65632-62-4|(S)-1-((Benzyloxy)carbonyl)hexahydropyridazine-3-carboxylic acid| Ambeed

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Quality Control of [ 65632-62-4 ] Purity: 95% SDS Specification

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Product Details of [ 65632-62-4 ]

CAS No. :	65632-62-4
Formula :	C₁₃H₁₆N₂O₄
M.W :	264.28
SMILES Code :	O=C([C@@H]1CCCN(C(OCC2=CC=CC=C2)=O)N1)O
MDL No. :	MFCD09751404
InChI Key :	ZYBMAAOZXXKYTG-NSHDSACASA-N
Pubchem ID :	11129166

Safety of [ 65632-62-4 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 65632-62-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 65632-62-4 ]

[ 65632-62-4 ] Synthesis Path-Downstream 1~35

1
[ 65632-62-4 ]
[ 908093-98-1 ]
[ 160885-42-7 ]

References: [1]Tetrahedron Letters,1994,vol. 35,p. 7685 - 7688.

2
[ 67-56-1 ]
[ 65632-62-4 ]
[ 173656-97-8 ]

Yield	Reaction Conditions	Operation in experiment
99%	With thionyl chloride; at 0 - 20℃; for 1h;Heating / reflux;	The hexahydropyridazinic acid (40 g; 0.151 mol) is dissolved in 200 ml of methanol and cooled to 0 C. SOCl2 (36 ml; 0.45 mol) is added dropwise. The solution becomes clear; the temperature is allowed to return very gradually to ambient temperature, and the solution is then refluxed for one hour. The mixture is poured onto a DCM(200 ml)/ice(500 g) /NaHCO3(60 g) mixture. The aqueous phase is extracted with DCM. The organic phase is washed with a saturated NaHCO3 solution and then dried over MgSO4. A colorless oil is obtained (41 g; 99%) and is used as it is.
99%		a) Esterification of the Acid Function; The hexahydropyridazinic acid (40 g; 0.151 mol) is dissolved in 200 ml of methanol and cooled to 0 C. SOCl2 (36 ml; 0.45 mol) is added dropwise. The solution becomes clear; the temperature is allowed to return very gradually to ambient temperature and the solution is then refluxed for one hour. The mixture is poured onto a DCM(200 ml)/ice(500 g)/NaHCO3(60 g) mixture. The aqueous phase is extracted with DCM. The organic phase is washed with a saturated NaHCO3 solution and then dried over MgSO4. A colorless oil (41 g; 99%) is obtained and is used as it is.

References: [1]Patent: US2005/215553,2005,A1 .Location in patent: Page/Page column 7-8.
[2]Patent: US2005/171346,2005,A1 .Location in patent: Page/Page column 9.
[3]Heterocycles,1995,vol. 41,p. 2487 - 2498.

3
[ 176237-47-1 ]
[ 65632-62-4 ]

References: [1]Synthesis,1996,p. 223 - 229.

4
[ 65632-62-4 ]
[ 193814-78-7 ]
[ 193814-80-1 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1997,vol. 7,p. 1757 - 1762.

5
[ 65632-62-4 ]
[ 174260-84-5 ]
(S)-2-[(2R,4S)-2-(2-Biphenyl-4-yl-ethyl)-4-tert-butoxycarbonyl-octanoyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1997,vol. 7,p. 1757 - 1762.

6
[ 501-53-1 ]
(3R)-piperazic acid trifluoroacetic acid salt [ No CAS ]
[ 65632-62-4 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1587 - 1592.
[2]Journal of Organic Chemistry,2004,vol. 69,p. 1734 - 1737.
[3]Chemistry - A European Journal,2015,vol. 21,p. 3031 - 3041.

7
[ 65632-62-4 ]
[ 115-11-7 ]
[ 72064-51-8 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1587 - 1592.

8
[ 7524-50-7 ]
[ 65632-62-4 ]
benzyl 3-((S)-1-methoxy-1-oxo-3-phenylpropan-2-ylcarbamoyl)piperazine-1-carboxylate [ No CAS ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 1734 - 1737.

9
[ 13033-84-6 ]
[ 65632-62-4 ]
(S)-3-((R)-1-Methoxycarbonyl-2-phenyl-ethylcarbamoyl)-tetrahydro-pyridazine-1-carboxylic acid benzyl ester [ No CAS ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 1734 - 1737.

