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Chemical Structure| 66370-75-0 Chemical Structure| 66370-75-0

Structure of 66370-75-0

Chemical Structure| 66370-75-0

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Product Details of [ 66370-75-0 ]

CAS No. :66370-75-0
Formula : C9H9IO2
M.W : 276.07
SMILES Code : O=C(OC)CC1=CC=CC=C1I
MDL No. :MFCD12025058
InChI Key :YNHWTTUTWBNFGQ-UHFFFAOYSA-N
Pubchem ID :640185

Safety of [ 66370-75-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 66370-75-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 66370-75-0 ]

[ 66370-75-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1025707-93-0 ]
  • [ 66370-75-0 ]
  • [ 1375014-88-2 ]
YieldReaction ConditionsOperation in experiment
36% With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In 1,2-dimethoxyethane; ethanol; at 100℃; for 12h;Inert atmosphere; [0254] To a solution of methyl 2-(2-iodophenyl)acetate (1.3 g, 4.8 mmol) in 20 mL dry DME and EtOH (5 mL) were added <strong>[1025707-93-0]3,4-dihydro-2H-pyran-6-boronic acid pinacol ester</strong> (1.0 g, 4.8 mmol), tetrakis(triphenylphosphine)palladium (0) (277 mg, 0.24 mmol), and sodium carbonate (1.0 g, 9.6 mmol) and the mixture was heated at 100 C for 12 h under N2. The mixture was allowed to cool to room temperature and diluted with ethyl acetate (50 mL) and water (10 mL). The organic layer was separated and the aqueous layer was extracted with ethyl acetate (50 mL X 3). The organic phases were combined, washed with brine and dried over anhydrous Na2SO4. After filtration and concentration, the residue was chromatographed (Combiflash), using 0-20% EtOAc/ petroleum ether as eluent, to give methyl 2-(2-(3,4-dihydro-2H-pyran-6-yl)phenyl)acetate (0.4 g, 36%) as an oil. (ESI 233.1(m+1)+).
 

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