66346-59-6|5,7-Dihydroxy-4-propyl-2H-chromen-2-one| Ambeed

Yield	Reaction Conditions	Operation in experiment
	With sulfuric acid; In ethyl acetate;	EXAMPLE 1 5,7-Dihydroxy-4-propylcoumarin5 (2) Concentrated sulfuric acid (200 mL) was added into a mixture of <strong>[6099-90-7]phloroglucinol dihydrate</strong> (150 g, 0.926 mol) and ethyl butyrylacetate (161 g, 1.02 mol). The resulting mixture was stirred at 90 C. for two hours whereupon it was poured onto ice. The solid product was collected by filtration, and then dissolved in ethyl acetate. The solution was washed with brine and dried over Na2 SO4. After removal of the solvent in vacuo, the residue was triturated with hexane to provide essentially pure compound 2 (203 g) in quantitative yield, mp 233-235 C. (Lit.5 236-238 C.). 1 H-NMR5 (DMSO-d6) delta 0.95 (3H,t,J=6.9 Hz, CH3); 1.63 (2H, apparent sextet, J=7.0 Hz, CH2); 2.89 (2H,t,J=7.5 Hz, CH2); 5.85 (1H, s, H3); 6.22 (1H, d, J=2.0 Hz, H6); 6.31 (1H, d, J=2.0 Hz, H8); 10.27 (1H, s, OH); 10.58 (1H, s, OH); MS (EI); 220(100, M+); 205 (37.9, M-CH3); 192 (65.8, M-C2 H4); 177 (24.8, M-C3 H7); 164 (60.9, M-CHCO2 +1); 163 (59.6 M-CHCO2); IR (KBr): 3210 (vs and broad, OH); 1649 (vs, sh); 1617 (vs, sh); 1554 (s) cm-1; Anal. calcd. for C12 H24 O4: C, 65.45; H, 5.49; Found: C, 65.61; H, 5.44.
	With sulfuric acid; In ethyl acetate;	EXAMPLE 1 5,7-Dihydroxy-4-propylcoumarin5 (2) Concentrated sulfuric acid (200 mL) was added into a mixture of <strong>[6099-90-7]phloroglucinol dihydrate</strong> (150 g, 0.926 mol) and ethyl butyrylacetate (161 g, 1.02 mol). The resulting mixture was stirred at 90 C. for two hours whereupon it was poured onto ice. The solid product was collected by filtration, and then dissolved in ethyl acetate. The solution was washed with brine and dried over Na2 SO4. After removal of the solvent in vacuo, the residue was triturated with hexane to provide essentially pure compound 2 (203 g) in quantitative yield, mp 233-235 C. (Lit.5 236-238 C.). 1 H-NMR5 (DMSO-d6) delta0.95 (3H,t,J=6.9 Hz, CH3); 1.63 (2H, apparent sextet, J=7.0 Hz, CH2); 2.89 (2H,t,J=7.5Hz,CH2); 5.85 (1H, s, H3); 6.22 (1H, d, J=2.0 Hz, H6); 6.31 (1H, d, J=2.0 Hz, H8); 10.27 (1H, s, OH); 10.58 (1H, s, OH); MS (EI); 220(100, M+); 205 (37.9, M-CH3); 192 (65.8, M-C2 H4); 177 (24.8, M-C3 H7); 164 (60.9, M-CHCO2 +1); 163 (59.6 M-CHCO2); IR (KBr): 3210 (vs and broad, OH); 1649 (vs, sh); 1617 (vs, sh); 1554 (s) cm-1; Anal. calcd. for C12 H24 O4: C, 65.45; H, 5.49; Found: C, 65.61; H, 5.44.
	With sulfuric acid; In ethyl acetate;	EXAMPLE 1 5,7-Dihydroxy-4-propylcoumarin5 (2) Concentrated sulfuric acid (200 mL) was added into a mixture of <strong>[6099-90-7]phloroglucinol dihydrate</strong> (150 g, 0.926 mol) and ethyl butyrylacetate (161 g, 1.02 mol). The resulting mixture was stirred at 90C for two hours whereupon it was poured onto ice. The solid product was collected by filtration, and then dissolved in ethyl acetate. The solution was washed with brine and dried over Na2 SO4. After removal of the solvent in vacuo, the residue was triturated with hexane to provide essentially pure compound 2 (203 g) in quantitative yield, mp 233-235 C. (Lit.5 236-238 C.). 1 H-NMR5 (DMSO-d6) delta 0.95 (3H,t,J=6.9 Hz, CH3); 1.63 (2H, apparent hextet, J=7.0 Hz, CH2); 2.89 (2H,t,J=7.5 Hz,CH2); 5.85 (1H, s, H3); 6.22 (1H, d, J=2.0 Hz, H6); 6.31 (1H, d, J=2.0 Hz, H8); 10.27 (1H, s, OH); 10.58 (1H, s, OH); MS (EI); 220(100, M+); 205 (37.9, M--CH3); 192 (65.8, M--C2 H4); 177 (24.8, M--C3 H7); 164 (60.9, M--CHCO2 +1); 163 (59.6 M--CHCO2); IR (KBr): 3210 (vs and broad, OH); 1649 (vs, sh); 1617 (vs, sh); 1554 (s) cm-1); Anal. calcd. for C12 H24 O4: C, 65.45; H, 5.49; Found: C, 65.61; H, 5.44.