10
[ 65632-62-4 ]
[ 672307-44-7 ]
[ 672307-45-8 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 1734 - 1737.

11
[ 672307-41-4 ]
[ 65632-62-4 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 1734 - 1737.

12
[ 4509-90-4 ]
[ 65632-62-4 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 1734 - 1737.
[2]Journal of Organic Chemistry,2004,vol. 69,p. 1734 - 1737.
[3]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1587 - 1592.

13
[ 156699-37-5 ]
[ 65632-62-4 ]

14
[ 156699-39-7 ]
[ 65632-62-4 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 1734 - 1737.
[2]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1587 - 1592.

15
[ 156699-38-6 ]
[ 65632-62-4 ]

16
[ 65632-62-4 ]
Sch 382583 [ No CAS ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 1734 - 1737.

17
[ 65632-62-4 ]
[ 672307-47-0 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 1734 - 1737.

18
[ 65632-62-4 ]
[ 672307-46-9 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 1734 - 1737.

19
(4S)-3-[[(3S)-hexahydro-3-pyridazinyl]carbonyl]-4-(phenylmethyl)-2-oxazolidinone dihydrochloride [ No CAS ]
[ 65632-62-4 ]

References: [1]Journal of Organic Chemistry,2004,vol. 69,p. 1734 - 1737.

20
[ 65632-62-4 ]
[ 88767-96-8 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1587 - 1592.

21
[ 65632-62-4 ]
[ 88767-18-4 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1587 - 1592.

22
[ 65632-62-4 ]
[ 106860-13-3 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1587 - 1592.

23
[ 65632-62-4 ]
[ 106860-22-4 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1587 - 1592.

24
[ 65632-62-4 ]
[ 106928-72-7 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1587 - 1592.

25
[ 65632-62-4 ]
(S)-3-[((1S,9S)-9-Benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carbonyl)-amino]-4-oxo-butyric acid [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1587 - 1592.

26
[ 65632-62-4 ]
[ 192753-57-4 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1587 - 1592.

27
[ 65632-62-4 ]
[ 192753-53-0 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1587 - 1592.

28
[ 65632-62-4 ]
(S)-2-[(S)-4-Chlorocarbonyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyryl]-hexahydro-pyridazine-3-carboxylic acid tert-butyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1587 - 1592.

29
[ 65632-62-4 ]
[ 192755-43-4 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1587 - 1592.

30
[ 65632-62-4 ]
[ 234752-71-7 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 1587 - 1592.

31
[ 61177-53-5 ]
[ 65632-62-4 ]

References: [1]Synthesis,1996,p. 223 - 229.

32
[ 176237-44-8 ]
[ 65632-62-4 ]

References: [1]Synthesis,1996,p. 223 - 229.

33
[ 176237-43-7 ]
[ 65632-62-4 ]

References: [1]Synthesis,1996,p. 223 - 229.

34
[ 176237-45-9 ]
[ 65632-62-4 ]

References: [1]Synthesis,1996,p. 223 - 229.

35
[ 176237-46-0 ]
[ 65632-62-4 ]

References: [1]Synthesis,1996,p. 223 - 229.

Historical Records

Technical Information

• Acyl Group Substitution • Arndt-Eistert Homologation • Chan-Lam Coupling Reaction • Complex Metal Hydride Reductions • Hunsdiecker-Borodin Reaction • Hydride Reductions • Lawesson's Reagent • Passerini Reaction • Preparation of Amines • Preparation of Carboxylic Acids • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Carboxylic Acids • Schmidt Reaction • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Ugi Reaction

Related Functional Groups of
[ 65632-62-4 ]

Aryls

A461533 [1676-86-4]

(S)-Benzyl (4-(2,5-dioxooxazolidin-4-yl)butyl)carbamate

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A130496 [126401-22-7]

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Similarity: 0.68

Amides

A461533 [1676-86-4]

(S)-Benzyl (4-(2,5-dioxooxazolidin-4-yl)butyl)carbamate

Similarity: 0.72

A212019 [180609-56-7]

Methyl N-Cbz-piperidine-2-carboxylate

Similarity: 0.69

A183829 [28697-11-2]

(S)-1-N-Cbz-Pipecolinic acid

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Similarity: 0.68

Carboxylic Acids

A183829 [28697-11-2]

(S)-1-N-Cbz-Pipecolinic acid

Similarity: 0.68

A205730 [28697-07-6]

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H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 65632-62-4

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