 H) 4.33 (q, 2 H) 4.36 - 4.42 (m, 1 H) 4.44 - 4.54 (m, 1 H) 6.74 (d, J=2.93 Hz, 1 H) 7.18 - 7.30 (m, 3 H) 7.43 (d, J=8.39 Hz, 2 H) 8.00 (d, 2 H) 8.48 (d, J=2.93 Hz, 1 H). LC-MS: m/z 377.2 (M+1 ).
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  • [ 930-88-1 ]
  • [ 66438-80-0 ]
  • 3-((3-bromoquinolin-8-yl)methyl)-1-methylpyrrolidine-2,5-dione [ No CAS ]
 

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