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Chemical Structure| 6601-37-2 Chemical Structure| 6601-37-2

Structure of 6601-37-2

Chemical Structure| 6601-37-2

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Product Details of [ 6601-37-2 ]

CAS No. :6601-37-2
Formula : C3H9NO2S
M.W : 123.17
SMILES Code : CCS(=O)(NC)=O
MDL No. :MFCD06042345

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Application In Synthesis of [ 6601-37-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 6601-37-2 ]

[ 6601-37-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 19745-07-4 ]
  • [ 6601-37-2 ]
  • [ 1245215-80-8 ]
YieldReaction ConditionsOperation in experiment
25.5% Preparation of N-fdelta-chloroDyrazin^-vD-N-methylethanesulfonamide (SM-9):(SM-9)To a solution of N-methyl-ethanesufonamide (400 mg, 3.25 mmol) in methanol (2.2 ml_) was added potassium hydroxide (85percent, 214 mg, 3.25 mmol). Solvent was removed and the potassium salt was suspended in dimethylsulfoxide (1.0 ml_) and added to a stirred solution of 2,5- dichloropyrazine (484 mg, 3.25 mmol) in dimethylsufoxide (1.0 ml_). The resulting dark colored reaction mixture was stirred at room temp for 45 minutes. The reaction mixture was quenched in ice water and the dark suspension was extracted three times with dichloromethane. The combined organics were washed with brine, dried over sodium sulfate and flash chromatographed eluting with a 0-40percent gradient of ethyl acetate in heptane to afford N-(5-chloropyrazin-2-yl)-N-methyl ethanesulfonamide (SM-9: 195 mg, 25.5percent).1H NMR (400 MHz, CHLOROFORM-d) ppm 1.32 (t, J=7.43 Hz, 3 H), 3.26 (q, J=7.30 Hz, 2 H), 3.42 (s, 3 H), 8.32 (d, J=1.37 Hz, 1 H), 8.56 (d, J=1.17 Hz, 1 H). MS (M+1 ) 236.0.
 

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