	In ethyl acetate;	EXAMPLE 1 5,7-Dihydroxy-4-propylcoumarin55 (2) Concentrated sulfric acid (200 mL) was added into a mixture of <strong>[6099-90-7]phloroglucinol dihydrate</strong> (150 g, 0.926 mol) and ethyl butyrylacetate (161 g, 1.02 mol). The resulting mixture was stirred at 90 C. for two hours whereupon it was poured onto ice. The solid product was collected by filtration, and then dissolved in ethyl acetate. The solution was washed with brine and dried over Na2SO4. After removal of the solvent in vacuo, the residue was triturated with hexane to provide essentially pure compound 2 (203 g) in quantitative yield, mp 233-235 C. (Lit.55 236-238 C.). 1H-NMR55 (DMSO-6) delta0.95 (3H, t, J=6.9 Hz, CH3); 1.63 (2H, apparent sextet, J=7.0 Hz, CH2); 2.89 (2H, t, J=7.5Hz,CH2); 5.85 (1H, s, H3); 6.22 (1H, d, J=2.0 Hz, H6); 6.31 (1H, d, J=2.0 Hz, H8); 10.27 (1H, s, OH); 10.58 (1H, s, OH); MS (EI); 220(100, M+); 205 (37.9, M-CH3); 192 (65.8, M-C2H4); 177 (24.8, M-C3H7); 164 (60.9, M-CHCO2+1); 163 (59.6 M-CHCO2); IR (KBr): 3210 (vs and broad, OH); 1649 (vs, sh); 1617 (vs, sh); 1554 (s) cm-1; Anal. calcd. for C12H24O4: C, 65.45; H, 5.49;.Found: C, 65.61; H, 5.44.
	With sulfuric acid; In ethyl acetate;	EXAMPLE 1 5,7-Dihydroxy4-propylcoumarin5 (2) Concentrated sulfuric acid (200 mL) was added into a mixture of <strong>[6099-90-7]phloroglucinol dihydrate</strong> (150 g, 0.926 mol) and ethyl butyrylacetate (161 g, 1.02 mol). The resulting mixture was stirred at 90 C. for two hours whereupon it was poured onto ice. The solid product was collected by filtration, and then dissolved in ethyl acetate. The solution was washed with brine and dried over Na2SO4. After removal of the solvent in vacuo, the residue was triturated with hexane to provide essentially pure compound 2 (203 g) in quantitative yield, mp 233-235 C. (Lit.5 236-238 C.). 1H-NMR5 (DMSO-d6) delta0.95 (3H, t, J=6.9 Hz, CH3); 1.63 (2H, apparent sextet, J=7.0 Hz, CH2); 2.89 (2H, t, J=7.5Hz, CH2); 5.85 (1H, s, H3); 6.22 (1H, d, J=2.0 Hz, H6); 6.31 (1H, d, J=2.0 Hz, H8); 10.27 (1H, s, OH); 10.58 (1H, s, OH); MS (EI); 220(100, M+); 205 (37.9, M-1055 CH3); 192 (65.8, M-C2H4); 177 (24.8, M-C3H7); 164 (60.9, M-CHCO2+1); 163 (59.6 M-CHCO2); IR (KBr): 3210 (vs and broad, OH); 1649 (vs, sh); 1617 (vs, sh); 1554 (s) cm-1; Anal. calcd. for C12H24O4: C, 65.45; H, 5.49; Found: C, 65.61; H, 5.44.

5,7-Dihydroxy-4-propyl-2H-chromen-2-one

CAS No.: 66346-59-6

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